bcl2l11
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  • Official Full Name
  • BCL2-like 11 (apoptosis facilitator)
  • Background
  • Bim (bcl-2-interacting mediator of cell death) is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in regulating the intrinsic mitochondrial apoptotic pathway by inducing cytochrome c release, which in turn, activates caspase-9 and then caspase-3. Bim also plays a critical role in central and peripheral deletion of T lymphocytes and in controlling B cell homeostasis and activation. BimEL, the long isoform of Bim, is a ~28 kDa protein that is predominantly expressed in T and B cells and is activated by ERK1/2 pathway. The activation of BimEL by ERK1/2 promotes its phosphorylation on serine 65 (serine 69 in human), targeting it for degradation via the proteasome.
  • Synonyms
  • BCL2L11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl2-L-11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death; Bim; Bod; 1500006F24Rik
Cat.#:BCL2L11-133HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L11, His tagged
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Cat.#:BCL2L11-150HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2L11 Protein, GST-tagged
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Cat.#:BCL2L11-151HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2L11 Protein, GST-tagged
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Cat.#:BCL2L11-1525HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human BCL2L11 protein, His-tagged
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Cat.#:BCL2L11-26430THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2L11 protein, GST-tagged
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Cat.#:BCL2L11-572HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2L11 Protein, His-tagged
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Cat.#:BCL2L11-6967HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Like 11 (apoptosis facilitator), His-tagged
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Cat.#:BCL2L11-2344MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BCL2L11 Protein
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Cat.#:BCL2L11-960RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCL2L11 Protein
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Cat.#:BCL2L11-7198ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BCL2L11
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Cat.#:BCL2L11-1578HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Like 11 (Apoptosis Facilitator)
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Cat.#:BCL2L11-60HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BCL2L11 lysate
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Involved Pathway

BCL2L11 involved in several pathways and played different roles in them. We selected most pathways BCL2L11 participated on our site, such as Activation of BH3-only proteins, Activation of BIM and translocation to mitochondria, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of BH3-only proteins
DYNLL2; YWHAQ; BCL2L11; E2F1; AKT3; CDK5RAP2
Activation of BIM and translocation to mitochondria
BCL2L11
Apoptosis
PIK3CB; MAP3K14; PRKACG; PPP3CC; CAPN1A; NGF; DIABLO; CASP6L1; DCC; DSG3
Apoptosis Modulation and Signaling
BLK; HN1; SEPT4; DAXX; CRADD; CASP2; BOK; BAG3; HRK; CAPNS1
B Cell Receptor Signaling Pathway
MAPK4; PIK3R2; GRB2; PRKCB; VAV3; FOS; FCGR2B; CD19; PPP3R2; ARPC4
BDNF signaling pathway
EIF4E; EIF2S1; CDH2; DOK5; EGR2; GNB2L1; MAP3K2; LINGO1; CSNK2A1P; IGF2BP1
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BCL2L11
Cell death signalling via NRAGE, NRIF and NADE
FGD2; NET1; ARHGEF18A; ARHGEF16; AKAP13; ECT2; AATF; BCL2L11; ARHGAP4; PLEKHG2

Protein Function

BCL2L11 has several biochemical functions, for example, contributes_to microtubule binding, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L11 itself. We selected most functions BCL2L11 had, and list some proteins which have the same functions with BCL2L11. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to microtubule binding
Related Protein BCL2L11
Function microtubule binding
Related Protein DPYSL2; KIF12; PRNP; MACF1; KIF14; MAP205; KIF3C; NDEL1A; TUBGCP5; KIF3A
Function protein binding
Related Protein RAB11A; PRCC; COX4I1; CSF3R; RUSC1-AS1; DNAJA4; DNAJC19; NUDT1; TLE3; CST1

Interacting Protein

BCL2L11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L11 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L11.
MCL1; BCL2L1

BCL2L11 Related Gene Family

BCL2 Gene Family