Recombinant Human ARPC2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ARPC2-702H
Product Overview : ARPC2 MS Standard C13 and N15-labeled recombinant protein (NP_005722) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
Source : HEK293
Species : Human
Tag : Myc&DDK
Molecular Mass : 34.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ARPC2 actin related protein 2/3 complex subunit 2 [ Homo sapiens (human) ]
Official Symbol : ARPC2
Synonyms : ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2 (34 kD); actin-related protein 2/3 complex subunit 2; ARC34; p34 Arc; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; PRO2446; p34-Arc; PNAS-139;
Gene ID : 10109
mRNA Refseq : NM_005731
Protein Refseq : NP_005722
MIM : 604224
UniProt ID : O15144

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.


      Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.


        Highly recommended!

        Q&As (6)

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        What cellular processes rely on ARPC2 and the Arp2/3 complex? 11/02/2021

        The Arp2/3 complex, including ARPC2, is essential for various cellular processes. It plays a critical role in cell migration and adhesion, enabling cells to move and change shape. The complex is also involved in endocytosis, phagocytosis, and vesicle trafficking, regulating membrane dynamics. Additionally, ARPC2 and the Arp2/3 complex contribute to cell division, neuronal development, and immune cell function.

        How is the expression of ARPC2 regulated at the molecular level? 11/24/2020

        The expression of ARPC2 can be regulated transcriptionally through the binding of specific transcription factors to the promoter region of the ARPC2 gene. Additionally, post-transcriptional mechanisms like microRNAs or RNA-binding proteins can also affect the stability or translation efficiency of ARPC2 mRNA. Furthermore, epigenetic modifications, such as DNA methylation or histone acetylation, can play a role in regulating ARPC2 gene expression.

        Are there any known diseases or disorders associated with ARPC2 mutations? 10/14/2020

        Mutations in the ARPC2 gene have been linked to a rare genetic disorder called Wiskott-Aldrich syndrome (WAS). WAS is characterized by immune system abnormalities, eczema, and a higher risk of developing certain types of cancer. Although mutations in the ARPC2 gene are relatively rare in WAS, they can disrupt the normal function of the Arp2/3 complex, leading to actin cytoskeleton defects.

        Is the expression of the ARPC2 gene regulated during development? 10/07/2020

        Yes, the expression of the ARPC2 gene can be regulated during development. Transcription factors specific to certain developmental stages or tissues can bind to the regulatory regions of the gene and control its expression. Additionally, epigenetic modifications may also influence the expression patterns of ARPC2 during development.

        Are there any known inhibitors or activators of ARPC2? 11/26/2017

        Currently, there are no specific inhibitors or activators targeting ARPC2 directly. However, various compounds and drugs that target the Arp2/3 complex or actin cytoskeleton dynamics in general can indirectly impact the function of ARPC2. These include small molecule inhibitors of actin polymerization and drugs that modulate actin-binding proteins involved in regulating ARPC2 activity.

        Are there any interacting proteins or complexes that interact with ARPC2? 06/13/2017

        ARPC2 interacts with several other proteins and complexes involved in actin cytoskeleton regulation. It forms a stable complex with other subunits (ARPC1-5) to constitute the Arp2/3 complex. This complex interacts with nucleation promoting factors (NPFs) such as WASP and WAVE, which facilitate actin filament branching. Furthermore, ARPC2 can also interact with actin-binding proteins and signaling molecules, leading to cytoskeletal rearrangements and cellular responses.

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