|Official Full Name||ataxin 2|
|Background||The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.|
|Synonyms||ATXN2; ataxin 2; SCA2, spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) , TNRC13; ataxin-2; ATX2; trinucleotide repeat containing 13; Olivopontocerebellar ataxia 2, autosomal dominant; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat containing gene 13 protein; OTTHUMP00000164680; OTTHUMP00000164681; OTTHUMP00000241635; OTTHUMP00000241637; OTTHUMP00000241638; trinucleotide repeat-containing gene 13 protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATXN2 involved in several pathways and played different roles in them. We selected most pathways ATXN2 participated on our site, such as Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Parkinsons Disease Pathway||UBE2J2; PARK7; SYT11; LRRK2; ATXN2|
ATXN2 has several biochemical functions, for example, RNA binding, epidermal growth factor receptor binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN2 itself. We selected most functions ATXN2 had, and list some proteins which have the same functions with ATXN2. You can find most of the proteins on our site.
|RNA binding||RPL5; RPF1; CLUHA; IFIT12; SMN1; RPS25; RBM14; FBL; SRSF1A; TROVE2|
|epidermal growth factor receptor binding||CBLC; ERBB4; AGR2; SNX4; VAV2; PLSCR1; SHC1; SOCS5; HBEGFA; HBEGF|
|poly(A) RNA binding||STAU1; MRPS14; SRP72; RBM7; LUC7L2; C14orf21; TDRD3; DDX46; TWF2; FAM120A|
|protein C-terminus binding||IFT52; FBLN1; TOP2A; ARL6IP5; MAP2K1; PICK1; FOXN3; PLEKHB1; SHANK2; TCF4|
|protein binding||PAF1; FAM195B; TBP; GORASP1; SLC7A1; FGFR1OP; NUDT4; EIF3L; SPG20; RAB9A|
ATXN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN2.
SH3GL2; PABPC1; SH3GL3