ARRB2

  • Official Full Name

    arrestin, beta 2

  • Overview

    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

  • Synonyms

    ARRB2;arrestin, beta 2;ARB2;ARR2;BARR2;beta-arrestin-2;arrestin 3;arrestin beta-2

Recombinant Proteins

  • Human
  • Rat
  • Bovine
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • In Vitro Cell Free System
  • HEK293
  • GST
  • Non
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARRB2-9893H Recombinant Human ARRB2, GST-tagged E.coli Human GST 162-408a.a.
ARRB2-26621TH Recombinant Human ARRB2 Wheat Germ Human Non 110 amino acids
ARRb2-3639H Recombinant Human ARRb2 protein(Asp262~Cys430), His-GST-tagged E.coli Human GST&His Asp262~Cys430
ARRB2-803R Recombinant Rat ARRB2 Protein Mammalian Cells Rat His
ARRB2-855H Recombinant Human ARRB2 protein, GST-tagged Wheat Germ Human GST
ARRB2-130HCL Recombinant Human ARRB2 cell lysate Human Non
ARRB2-0340H Recombinant Human ARRB2 Protein (Met1-Cys409), C-His-tagged E.coli Human His Met1-Cys409
ARRB2-0341H Recombinant Human ARRB2 Protein, Tag Free E.coli Human Non
ARRB2-1247HF Recombinant Full Length Human ARRB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 409 amino acids
ARRB2-459R Recombinant Rat ARRB2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ARRB2-459R-B Recombinant Rat ARRB2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ARRB2-631B Recombinant Bovine ARRB2 protein, His-GST-tagged E.coli Bovine GST&His 240-420aa

    Involved Pathway

    ARRB2 involved in several pathways and played different roles in them. We selected most pathways ARRB2 participated on our site, such as MAPK signaling pathway,Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF21,RAC1A,FGF18,FGF1A,CACNA1H,FGFR4,PAK2A,FASLG,AKT1,NF1
    Chemokine signaling pathway Ccl21a,SRC,GNAI2,BCAR1,Ccl27a,XCL2,Adcy4,NFKBIA,GNG8,CCR10
    Dopaminergic synapse PPP2R5B,MAPK8,CAMK2B,GNG7,CLOCK,DRD4,PPP2R1A,CREB3,GNG11,SLC18A1
    Endocytosis CAPZB,ACAP2,RAB11FIP5,ARPC5A,EHD2,CHMP6B,SPG21,ASAP1A,RLN1,WIPF2
    Olfactory transduction PDE1B,OR13A1,CALM3,OLFR998,OLFR477,OR2A42,OR8B8,OR7C1,OLFR491,OLFR181

    Protein Function

    ARRB2 has several biochemical functions, for example, 14-3-3 protein binding,D1 dopamine receptor binding,G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARRB2 itself. We selected most functions ARRB2 had, and list some proteins which have the same functions with ARRB2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding CPSF1,PARP4,H2AFX,TSPAN14,HAND1,DIS3L,DYM,PDE4DIP,CFTR,HMGA1-RS1
    low-density lipoprotein particle receptor binding LRP2,AP2M1,MESDC2,LRPAP1,CCDC167,SLC9A3R2,SACS,PCSK9,SNX17,SYT1
    D1 dopamine receptor binding DRD3,GNAS,DLG4,AGTR1A,ATP1A3,CAV2,PTPN11
    mitogen-activated protein kinase binding ATF7,GTF2I,MAPKAPK5,CDK5RAP3,MAPKAPK2A,MICALCL,PTPRJ,MAPKAPK2,MAPKAPK2B,DUSP2
    protein complex scaffold SLC9A3R1,ITSN1,SMARCD1,ISCU,WWC3,HOMER1,AKAP1,AXIN1,SEPT2,MAGI1
    ubiquitin protein ligase binding NDUFS2,ARRB1,CLU,H2-AB1,UBE2C,UBOX5,TRAF3,LC3,MAGEC2,ERBB2
    protein complex binding DISC1,RNF40,MLC1,RBX1,TRADD,RRAS,Casp3,AP2A2,NR0B2,VDAC1
    receptor binding CSK,DDO,AMACR,EFNA1,NRG2,PKD2,NRG2A,CD2,SLC9A3R1,PTK2
    protein binding RING1,EIF2A,ASCL4,FANCB,FLAD1,CAMTA2,ANK2,LGALS6,KREMEN1,ANKRD17

    Interacting Protein

    ARRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARRB2.

    MDM2;MAPK9;ARRB1;PPM1B

    ARRB2 Related Signal Pathway

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