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BCL2L11

  • Official Full Name

    BCL2-like 11 (apoptosis facilitator)

  • Overview

    Bim (bcl-2-interacting mediator of cell death) is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in regulating the intrinsic mitochondrial apoptotic pathway by inducing cytochrome c release, which in turn, activates caspase-9 and then caspase-3. Bim also plays a critical role in central and peripheral deletion of T lymphocytes and in controlling B cell homeostasis and activation. BimEL, the long isoform of Bim, is a ~28 kDa protein that is predominantly expressed in T and B cells and is activated by ERK1/2 pathway. The activation of BimEL by ERK1/2 promotes its phosphorylation on serine 65 (serine 69 in human), targeting it for degradation via the proteasome.
  • Synonyms

    BCL2L11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl2-L-11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death; Bim; Bod; 1500006F24Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCL2L11-572H Active Recombinant Human BCL2L11 Protein, His-tagged E.coli His Ala2-Arg120
Human BCL2L11-133H Recombinant Human BCL2L11 protein(Ala2-Arg120), His-tagged E. coli N-His Ala2-Arg120
Human BCL2L11-150H Recombinant Human BCL2L11 Protein, GST-tagged Wheat Germ GST
Human BCL2L11-1578H Recombinant Human BCL2-Like 11 (Apoptosis Facilitator) E.coli N/A
Human BCL2L11-151H Recombinant Human BCL2L11 Protein, GST-tagged Wheat Germ GST
Human BCL2L11-6967H Recombinant Human BCL2-Like 11 (apoptosis facilitator), His-tagged E.coli His 1-138aa
Human BCL2L11-1525H Recombinant Human BCL2L11 protein, His-tagged Yeast His 1-198 aa
Human BCL2L11-26430TH Recombinant Human BCL2L11 protein, GST-tagged Wheat Germ GST
Human BCL2L11-60HCL Recombinant Human BCL2L11 lysate HEK293 N/A
Human BCL2L11-2582H Recombinant Human BCL2L11 protein, His-SUMO-tagged E.coli His-SUMO 1-198aa
Human BCL2L11-1629HF Recombinant Full Length Human BCL2L11 Protein, GST-tagged In Vitro Cell Free System GST 109 amino acids
Mouse BCL2L11-2344M Recombinant Mouse BCL2L11 Protein Mammalian Cell His
Mouse BCL2L11-991M Recombinant Mouse BCL2L11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BCL2L11-991M-B Recombinant Mouse BCL2L11 Protein Pre-coupled Magnetic Beads HEK293
Rat BCL2L11-960R Recombinant Rat BCL2L11 Protein Mammalian Cell His
Rat BCL2L11-618R Recombinant Rat BCL2L11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BCL2L11-618R-B Recombinant Rat BCL2L11 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BCL2L11-7198Z Recombinant Zebrafish BCL2L11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCL2L11 Related Gene Family
  • BCL2L11 Related Research Area

BCL2L11 involved in several pathways and played different roles in them. We selected most pathways BCL2L11 participated on our site, such as Activation of BH3-only proteins, Activation of BIM and translocation to mitochondria, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of BH3-only proteinsAKT3;E2F1;YWHAQ;BCL2L11;DYNLL2;CDK5RAP2
Activation of BIM and translocation to mitochondria
ApoptosisDFFB;PRKAR1AB;DBNLA;LMNB1;PIK3CB;DFFA;BCL2A;HELLS;APAF1
Apoptosis Modulation and SignalingCAPNS1;CDKN2A;BCL2L10;BAG3;CRADD;CASP2;BOK;DAXX;BIK
B Cell Receptor Signaling PathwayIGHM;VAV2;MAPK1;PILRB;CRKL;PRKCB;RAC2;HDAC5;RAC1
BDNF signaling pathwaySIRPA;SYN1;EIF4EBP1;CDKL5;CSNK2A1;YBX1;DPYSL2;EGR1;JAK2
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cell death signalling via NRAGE, NRIF and NADETIAM2;NET1;KALRNB;ITSN1;ARHGEF18;CASP2;ARHGAP4;MCF2L;ABR

BCL2L11 has several biochemical functions, for example, contributes_to microtubule binding, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L11 itself. We selected most functions BCL2L11 had, and list some proteins which have the same functions with BCL2L11. You can find most of the proteins on our site.

Function Related Protein
contributes_to microtubule binding
microtubule bindingCENPE;MACF1;KIF3A;CASC1;FGF13;ZNF207;MAST2;ZFP207;MAPRE1A
protein bindingADAM12;NETO2;TXNDC11;FLVCR1;DNM1;PRPF8;INSR;C11orf54;C1orf38

BCL2L11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L11 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L11.

MCL1; BCL2L1

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