CCR5 Protein, chemokine (C-C motif) receptor 5 (gene/pseudogene)

CCR5

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CCR5

Official Full Name chemokine (C-C motif) receptor 5 (gene/pseudogene)
Background This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-0889 Hydroxyl Free Radical Assay Kit N/A
    Human CCR5-0693H Recombinant Human CCR5 Protein Wheat Germ N/A
    Human CCR5-10886H Recombinant Human CCR5, GST-tagged E.coli GST
    Human CCR5-120H Recombinant Human CCR5, GST-tagged Wheat Germ GST
    Human CCR5-192H Recombinant Human CCR5 Protein, His-tagged E.coli His
    Human CCR5-309HCL Recombinant Human CCR5 cell lysate HEK293T Flag
    Human CCR5-366H Human CCR5 peptide N/A
    Mouse CCR5-3016M Recombinant Mouse CCR5 Protein Mammalian Cell His
    Rat CCR5-1229R Recombinant Rat CCR5 Protein Mammalian Cell His
    Rhesus Macaque CCR5-708R Recombinant Rhesus monkey CCR5 Protein, His-tagged Mammalian Cell His
    Chicken CCR5-4659C Recombinant Chicken CCR5 Mammalian Cell His
    Kit-1048 NAD+/NADH Colorimetric Assay Kit (384-well) N/A
    Kit-1153 CCR5 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1154 CCR5 Activated GPCR Internalization Assay Kit N/A
    Kit-1155 cAMP CCR5 CHO-K1 GPCR Assay Kit N/A

    CCR5 involved in several pathways and played different roles in them. We selected most pathways CCR5 participated on our site, such as Binding and entry of HIV virion, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Binding and entry of HIV virion CCR5; gag; PPIA
    Chemokine receptors bind chemokines CCR6; CCR5; CCRL2; AMCF-II; CXCR7B; CCR3; CCL27; CXCR6; CCR7; CCL35.2
    Chemokine signaling pathway CXCL9; GNGT1; Ccl12; CCR1L1; LOC100033925; CCR5; CXCL10; ARRB2; Ccl21a; GM1987
    Class A/1 (Rhodopsin-like receptors) AMCF-II; LPAR5A; NMB; LPAR2B; XK; PENK; GPR31; ADRa1A; CCR8; DRD1
    Cytokine-cytokine receptor interaction TNFRSF13B; Ccl21c; CRFB16; IL6R; IFNA4; IFNW1; CCL1; KITA; GM1987; IFNA1
    Disease TNKS; RCC1; CTDP1; PSTPIP2; CCDC167; AP1S1; CHMP4B; GPC6; PPIA; CTBP1
    Early Phase of HIV Life Cycle gag; CCR5; PSIP1; PPIA; BANF1
    Endocytosis DNM1B; ASAP2; STAMBP; PIP5K1A; SH3GLB2B; IL2RB; ERBB3; ADRB3; CXCR4A; RAB35

    CCR5 has several biochemical functions, for example, C-C chemokine binding, C-C chemokine receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR5 itself. We selected most functions CCR5 had, and list some proteins which have the same functions with CCR5. You can find most of the proteins on our site.

    Function Related Protein
    C-C chemokine binding ZFP36; CCR5; CCR1; DARC; CCBP2
    C-C chemokine receptor activity CCR8; CCBP2; CCR9; CCR1; CCR5; CCR6A; GPR75; CCR1L1; CCR10; CCR7
    actin binding DNASE1; FSCN2B; EPB41L3B; PLEC; SPATA32; KLHL1; YWHAH; PLECA; MYH8; MYH4
    chemokine (C-C motif) ligand 5 binding CCR1; CCR5
    chemokine receptor activity CXCR7B; RGRB; CXCR4B; ACKR4; CCR8; CCR1L1; CXCR3; CXCR3.1; CCR12A; CXCR3.2
    coreceptor activity TMIGD2; CXCR4; CCR8; CD80; CD8A; CXCR7B; ACVR2A; RAMP3; TGFBR3; HFE2
    phosphatidylinositol phospholipase C activity PLCH2; BDKRB2; EDNRA; PLCD1B; CCL5; CCR1; PLCB2; PLCL1; CHRM1; PLCD1A
    protein binding H2-KE2; BAI3; ITGAL; TMEM93; F11; SLC26A6; HIST1H4B; CREB1; C14orf93; PPP3R1
    virus receptor activity CXCR4; SIVA1; CLDN1; MOG; TNFRSF14; TYRO3; IDE; HSPA1A; F11R; SLAMF1

    CCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR5.

    CD4; PRAF2; CCL5; CXCR4; ARL6IP5; CCL4; MYH9; CREB3; ETV5; CTBP2; IL24

    Gardner, MR; Kattenhorn, LM; et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. NATURE 519:87-U173(2015).
    Yi, HA; Diaz-Rohrer, B; et al. The Membrane Proximal External Regions of gp41 from HIV-1 Strains HXB2 and JRFL Have Different Sensitivities to Alanine Mutation. BIOCHEMISTRY 54:1681-1693(2015).

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