CAV1

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CAV1

Official Full Name caveolin 1, caveolae protein, 22kDa
Background The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Synonyms CAV1; caveolin 1, caveolae protein, 22kDa; CAV, caveolin 1, caveolae protein, 22kD; caveolin-1; cell growth-inhibiting protein 32; CGL3; BSCL3; VIP21; MSTP085
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAV1-10749H Recombinant Human CAV1, His-tagged E.coli His
    Human CAV1-215H Recombinant Human CAV1 Protein, His-tagged E.coli His
    Human CAV1-26608TH Recombinant Human CAV1 protein, GST-tagged Wheat Germ GST
    Human CAV1-7822HCL Recombinant Human CAV1 293 Cell Lysate HEK293 N/A
    Mouse Cav1-216M Recombinant Mouse Cav1 Protein, His/GST-tagged E.coli His/GST
    Mouse CAV1-2773M Recombinant Mouse CAV1 Protein Mammalian Cell His
    Rat Cav1-217R Recombinant Rat Cav1 Protein, His-tagged E.coli His
    Chicken CAV1-3752C Recombinant Chicken CAV1 Mammalian Cell His
    Zebrafish CAV1-2964Z Recombinant Zebrafish CAV1 Mammalian Cell His

    CAV1 involved in several pathways and played different roles in them. We selected most pathways CAV1 participated on our site, such as Endocytosis, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis IGF1R; VPS25; ASAP3; RAB35; FAM21A; CLTCB; RAB8A; SPG20A; ZFYVE27; SRC
    Focal adhesion VCLA; ACTN3A; HRASA; ITGB1B.2; COL5A1; SHC1; TNC; PRKCA; RAC3A; MYL9A
    Bacterial invasion of epithelial cells GAB1; ELMO2; DNM1; CTNNA2; CRKL; WASL; SEPT9; CLTB; PIK3R2; CLTA
    Proteoglycans in cancer RAC1; RHOA; MAPK13; FZD3; ACTB; PLCE1; PIK3R2; PIK3CA; PTPN6; FZD7
    Viral myocarditis HLA-DRB3; CASP9; HLA-DPA1; SGCA; HLA-A; HLA-DMB; HLA-DRB1; HLA-B; MYH7; EIF4G3

    CAV1 has several biochemical functions, for example, ATPase binding, MDM2/MDM4 family protein binding, RNA polymerase I transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV1 itself. We selected most functions CAV1 had, and list some proteins which have the same functions with CAV1. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding GRIN2A; ATP6V0A2B; SELS; SNX10; RAB4A; ZNHIT6; Ar; LCK; PIH1D1; ATP6V0A4
    MDM2/MDM4 family protein binding CAV1; CDKN2A; TRP53; PPARA; RFWD3; CDK5RAP3; PSME3
    RNA polymerase I transcription factor binding CAV1; POLR1E
    Rac GTPase binding DOCK7; FLNA; PAK4; PAK7; PAK6; DOCK4; NOXA1; PAK2B; RALBP1; RAB7
    cholesterol binding PROM2; ERLIN2; SYP; OSBPL1A; PMP2; ABCA1; PTCH1; TSPO2; APOF; APOA4
    enzyme binding RAC1; KRT79; CD4; RCOR2; UGT1A6B; P4HB; PPP3CB; LDB2; CAT; HDAC2
    identical protein binding EPOR; C1QL4; SNX16; COL1A2; CTSC; CBLL1; IIGP1; SERPINA1D; APP; SLC2A1
    inward rectifier potassium channel inhibitor activity CAV1
    ion channel binding PACS2; CHERP; PKD1; KCNE2; KCNAB1; SRC; CALM1; ABCC9; CDH5; PHPT1
    nitric-oxide synthase binding SNTA1; CAV1; SLC14A2; CALM2; SLC6A4; CALM3; ATP2B4; CDH2; SCN5A; NOS1AP
    patched binding SETD6; PTCH1; BBS1; DHH; Shh; SMO; CAV1; CCNB1; IHH
    peptidase activator activity CAV1; FBLN1; CLPX; PSME4B; PCOLCE2; PSME4; PINK1; APP; PCOLCE; MMP25
    protein binding MUC2; NXT2; CLK4; PELO; MRPL40; RAB13; TSKS; LBR; MIF; MCC
    protein binding, bridging FSCN1; RBM14; AMFR; WWC1; SPRR1B; CSTA; FBXW7; TRIM6; FSCN2; FLRT2
    protein complex scaffold CAV3; HOMER1; KLHL17; MAGI1; SLC9A3R1; CAV2; PKP2; AKAP6; SLC9A1; WWC1
    protein heterodimerization activity HYPM; BARD1; BRAF; SRI; UGT1A6B; ERBB3; EFHA1; EXT1; NTSR1; EXT2
    protein kinase binding KCNH1; CCNYL1; NEFH; RPS19; ERRFI1; CACNB4; PTPRC; B4GALT1; ARHGEF7; PTPRR
    receptor binding TNFSF13B; UCN2; LGI1; LTA; IL29; SRMS; TMED1; FYNB; F2R; PVRL4
    structural molecule activity KLHL3; KRT7; KRT72-PS; KRTAP11-1; LAMB1; COL18A1; KRT28; EVPL; KRT80; KRT42
    syntaxin binding SCFD1; SYT9; VAMP7; STX10; CPLX2; SNAP29; TXLNA; SYT16; TXLNG; SYT5B

    CAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV1.

    PTPN1; EGFR; TXNRD1; ID1

    Biswas, SK; Brako, L; et al. Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice. EXPERIMENTAL EYE RESEARCH 125:9-19(2014).
    Paunescu, TG; Lu, HAJ; et al. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F1783-F1795(2013).

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