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ARPC5

  • Official Full Name

    actin related protein 2/3 complex, subunit 5, 16kDa

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC5-4975H Recombinant Human Actin Related Protein 2/3 Complex, Subunit 5, 16kDa, His-tagged Human His
Human ARPC5-3539H Recombinant Human ARPC5, His-tagged Human His
Human ARPC5-9886H Recombinant Human ARPC5, His-tagged E.coli His 1-154a.a.
Human ARPC5-696H Recombinant Human actin related protein 2/3 complex, subunit 5, 16kDa, His-tagged E.coli His
Human ARPC5-849H Recombinant Human ARPC5 protein, GST-tagged Wheat Germ GST
Human ARPC5-8683HCL Recombinant Human ARPC5 293 Cell Lysate HEK293 N/A
Human ARPC5-4772H Recombinant Human ARPC5 protein, GST-tagged E.coli GST 1-154aa
Human ARPC5-2106H Recombinant Human ARPC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARPC5-1099HF Recombinant Full Length Human ARPC5 Protein, GST-tagged In Vitro Cell Free System GST 154 amino acids
Human ARPC5-151H Recombinant Human ARPC5 Protein, His-tagged Human Cells His
Mouse ARPC5-1970M Recombinant Mouse ARPC5 Protein Mammalian Cell His
Mouse ARPC5-750M Recombinant Mouse ARPC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Arpc5-1727M Recombinant Mouse Arpc5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ARPC5-750M-B Recombinant Mouse ARPC5 Protein Pre-coupled Magnetic Beads HEK293
Rat ARPC5-799R Recombinant Rat ARPC5 Protein Mammalian Cell His
Rat ARPC5-455R Recombinant Rat ARPC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARPC5-455R-B Recombinant Rat ARPC5 Protein Pre-coupled Magnetic Beads HEK293
Chicken ARPC5-3203C Recombinant Chicken ARPC5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARPC5 involved in several pathways and played different roles in them. We selected most pathways ARPC5 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEPHA2;SRGAP3;SPNA1;TRPC5;EFNA1;DUSP7;DNM2;PAK4;CNTN1
B Cell Receptor Signaling PathwayPLEKHA2;RAC3;PPP3CC;BLK;BTK;FOS;INPP5D;ARPC4;MAP4K1
Bacterial invasion of epithelial cellsCD2AP;VCL;SEPT11;HCLS1;CBL;PIK3R5;WASF1;RHOA;PIK3R3
CDC42 signaling eventsARPC3;BAIAP2;IQGAP3;ARPC1B;CTNNA1;TNK2;CDC42BPA;EPS8;ACTR2
Developmental BiologyMED26;CDK8;HELZ2;FRS2A;FRS2B;DUSP6;DLG3;RHOGA;CARM1
EPH-Ephrin signalingDNM1;MYL12A;CLTB;MYL9;ARPC4;EFNA1A;ARPC1B;MYL12B;EPHB4B
EPHB-mediated forward signalingEPHB4B;ARPC1A;EFNB2;EFNB3B;ARPC1B;ACTR3;EFNB3;EPHB3A;KALRNB
EndocytosisERBB4;TGFBR1A;WIPF2B;EGFRA;ARPC5B;VPS25;ASAP2A;CYTH1;ARPC3

ARPC5 has several biochemical functions, for example, contributes_to actin filament binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC5 itself. We selected most functions ARPC5 had, and list some proteins which have the same functions with ARPC5. You can find most of the proteins on our site.

Function Related Protein
contributes_to actin filament bindingACTR3;ARPC2;ACTR2;MYH10;ARPC5;MYH9;ARPC3;ARPC4;ARPC1B
protein bindingHAPLN2;AEBP2;MCM2;NEK2;TDRD7;HOXB6;PARN;COMMD10;GLRA1
structural constituent of cytoskeletonTPM1;CYLC2;TUBA8L3;NEFH;ACTA1;NGS;F-KER;SYNM;TUBB2B

ARPC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC5.

EIF3H; ACTR3B; EGFR; ZWINT; Cdk1; Itga5; MYH11; CAPZA2; ARRB1; Actb; CDC42; ACTR2; GRB2; DBN1; RNASEH2B; Myh10; Flnb; SYNPO; Lima1; ANLN

  • Q&As
  • Reviews

Q&As (9)

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Is ARPC5 essential for embryonic development? 11/28/2022

Studies in animal models have demonstrated that ARPC5 is essential for embryonic development. Knockout or depletion of ARPC5 leads to severe developmental defects, including abnormalities in neurodevelopment, highlighting its importance during embryogenesis.

Can alterations in ARPC5 expression or function affect cell migration? 06/19/2022

Yes, alterations in ARPC5 expression or function can significantly impact cell migration. Since ARPC5 is a crucial component of the ARP2/3 complex involved in actin nucleation and branching, dysregulation of ARPC5 can lead to impaired cell migration and changes in cell morphology.

Are there any known post-translational modifications of ARPC5? 09/09/2021

Currently, there is limited information available on the post-translational modifications of ARPC5. Further research is needed to investigate if ARPC5 undergoes any modifications like phosphorylation or ubiquitination, which could potentially regulate its activity and interactions.

Are there any known diseases associated with ARPC5 mutations? 12/22/2020

To date, no specific diseases have been directly linked to ARPC5 mutations. However, given its involvement in actin dynamics and cellular processes, dysregulation of ARPC5 could potentially contribute to various diseases, including those involving developmental defects or abnormalities in cell migration.

What are some current areas of active research regarding ARPC5? 06/26/2020

Current research on ARPC5 is focused on understanding its molecular mechanisms within the ARP2/3 complex, investigating its roles in cellular processes like cell migration and adhesion, and exploring its potential implications in disease progression. Additionally, there is ongoing research to identify specific regulators or modulators of ARPC5 activity for therapeutic purposes.

How does ARPC5 interact with the ARP2/3 complex? 05/29/2020

ARPC5 interacts with other subunits of the ARP2/3 complex, including ARPC2 and ARPC4, forming a stable protein complex. This interaction is necessary for the proper functioning of the ARP2/3 complex in actin nucleation.

Can ARPC5 play a role in cellular adhesion? 06/12/2019

Yes, ARPC5 can play a role in cellular adhesion through its involvement in actin dynamics. The ARP2/3 complex, including ARPC5, contributes to the formation of structures like lamellipodia and focal adhesions, which are essential for cell adhesion to the extracellular matrix.

Are there any known binding partners of ARPC5 besides the ARP2/3 complex? 12/13/2017

Apart from its interaction with the ARP2/3 complex, ARPC5 can also interact with other actin-binding proteins, such as cortactin and N-WASP (Neuronal Wiskott-Aldrich Syndrome Protein). These interactions contribute to the regulation of actin dynamics and various cellular processes.

Does ARPC5 have any role in cancer progression or metastasis? 08/22/2016

Yes, emerging evidence suggests that ARPC5 may play a role in cancer progression and metastasis. The dysregulation of actin dynamics, in which ARPC5 is involved, can affect cellular processes such as invasion and migration, which are crucial for cancer metastasis.

Customer Reviews (3)

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Reviews
06/26/2022

    Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

    08/19/2020

      the ARPC5 protein has proven to be invaluable in protein electron microscopy structure analysis.

      03/20/2020

        The ARPC5 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

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