BRCC3

Home / Products / BRCC3

BRCC3

Official Full Name BRCA1/BRCA2-containing complex, subunit 3
Background This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Synonyms BRCC3; BRCA1/BRCA2-containing complex, subunit 3; chromosome X open reading frame 53 , CXorf53; lys-63-specific deubiquitinase BRCC36; BRCC36; C6.1A; BRISC complex subunit BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BRCC3-10280H Recombinant Human BRCC3, His-tagged E.coli His
    Human BRCC3-105H Recombinant Human BRCC3 protein, His-tagged E.coli His
    Human BRCC3-1148H Recombinant Human BRCC3 Protein, His-SUMO-tagged E.coli His/SUMO
    Human BRCC3-328H Recombinant Human BRCC3 Protein, GST-tagged Wheat Germ GST
    Human BRCC3-8412HCL Recombinant Human BRCC3 293 Cell Lysate HEK293 N/A
    Mouse BRCC3-2481M Recombinant Mouse BRCC3 Protein Mammalian Cell His
    Rat BRCC3-1011R Recombinant Rat BRCC3 Protein Mammalian Cell His

    BRCC3 involved in several pathways and played different roles in them. We selected most pathways BRCC3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle ATM; ITGB3BP; CENPL; CDK7; BLZF1; NCAPD3; PLK1; CEP63; TGFB1; ORC3L
    Cell Cycle Checkpoints BARD1; KAT5; HTATIP; BABAM1; CDKN1B; MCM10; CDK5RAP2; RAD1; DBF4; THRSP
    DNA Double Strand Break Response UIMC1; EYA4; UBE2V2; EYA2; BRCC3; THRSP; BRE; BAZ1B; KDM4A; SMARCA5
    DNA Double-Strand Break Repair EYA2; PPP4R2B; RAD51AP1; BRE; UBE2V2; PARP1; EME2; TDP2B; TOPBP1; CHEK1
    DNA Repair PPP4R2A; EYA4; ALKBH2; WRN; BARD1; RAD9B; RAD9; PAXIP1; EME1; UBE2L6
    G2/M Checkpoints RAD9A; THRSP; RAD1; FAM175A; HUS1; BARD1; RNF168; UIMC1; BRCC3; BABAM1
    G2/M DNA damage checkpoint TP53BP1; BRE; BABAM1; THRSP; BARD1; FAM175A; BRCC3; UIMC1; RNF168
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) UIMC1; RNF168; PPP4CB; FAM175A; RNF4; TIMELESS; RAD9B; KIAA0146; PPP4R2B; TIPIN

    BRCC3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCC3 itself. We selected most functions BRCC3 had, and list some proteins which have the same functions with BRCC3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme regulator activity BRCC3; SEPT2; DCP1B; RGN; DPM2; MTMR9; PSMD2; APOC3; PSMD3; EIF2B1
    metal ion binding CYP11C1; ZNF396; EPX; ZFAND5A; ZFP330; GLIS3; GALNT10; LHX2A; TRIM12A; YBEY
    metallopeptidase activity AFG3L2; COPS5; MMP1A; ANPEP; CLCA5; AMZ2; YME1L1; MMP14B; DPP3; DPEP3
    polyubiquitin binding FAM175A; PSMD4B; UBXN1; VCP; HDAC6; RAD23A; EPS15; TNIP2; UBQLN4; SHARPIN
    protein binding PXMP4; SIRPB1; ZWINT; ZNF426; CDC37L1; CDC42EP4; ATP1A1; DNAJB5; SNAP91; HPX
    ubiquitin-specific protease activity USP9; USP24; USP45; FAM105B; USP40; USP5; OTUD5; OTUD5B; STAMBP; USP16

    BRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCC3.

    BRE; E2F5; NDUFA10; UBC; SHMT2; DDOST; BAG6; ATP5O; MCM2; FAM175B; FAM175A; CAND1; EXOC8; USP7; UIMC1; BABAM1

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved.