ccr5
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  • Official Full Name
  • chemokine (C-C motif) receptor 5 (gene/pseudogene)
  • Background
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A;
Cat.#:CCR5-0693HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR5 Protein
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Cat.#:CCR5-192HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCR5 Protein, His-tagged
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Cat.#:CCR5-10886HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCR5, GST-tagged
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Cat.#:CCR5-120HTag:GST
Source (Host):Species:Human
Product nameRecombinant Human CCR5, GST-tagged
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Cat.#:CCR5-366HTag:N/A
Source (Host):Species:Human
Product nameHuman CCR5 peptide
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Cat.#:CCR5-3016MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCR5 Protein
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Cat.#:CCR5-1229RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCR5 Protein
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Cat.#:CCR5-708RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCR5 Protein, His-tagged
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Cat.#:CCR5-4659CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCR5
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Cat.#:CCR5-309HCLTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human CCR5 cell lysate
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Cat.#:Kit-1048Tag:
Source (Host):Species:
Product nameNAD+/NADH Colorimetric Assay Kit (384-well)
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Cat.#:Kit-1153Tag:
Source (Host):Species:
Product nameCCR5 CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1154Tag:
Source (Host):Species:
Product nameCCR5 Activated GPCR Internalization Assay Kit
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Cat.#:Kit-1155Tag:
Source (Host):Species:
Product namecAMP CCR5 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-0889Tag:
Source (Host):Species:
Product nameHydroxyl Free Radical Assay Kit
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Involved Pathway

CCR5 involved in several pathways and played different roles in them. We selected most pathways CCR5 participated on our site, such as Binding and entry of HIV virion, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Binding and entry of HIV virion
PPIA; gag; CCR5
Chemokine receptors bind chemokines
ACKR4; CCR7; CXCR6; CCR8; CCL35.2; CXCR7B; AMCF-II; CX3CR1; CCR3; CXCL13
Chemokine signaling pathway
CCL19; SHC2; PLCB1; VAV1; NCF1; HCK; NFKBIB; NRAS; CXCL13; RHOA
Class A/1 (Rhodopsin-like receptors)
CX3CR1; NPFF; PTGDR2; OPN4.1; PRLH; NPB; OPN1LW1; QRFP; FFAR3; PMCH
Cytokine-cytokine receptor interaction
GHRA; Fasl; IL28A; FAS; CXCR4; IL1B; M17; CD70; Il23a; IFNL3
Disease
AP2M1; SYT2; MMAA; AP2A2; NUP50; OPN1MW; ELL; APOBEC3G; NUPL2; AMN
Early Phase of HIV Life Cycle
PSIP1; BANF1; CCR5; gag; PPIA
Endocytosis
SPG20; EEA1; ARRB1; WASLB; MHC1UEA; ERBB4A; HSPA1B; RHOAC; GRK7B; PLD1A

Protein Function

CCR5 has several biochemical functions, for example, C-C chemokine binding, C-C chemokine receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR5 itself. We selected most functions CCR5 had, and list some proteins which have the same functions with CCR5. You can find most of the proteins on our site.
Function
Related Protein
Function C-C chemokine binding
Related Protein ZFP36; CCBP2; CCR1; DARC; CCR5
Function C-C chemokine receptor activity
Related Protein CCR6A; CCR1L1; CCR7; CCBP2; CCR5; CCR3; CCR6; GPR75; CCR9; CCR8
Function actin binding
Related Protein PARVG; MYH1B; ACTN3B; MSRB1A; CNN3; MYO15; MYO1C; ALKBH4; INPPL1A; ENC1
Function chemokine (C-C motif) ligand 5 binding
Related Protein CCR5; CCR1
Function chemokine receptor activity
Related Protein CXCR7B; ACKR4; PRLH2R; ACKR3B; CX3CR1; CMKLR1; CXCR4A; CCRL2; CCR6A; CCR1
Function coreceptor activity
Related Protein ZP2; CXCR7; CD86; RGMA; ACKR3B; CCR8; IGSF1; LRP5; RAMP2; CD8B
Function phosphatidylinositol phospholipase C activity
Related Protein PLD4; PLCL2; PLCD1A; PLCB2; PLCG2; PLCD3; CCKBR; CASR; CCR1; PLCD4
Function protein binding
Related Protein MLH1; PDIA6; RFPL3; CAPN2; JMJD6; NRF1; ZNF69; ADH1A; NSFL1C; CDK18
Function virus receptor activity
Related Protein TNFRSF4; PVRL2; PVR; F11R; HSPA1B; ITGB3; ITGA2; CLEC4G; CLEC4M; PVRL1

Interacting Protein

CCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR5.
CD4; PRAF2; CCL5; CXCR4; ARL6IP5; CCL4; MYH9; CREB3; ETV5; CTBP2; IL24

CCR5 Related Articles

Gardner, MR; Kattenhorn, LM; et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. NATURE 519:87-U173(2015).
Yi, HA; Diaz-Rohrer, B; et al. The Membrane Proximal External Regions of gp41 from HIV-1 Strains HXB2 and JRFL Have Different Sensitivities to Alanine Mutation. BIOCHEMISTRY 54:1681-1693(2015).

CCR5 Related Gene Family

Chemokines Cytokines