ATP6AP1

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ATP6AP1

Official Full Name ATPase, H+ transporting, lysosomal accessory protein 1
Background This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.
Synonyms ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1; ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; V-type proton ATPase subunit S1; 16A; Ac45; CF2; ORF; VATPS1; XAP 3; XAP3; ATP6IP1; ATP6S1; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1; ATPase H+ transporting lysosomal accessory protein 1; ATPase H+ transporting lysosomal interacting protein 1; H ATPase subunit; MGC129781; Protein XAP 3; Protein XAP3; V ATPase Ac45 subunit; V ATPase S1 accessory protein; V ATPase subunit S1; V type proton ATPase subunit S1; Vacuolar ATP synthase subunit S1; protein XAP-3; H-ATPase subunit; OTTHUMP00000032115; OTTHUMP00000196463; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting pro; XAP-3
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6AP1-8592HCL Recombinant Human ATP6AP1 293 Cell Lysate HEK293 N/A
    Human ATP6AP1-992H Recombinant Human ATP6AP1 protein, GST-tagged Wheat Germ GST
    Rat ATP6AP1-883R Recombinant Rat ATP6AP1 Protein Mammalian Cell His
    Chicken ATP6AP1-4576C Recombinant Chicken ATP6AP1 Mammalian Cell His

    ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP6V1E2; ATP5IB; COX6B2; ATP6V0D2; NDUFA2; ATP6V1C1A; NDUFS4; ATP6V0CB; ATP5G3B; NDUFV2
    Metabolic pathways MBOAT2B; MTM1; CMAS; EXT1C; ALOX8; GCLM; DCTPP1; CELL; UGT1A7; SPTLC3
    Lysosome CTSLA; CTPS1B; SLC17A5; ATP6V0B; NEU1; NAGLU; CTSH; LAPTM4A; AP1S2; DNASE2
    Phagosome HLA-DMB; C3; CTSLA; CALR; ITGB2L; ATP6V0D1; ITGAV; TLR4; ATP6V0A4; BLB2
    Vibrio cholerae infection TJP2; KDELR2; ACTG1; ATP6V0D1; ERO1L; ATP6V1H; ATP6AP1; SEC61G; ATP6V1E1; ACTB
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1A; JAM3; CXCL1; RAC1; MAPK9; CXCR1; ATP6V1G1; PAK1; ATP6V1H; ATP6V0D2
    Tuberculosis IFNA2; FCGR2A; MRC2; CLEC7A; ITGAX; ATP6V0A1; IFNA16; SPHK2; BAD; CALM2
    Hepatitis B TBK1; MAP2K1; MAP2K4; IRF7; FASLG; HBXIP; CCNE1; CXCL8; CREB3L2; RB1
    Rheumatoid arthritis IL6; FLT1; TGFB1; ATP6V1F; TEK; ATP6V1A; HLA-DRB4; ATP6V0C; ITGB2L; ATP6V1D

    ATP6AP1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding QARS; PSMC3; CSNK2A2; MAPK12A; MKNK1; DCAKD; ITGB1BP3; ACTB; GATB; APAF1
    Rab GTPase binding RIMS1; RPH3A; RAB11FIP5; RAB11FIP4; EVI5; ULK1; GDI1; USP6NL; SYTL4; STX4A
    proton-transporting ATP synthase activity, rotational mechanism ATP5E; ATP5O; ATP5A1; ATP5C1; ATP5B; ATP6AP1B; ATP6V0C; ATP6AP1
    proton-transporting ATPase activity, rotational mechanism ATP6V0B; ATP6V1E1B; ATP6V0E2; ATP6V0A1; ATP6V0A1B; ATP6V0A2; ATP6V0C; ATP6V0A1A; ATP6V0A2B; ATP6AP1B
    transporter activity Slc4a2; AP2S1; RLBP1B; TIMM9; SLC2A15A; FABP6; STEAP1; RBP2A; SLC22A1; SEC22A

    ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.

    NR1I2; ANG; ERBB2; HBA1; Kcnk1; ATP6AP2; cona_canen; Bmpr1a; RAB7A; K3; DBN1; Chmp4b; MYEF2; Spast; Tmed2; GOLT1B

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