ART4
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Official Full Name
ADP-ribosyltransferase 4 (Dombrock blood group)
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Overview
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. -
Synonyms
ART4; ADP-ribosyltransferase 4 (Dombrock blood group); ADP ribosyltransferase 4 , ADP ribosyltransferase 4 (DO blood group) , DO, Dombrock blood group; ecto-ADP-ribosyltransferase 4; CD297; DOK1; ADP ribosyltransferase 4 (DO blood group); ADP ribosyltransferase 4 (Dombrock blood group); ADP ribosyltransferase 4; ART 4; CD297 antigen; DO; Dombrock blood group carrier molecule; Ecto ADP ribosyltransferase 4; Mono ADP ribosyltransferase 4; Mono(ADP ribosyl)transferase 4; NAD(P)(+) arginine ADP ribosyltransferase 4; mono-ADP-ribosyltransferase 4; mono(ADP-ribosyl)transferase 4; ADP-ribosyltransferase 4 (DO blood group); NAD(P)(+)--arginine ADP-ribosyltransferase 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- GST
- hFc
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ART4-870H | Recombinant Human ART4 protein, GST-tagged | Wheat Germ | GST |
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| Human | ART4-301319H | Recombinant Human ART4 protein, GST-tagged | E.coli | GST | Met1-Gly60 |
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| Human | ART4-101H | Recombinant Human ART4 Protein, His-tagged | E.coli | His |
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| Human | ART4-3374H | Recombinant Human ART4 protein, His-tagged | E.coli | His | 47-285 aa | |
| Human | ART4-1019HF | Recombinant Full Length Human ART4 Protein, GST-tagged | In Vitro Cell Free System | GST | 314 amino acids |
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| Human | ART4-4528H | Recombinant Human ART4 Protein (Met1-Val314), C-His tagged | Mammalian cells | C-His | Met1-Val314 |
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| Mouse | ART4-960M | Recombinant Mouse ART4 Protein, His-tagged | HEK293 | His |
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| Mouse | Art4-7420M | Recombinant Mouse Art4 protein, hFc-tagged | HEK293 | hFc | Met1-Lys263 |
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| Mouse | ART4-1541MCL | Recombinant Mouse ART4 cell lysate | Human Cell | N/A |
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| Rat | Art4-8800R | Recombinant Rat Art4, His tagged | Human Cell | His |
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| Rat | Art4-716R | Recombinant Rat Art4 protein, His & T7-tagged | E.coli | His/T7 | Tyr51~Cys275 (Accession# F1MA10) |
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| Rat | ART4-1194RCL | Recombinant Rat ART4 cell lysate | Human Cell | N/A |
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| Cynomolgus Monkey | ART4-140C | Recombinant Cynomolgus ART4, Fc tagged | Human Cell | Fc |
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| Cynomolgus Monkey | ART4-141C | Recombinant Cynomolgus ART4, His tagged | Human Cell | Fc |
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| Cynomolgus Monkey | ART4-925CCL | Recombinant Cynomolgus ART4 cell lysate | Human Cell | N/A |
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| Chicken | ART4-3890C | Recombinant Chicken ART4 | Mammalian Cell | His |
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- ART4 Related Articles
ART4 involved in several pathways and played different roles in them. We selected most pathways ART4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ART4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ART4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ART4 itself. We selected most functions ART4 had, and list some proteins which have the same functions with ART4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
ART4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ART4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ART4.
- Q&As
- Reviews
Q&As (6)
Ask a questionBeyond its enzymatic role in ADP-ribosylation, ART4 does not have well-characterized non-enzymatic functions or specific protein interactions.
ART4 transfers ADP-ribose from NAD+ to specific target proteins, modifying their structure and function.
Mutations in the ART4 gene are not commonly associated with diseases or disorders in humans.
ART4 itself is not targeted therapeutically. However, understanding its role in blood group antigen regulation may have implications in blood transfusion medicine and compatibility testing.
ART4 ADP-ribosylates specific glycoproteins on the surface of red blood cells, such as the P1 and P2 antigens.
ART4 activity depends on the availability of NAD+ as a substrate, and it may also be regulated by cellular signaling pathways related to red blood cell function.
Customer Reviews (3)
Write a reviewWith its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.
In addition to its outstanding quality, the Art4 Protein exhibits exceptional stability during storage and usage.
Their team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.
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