|Official Full Name||ATPase, H+ transporting, lysosomal accessory protein 1|
|Background||This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.|
|Synonyms||ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1; ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; V-type proton ATPase subunit S1; 16A; Ac45; CF2; ORF; VATPS1; XAP 3; XAP3; ATP6IP1; ATP6S1; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1; ATPase H+ transporting lysosomal accessory protein 1; ATPase H+ transporting lysosomal interacting protein 1; H ATPase subunit; MGC129781; Protein XAP 3; Protein XAP3; V ATPase Ac45 subunit; V ATPase S1 accessory protein; V ATPase subunit S1; V type proton ATPase subunit S1; Vacuolar ATP synthase subunit S1; protein XAP-3; H-ATPase subunit; OTTHUMP00000032115; OTTHUMP00000196463; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting pro; XAP-3|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Oxidative phosphorylation||ATP6V1E2; ATP5IB; COX6B2; ATP6V0D2; NDUFA2; ATP6V1C1A; NDUFS4; ATP6V0CB; ATP5G3B; NDUFV2|
|Metabolic pathways||MBOAT2B; MTM1; CMAS; EXT1C; ALOX8; GCLM; DCTPP1; CELL; UGT1A7; SPTLC3|
|Lysosome||CTSLA; CTPS1B; SLC17A5; ATP6V0B; NEU1; NAGLU; CTSH; LAPTM4A; AP1S2; DNASE2|
|Phagosome||HLA-DMB; C3; CTSLA; CALR; ITGB2L; ATP6V0D1; ITGAV; TLR4; ATP6V0A4; BLB2|
|Vibrio cholerae infection||TJP2; KDELR2; ACTG1; ATP6V0D1; ERO1L; ATP6V1H; ATP6AP1; SEC61G; ATP6V1E1; ACTB|
|Epithelial cell signaling in Helicobacter pylori infection||ATP6V1A; JAM3; CXCL1; RAC1; MAPK9; CXCR1; ATP6V1G1; PAK1; ATP6V1H; ATP6V0D2|
|Tuberculosis||IFNA2; FCGR2A; MRC2; CLEC7A; ITGAX; ATP6V0A1; IFNA16; SPHK2; BAD; CALM2|
|Hepatitis B||TBK1; MAP2K1; MAP2K4; IRF7; FASLG; HBXIP; CCNE1; CXCL8; CREB3L2; RB1|
|Rheumatoid arthritis||IL6; FLT1; TGFB1; ATP6V1F; TEK; ATP6V1A; HLA-DRB4; ATP6V0C; ITGB2L; ATP6V1D|
ATP6AP1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.
|ATP binding||QARS; PSMC3; CSNK2A2; MAPK12A; MKNK1; DCAKD; ITGB1BP3; ACTB; GATB; APAF1|
|Rab GTPase binding||RIMS1; RPH3A; RAB11FIP5; RAB11FIP4; EVI5; ULK1; GDI1; USP6NL; SYTL4; STX4A|
|proton-transporting ATP synthase activity, rotational mechanism||ATP5E; ATP5O; ATP5A1; ATP5C1; ATP5B; ATP6AP1B; ATP6V0C; ATP6AP1|
|proton-transporting ATPase activity, rotational mechanism||ATP6V0B; ATP6V1E1B; ATP6V0E2; ATP6V0A1; ATP6V0A1B; ATP6V0A2; ATP6V0C; ATP6V0A1A; ATP6V0A2B; ATP6AP1B|
|transporter activity||Slc4a2; AP2S1; RLBP1B; TIMM9; SLC2A15A; FABP6; STEAP1; RBP2A; SLC22A1; SEC22A|
ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.
NR1I2; ANG; ERBB2; HBA1; Kcnk1; ATP6AP2; cona_canen; Bmpr1a; RAB7A; K3; DBN1; Chmp4b; MYEF2; Spast; Tmed2; GOLT1B