ccl18
Share
  • Official Full Name
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
  • Background
  • This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
  • Synonyms
  • CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18; C-C motif chemokine 18; CC chemokine PARC; OTTHUMP00000163954; CC chemokine ligand 18; chemokine (C-C), dendritic; dendritic cell chemokine 1; small inducible cytokine A18; small-inducible cytokine A18; macrophage inflammatory protein 4; pulmonary and activation-regulated chemokine; alternative macrophage activation-associated CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
Cat.#:CCL18-0616HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL18 Protein, GST-Tagged
+Inquiry
Cat.#:CCL18-2892HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL18 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:CCL18-300HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)
+Inquiry
Cat.#:CCL18-03HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL18 Protein, His-tagged
+Inquiry
Cat.#:CCL18-113HTag:Biotin
Source (Host):Species:Human
Product nameHuman CCL18, Biotin-tagged
+Inquiry
Cat.#:CCL18-200HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL18 protein
+Inquiry
Cat.#:CCL18-244HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CCL18, His-tagged
+Inquiry
Cat.#:CCL18-251HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 18, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:CCL18-252HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 18, MIgG2a Fc-tagged
+Inquiry
Cat.#:CCL18-253HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 18, HIgG1 Fc-tagged
+Inquiry
Cat.#:CCL18-30163THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL18, His-tagged
+Inquiry
Cat.#:CCL18-681RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCL18 Protein, His-tagged
+Inquiry
Cat.#:CCL18-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 18
+Inquiry
Cat.#:CCL18-164HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL18, 22-89 aa, His-tagged
+Inquiry

Involved Pathway

CCL18 involved in several pathways and played different roles in them. We selected most pathways CCL18 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
LTBR; ACKR3B; BMPR2A; EPOR; CCL19B; ACVR2B; IFNGR2; PRL; CXCR6; IFNAR1
Chemokine signaling pathway
PF4V1; PIK3CD; CCR1L1; MAPK1; CCL16; RASGRP2; VAV1; CXCL6; CXCL8; PLCB2

Protein Function

CCL18 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL18 itself. We selected most functions CCL18 had, and list some proteins which have the same functions with CCL18. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL22; CCL17; CCRL2; CCL13; CCL1; CCL34A.4; CCL18; CCL16; CCL20A.3; CCL25B
Function chemokine activity
Related Protein XCL1; CXCL14; Ccl21a; CXCL3; CCL13; CCL38A.4; CCL5; CCL21B; IL8L2; CCL11
Function protein binding
Related Protein IKZF1; RBM41; GTPBP10; SPON1; ZFYVE1; E2F5; IGHM; DOLK; PLIN3; KEAP1

Interacting Protein

CCL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL18.
PITPNM3; TP53; EEF1A1; TLE1; UNC119; CRMP1; C14orf1

CCL18 Related Articles

Xu, Y; Zhang, L; et al. CC Chemokine Ligand 18 and IGF-Binding Protein 6 as Potential Serum Biomarkers for Prostate Cancer. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 233:25-31(2014).
Suga, H; Sugaya, M; et al. The Role of IL-32 in Cutaneous T-Cell Lymphoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1428-1435(2014).

CCL18 Related Gene Family

Chemokines Cytokines