capn1
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  • Official Full Name
  • calpain 1, (mu/I) large subunit
  • Background
  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
  • Synonyms
  • CAPN1; calpain 1, (mu/I) large subunit; CANP; muCL; CANP1; CANPL1; muCANP; calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein;
Cat.#:CAPN1-0355HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAPN1 Protein, GST-Tagged
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Cat.#:CAPN1-10699HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPN1, GST-tagged
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Cat.#:CAPN1-164HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CAPN1
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Cat.#:CAPN1-27399THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPN1, His-tagged
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Cat.#:Capn1-2029MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Capn1 protein, His-tagged
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Cat.#:Capn1-2030MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Capn1 protein, His-tagged
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Cat.#:CAPN1-2690MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAPN1 Protein
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Cat.#:CAPN1-1118RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAPN1 Protein
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Cat.#:Capn1-585RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Capn1 protein, His-tagged
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Cat.#:Capn1-586RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Capn1 protein, His-tagged
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Cat.#:CAPN1-624RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CAPN1 Protein, His-tagged
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Cat.#:CAPN1-3464CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAPN1
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Cat.#:CAPN1-27397THTag:N/A
Source (Host):Human erythrocytesSpecies:Human
Product nameNative Human Calpain-1
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Cat.#:CAPN1-8448HTag:N/A
Source (Host):HumanSpecies:Human
Product nameNative Human CAPN1
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Cat.#:CAPN1-186pTag:N/A
Source (Host):Species:Pig
Product nameNative porcine Calpain-1
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Cat.#:CAPN1-65PTag:N/A
Source (Host):Species:Pig
Product nameNative Porcine Active Porcine Calpain 1
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Cat.#:CAPN1-7865HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CAPN1 293 Cell Lysate
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Cat.#:Kit-0151Tag:N/A
Source (Host):Species:
Product nameCAPN1 Inhibitor (Human) Screening Kit
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Involved Pathway

CAPN1 involved in several pathways and played different roles in them. We selected most pathways CAPN1 participated on our site, such as Protein processing in endoplasmic reticulum, Apoptosis, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
TRAM1; RRBP1A; NSFL1C; NGLY1; PDIA3; UBE2D2; BCL2; UBE2G2; HSP90AA1; UBE4B
Apoptosis
BMX; HRK; HIST1H1B; IKBKB; FASLG; NTRK1; GZMC; PIK3R3B; CASP2; AKT2
Alzheimers disease
CALML3; ATP5H; NDUFC2; CAPN2; NDUFS3; MAPK1; LPL; PLCB3; ATF6; GNAQ

Protein Function

CAPN1 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN1 itself. We selected most functions CAPN1 had, and list some proteins which have the same functions with CAPN1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MYLPFB; CALR; PPP3CB; S100U; DLL4; GUCA1E; MELK; PLCD1A; CDH7; C2CD4A
Function calcium-dependent cysteine-type endopeptidase activity
Related Protein CAPN2A; CAPN9; CAPNS1B; CAPN10; CAPN5A; CAPN11; CAPN5; CAPN2; PDCD6; CAPN1
Function cytoskeletal protein binding
Related Protein EPB41L4B; FARP2; EZRB; ANXA2; EPB4.1L4A; NF2A; EPB41L5; PACSIN1A; TOR1AIP1; B4GALT1
Function protein binding
Related Protein FKBP3; RIN3; TINAGL1; SMARCA5; PYGB; NCAPH; S100A8; ZNF165; LCORL; RPLP1

Interacting Protein

CAPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN1.
PTPN1; CAPNS1; STAT3; EZR; RCAN1; TIRAP; F2R; GRIN2B; CLEC4G; ANKRD17; KATNA1; env