ARPC5
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Official Full Name
actin related protein 2/3 complex, subunit 5, 16kDa
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ARPC5 involved in several pathways and played different roles in them. We selected most pathways ARPC5 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Axon guidance | EPHA2;SRGAP3;SPNA1;TRPC5;EFNA1;DUSP7;DNM2;PAK4;CNTN1 |
B Cell Receptor Signaling Pathway | PLEKHA2;RAC3;PPP3CC;BLK;BTK;FOS;INPP5D;ARPC4;MAP4K1 |
Bacterial invasion of epithelial cells | CD2AP;VCL;SEPT11;HCLS1;CBL;PIK3R5;WASF1;RHOA;PIK3R3 |
CDC42 signaling events | ARPC3;BAIAP2;IQGAP3;ARPC1B;CTNNA1;TNK2;CDC42BPA;EPS8;ACTR2 |
Developmental Biology | MED26;CDK8;HELZ2;FRS2A;FRS2B;DUSP6;DLG3;RHOGA;CARM1 |
EPH-Ephrin signaling | DNM1;MYL12A;CLTB;MYL9;ARPC4;EFNA1A;ARPC1B;MYL12B;EPHB4B |
EPHB-mediated forward signaling | EPHB4B;ARPC1A;EFNB2;EFNB3B;ARPC1B;ACTR3;EFNB3;EPHB3A;KALRNB |
Endocytosis | ERBB4;TGFBR1A;WIPF2B;EGFRA;ARPC5B;VPS25;ASAP2A;CYTH1;ARPC3 |
ARPC5 has several biochemical functions, for example, contributes_to actin filament binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC5 itself. We selected most functions ARPC5 had, and list some proteins which have the same functions with ARPC5. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
contributes_to actin filament binding | ACTR3;ARPC2;ACTR2;MYH10;ARPC5;MYH9;ARPC3;ARPC4;ARPC1B |
protein binding | HAPLN2;AEBP2;MCM2;NEK2;TDRD7;HOXB6;PARN;COMMD10;GLRA1 |
structural constituent of cytoskeleton | TPM1;CYLC2;TUBA8L3;NEFH;ACTA1;NGS;F-KER;SYNM;TUBB2B |
ARPC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC5.
EIF3H; ACTR3B; EGFR; ZWINT; Cdk1; Itga5; MYH11; CAPZA2; ARRB1; Actb; CDC42; ACTR2; GRB2; DBN1; RNASEH2B; Myh10; Flnb; SYNPO; Lima1; ANLN
- Q&As
- Reviews
Q&As (9)
Ask a questionStudies in animal models have demonstrated that ARPC5 is essential for embryonic development. Knockout or depletion of ARPC5 leads to severe developmental defects, including abnormalities in neurodevelopment, highlighting its importance during embryogenesis.
Yes, alterations in ARPC5 expression or function can significantly impact cell migration. Since ARPC5 is a crucial component of the ARP2/3 complex involved in actin nucleation and branching, dysregulation of ARPC5 can lead to impaired cell migration and changes in cell morphology.
Currently, there is limited information available on the post-translational modifications of ARPC5. Further research is needed to investigate if ARPC5 undergoes any modifications like phosphorylation or ubiquitination, which could potentially regulate its activity and interactions.
To date, no specific diseases have been directly linked to ARPC5 mutations. However, given its involvement in actin dynamics and cellular processes, dysregulation of ARPC5 could potentially contribute to various diseases, including those involving developmental defects or abnormalities in cell migration.
Current research on ARPC5 is focused on understanding its molecular mechanisms within the ARP2/3 complex, investigating its roles in cellular processes like cell migration and adhesion, and exploring its potential implications in disease progression. Additionally, there is ongoing research to identify specific regulators or modulators of ARPC5 activity for therapeutic purposes.
ARPC5 interacts with other subunits of the ARP2/3 complex, including ARPC2 and ARPC4, forming a stable protein complex. This interaction is necessary for the proper functioning of the ARP2/3 complex in actin nucleation.
Yes, ARPC5 can play a role in cellular adhesion through its involvement in actin dynamics. The ARP2/3 complex, including ARPC5, contributes to the formation of structures like lamellipodia and focal adhesions, which are essential for cell adhesion to the extracellular matrix.
Apart from its interaction with the ARP2/3 complex, ARPC5 can also interact with other actin-binding proteins, such as cortactin and N-WASP (Neuronal Wiskott-Aldrich Syndrome Protein). These interactions contribute to the regulation of actin dynamics and various cellular processes.
Yes, emerging evidence suggests that ARPC5 may play a role in cancer progression and metastasis. The dysregulation of actin dynamics, in which ARPC5 is involved, can affect cellular processes such as invasion and migration, which are crucial for cancer metastasis.
Customer Reviews (3)
Write a reviewIts stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.
the ARPC5 protein has proven to be invaluable in protein electron microscopy structure analysis.
The ARPC5 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
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