brcc3
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  • Official Full Name
  • BRCA1/BRCA2-containing complex, subunit 3
  • Background
  • This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
  • Synonyms
  • BRCC3; BRCA1/BRCA2-containing complex, subunit 3; chromosome X open reading frame 53 , CXorf53; lys-63-specific deubiquitinase BRCC36; BRCC36; C6.1A; BRISC complex subunit BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36
Cat.#:BRCC3-1148HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCC3 Protein, His-SUMO-tagged
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Cat.#:BRCC3-10280HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCC3, His-tagged
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Cat.#:BRCC3-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCC3 protein, His-tagged
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Cat.#:BRCC3-328HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRCC3 Protein, GST-tagged
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Cat.#:BRCC3-2481MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRCC3 Protein
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Cat.#:BRCC3-1011RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BRCC3 Protein
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Cat.#:BRCC3-8412HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRCC3 293 Cell Lysate
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Involved Pathway

BRCC3 involved in several pathways and played different roles in them. We selected most pathways BRCC3 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
SPC25; TUBGCP4; MCM8; CENPJ; NUF2; H3F3D; AHCTF1; RBBP4; MCM6; CCDC99
Cell Cycle Checkpoints
BRE; BARD1; CHEK1; MCM10; FAM175A; HTATIP; RAD9B; HIST4H4; THRSP; CDK2
DNA Double Strand Break Response
SMARCA5; THRSP; KDM4B; BABAM1; EYA3; UIMC1; HTATIP; BRE; RAD50; TP53BP1
DNA Double-Strand Break Repair
PPP4R2A; RAD1; SMARCA5; EME1; RNF4; EYA3; FUZ; RAD9B; TP53BP1; POLD3
DNA Repair
ACTL6A; WRN; FUZ; YY1A; GEN1; PPP4CA; NFRKB; RHNO1; INO80C; COPS3
G2/M Checkpoints
TP53BP1; RAD1; BRCC3; THRSP; BRE; HUS1; BABAM1; FAM175A; RAD9B; RAD9
G2/M DNA damage checkpoint
UIMC1; BARD1; RNF168; FAM175A; BABAM1; BRE; THRSP; TP53BP1; BRCC3
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
GEN1; UIMC1; PPP4R2A; FAM175A; EME2; EME1; RHNO1; KIAA0146; TP53BP1; PPP4R2

Protein Function

BRCC3 has several biochemical functions, for example, enzyme regulator activity, metal ion binding, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCC3 itself. We selected most functions BRCC3 had, and list some proteins which have the same functions with BRCC3. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme regulator activity
Related Protein DPM2; PSMD1; PPP1R7; PSMD3; CPN2; GCLM; EIF2B1; PSMD2; APOC3; DCP1B
Function metal ion binding
Related Protein JMJD1C; ITGA2B; CYP4A10; ZBTB46; HSCB; SLC25A25A; ZNF576; PPM1F; MUL1A; AKAP13
Function metallopeptidase activity
Related Protein NAALADL1; CPD; ACE; AQPEP; PAPPA; PGCP; ADAMTS4; ADAMTS15A; ADAMTSL1; ADAMTS5
Function polyubiquitin binding
Related Protein BRE; THRSP; EPS15; DZIP3; DNAJB2; FAM175A; UBXN1; BRCC3; HDAC6; UBQLN4
Function protein binding
Related Protein PLK3; CD2BP2; PSMC4; AXL; PPP1R3C; CST3; SNCA; GTF2H4; SHOC2; PLK2
Function ubiquitin-specific protease activity
Related Protein USP27X; USP43A; UCHL1; ZRANB1B; USP40; USP48; OTUD5B; ATXN3L; FMNL3; USP1

Interacting Protein

BRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCC3.
BRE; E2F5; NDUFA10; UBC; SHMT2; DDOST; BAG6; ATP5O; MCM2; FAM175B; FAM175A; CAND1; EXOC8; USP7; UIMC1; BABAM1