|Official Full Name||ATPase, Ca++ transporting, plasma membrane 3|
|Background||The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.|
|Synonyms||ATP2B3; ATPase, Ca++ transporting, plasma membrane 3; plasma membrane calcium-transporting ATPase 3; plasma membrane calcium transporting ATPase 3; PMCA3; plasma membrane calcium pump; plasma membrane calcium ATPase; PMCA3a|
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ATP2B3 involved in several pathways and played different roles in them. We selected most pathways ATP2B3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
ATP2B3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B3 itself. We selected most functions ATP2B3 had, and list some proteins which have the same functions with ATP2B3. You can find most of the proteins on our site.
ATP2B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B3.