CCR5
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Official Full Name
chemokine (C-C motif) receptor 5 (gene/pseudogene)
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Overview
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Alouatta seniculus (Red howler monkey)
- Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey)
- Bos taurus (Bovine)
- Callithrix humeralifera (Tassel-eared marmoset)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
- Cercocebus galeritus (Tana river mangabey)
- Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey)
- Cercopithecus cephus (Moustached monkey)
- Cercopithecus lhoesti (L'Hoest's monkey)
- Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon)
- Cercopithecus solatus (Sun-tailed monkey)
- Chicken
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus)
- Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
- Chlorocebus tantalus (Tantalus monkey) (Cercopithecus tantalus)
- Colobus polykomos (Western black-and-white colobus monkey)
- Erythrocebus patas (Red guenon) (Cercopithecus patas)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Homo sapiens (Human)
- Human
- Hylobates moloch (Silvery gibbon)
- Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus)
- Macaca arctoides (Stump-tailed macaque)
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Macaca mulatta (Rhesus macaque)
- Macaca nemestrina (Pig-tailed macaque)
- Mandrillus leucophaeus (Drill) (Papio leucophaeus)
- Mandrillus sphinx (Mandrill) (Papio sphinx)
- Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)
- Mouse
- Mus musculus (Mouse)
- Nasalis larvatus (Proboscis monkey)
- Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
- Oryctolagus cuniculus (Rabbit)
- Pan paniscus (Pygmy chimpanzee) (Bonobo)
- Pan troglodytes (Chimpanzee)
- Papio anubis (Olive baboon)
- Papio hamadryas (Hamadryas baboon)
- Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Pongo pygmaeus (Bornean orangutan)
- Pygathrix nemaeus (Red-shanked douc langur)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus)
- Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
- Saimiri sciureus (Common squirrel monkey)
- Semnopithecus entellus (Hanuman langur) (Presbytis entellus)
- Symphalangus syndactylus (Siamang) (Hylobates syndactylus)
- Theropithecus gelada (Gelada baboon)
- Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi)
- Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii)
- Trachypithecus phayrei (Phayre's leaf monkey)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- His
- GST
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CCR5-582H | Active Recombinant Human CCR5 Full Length Transmembrane protein(Nanodisc) | HEK293 | N/A | ||
Human | CCR5-366H | Human CCR5 peptide | N/A | |||
Human | CCR5-120H | Recombinant Human CCR5, GST-tagged | Wheat Germ | GST | ||
Human | CCR5-10886H | Recombinant Human CCR5, GST-tagged | E.coli | GST | 257-352a.a. | |
Human | CCR5-0693H | Recombinant Human CCR5 Protein | Wheat Germ | N/A | ||
Human | CCR5-309HCL | Recombinant Human CCR5 cell lysate | HEK293T | Flag | ||
Human | CCR5-644H | Recombinant Human CCR5 Protein, His-tagged | E.coli | N-His | Glu302-Leu352 | |
Human | CCR5-192H | Recombinant Human CCR5 Protein, His-tagged | E.coli | His | ||
Human | CCR5-681H | Recombinant Human CCR5 protein, Flag & His-tagged | HEK293 | Flag/His | Asp 2 - Arg 223 & Glu 227 - Arg 319 | |
Human | CCR5-2356H | Recombinant Human CCR5 Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 1-352aa | |
Human | CCR5-1075HFL | Recombinant Human CCR5 protein, His&Flag-tagged | HEK293 | His&Flag | 1-352 aa | |
Human | CCR5-0621H | Active Recombinant Human CCR5 Full Length Transmembrane protein(VLPs) | HEK293 | N/A | Met 1 - Leu 352 | |
Human | CCR5-3019HF | Recombinant Full Length Human CCR5 Protein | In Vitro Cell Free System | 526 amino acids | ||
Human | CCR5-0881H | Recombinant Human CCR5 Protein (Glu302-Leu352), N-GST tagged | E.coli | N-GST | Glu302-Leu352 | |
Mouse | CCR5-3016M | Recombinant Mouse CCR5 Protein | Mammalian Cell | His | ||
Mouse | CCR5-1423M | Recombinant Mouse CCR5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Ccr5-5363M | Recombinant Mouse Ccr5 protein, His-tagged | Yeast | His | 263-354aa | |
Mouse | CCR5-1423M-B | Recombinant Mouse CCR5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CCR5-1229R | Recombinant Rat CCR5 Protein | Mammalian Cell | His | ||
Rat | CCR5-887R-B | Recombinant Rat CCR5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CCR5-887R | Recombinant Rat CCR5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Alouatta seniculus (Red howler monkey) | RFL35533AF | Recombinant Full Length Alouatta Seniculus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey) | RFL10433AF | Recombinant Full Length Ateles Geoffroyi C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Bos taurus (Bovine) | RFL21302BF | Recombinant Full Length Bovine C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Callithrix humeralifera (Tassel-eared marmoset) | RFL24548CF | Recombinant Full Length Callithrix Humeralifera C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL13344CF | Recombinant Full Length Dog C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) | RFL31667CF | Recombinant Full Length Cercocebus Atys C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercocebus galeritus (Tana river mangabey) | RFL27689CF | Recombinant Full Length Cercocebus Galeritus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey) | RFL33428CF | Recombinant Full Length Cercopithecus Ascanius C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercopithecus cephus (Moustached monkey) | RFL15218CF | Recombinant Full Length Cercopithecus Cephus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercopithecus lhoesti (L'Hoest's monkey) | RFL23095CF | Recombinant Full Length Cercopithecus Lhoesti C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon) | RFL34443CF | Recombinant Full Length Cercopithecus Nictitans C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Cercopithecus solatus (Sun-tailed monkey) | RFL15423CF | Recombinant Full Length Cercopithecus Solatus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | RFL8947CF | Recombinant Full Length Chlorocebus Aethiops C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) | RFL33429CF | Recombinant Full Length Cercopithecus Pygerythrus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) | RFL26666CF | Recombinant Full Length Cercopithecus Sabaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Chlorocebus tantalus (Tantalus monkey) (Cercopithecus tantalus) | RFL22568CF | Recombinant Full Length Cercopithecus Tantalus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Colobus polykomos (Western black-and-white colobus monkey) | RFL24151CF | Recombinant Full Length Colobus Polykomos C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Erythrocebus patas (Red guenon) (Cercopithecus patas) | RFL30588EF | Recombinant Full Length Erythrocebus Patas C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Gorilla gorilla gorilla (Western lowland gorilla) | RFL14297GF | Recombinant Full Length Gorilla Gorilla Gorilla C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Homo sapiens (Human) | RFL7742HF | Recombinant Full Length Human C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352aa) | |
Hylobates moloch (Silvery gibbon) | RFL12430HF | Recombinant Full Length Hylobates Moloch C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus) | RFL28342LF | Recombinant Full Length Lophocebus Aterrimus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Macaca arctoides (Stump-tailed macaque) | RFL2096MF | Recombinant Full Length Macaca Arctoides C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | RFL8323MF | Recombinant Full Length Macaca Fascicularis C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Macaca mulatta (Rhesus macaque) | RFL34221MF | Recombinant Full Length Macaca Mulatta (Rhesus Macaque) C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Macaca nemestrina (Pig-tailed macaque) | RFL2328MF | Recombinant Full Length Macaca Nemestrina C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Mandrillus leucophaeus (Drill) (Papio leucophaeus) | RFL12648MF | Recombinant Full Length Mandrillus Leucophaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Mandrillus sphinx (Mandrill) (Papio sphinx) | RFL18955MF | Recombinant Full Length Mandrillus Sphinx C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin) | RFL32904MF | Recombinant Full Length Miopithecus Talapoin C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Mus musculus (Mouse) | RFL36863MF | Recombinant Full Length Mouse C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-354) | |
Nasalis larvatus (Proboscis monkey) | RFL17469NF | Recombinant Full Length Nasalis Larvatus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) | RFL6961NF | Recombinant Full Length Nomascus Leucogenys C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Oryctolagus cuniculus (Rabbit) | RFL10222OF | Recombinant Full Length Rabbit C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Pan paniscus (Pygmy chimpanzee) (Bonobo) | RFL9058PF | Recombinant Full Length Pan Paniscus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Pan troglodytes (Chimpanzee) | RFL4879PF | Recombinant Full Length Pan Troglodytes C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Papio anubis (Olive baboon) | RFL5405PF | Recombinant Full Length Papio Anubis C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Papio hamadryas (Hamadryas baboon) | RFL395PF | Recombinant Full Length Papio Hamadryas C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch) | RFL11067PF | Recombinant Full Length Callicebus Moloch C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL11898PF | Recombinant Full Length Pongo Abelii C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Pongo pygmaeus (Bornean orangutan) | RFL8108PF | Recombinant Full Length Pongo Pygmaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Pygathrix nemaeus (Red-shanked douc langur) | RFL21885PF | Recombinant Full Length Pygathrix Nemaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Rattus norvegicus (Rat) | RFL29360RF | Recombinant Full Length Rat C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-354) | |
Rhesus Macaque | CCR5-708R | Recombinant Rhesus monkey CCR5 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | CCR5-535R | Recombinant Rhesus Macaque CCR5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | CCR5-535R-B | Recombinant Rhesus Macaque CCR5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus) | RFL9040RF | Recombinant Full Length Rhinopithecus Avunculus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) | RFL30958RF | Recombinant Full Length Pygathrix Bieti C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Saimiri sciureus (Common squirrel monkey) | RFL21921SF | Recombinant Full Length Saimiri Sciureus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Semnopithecus entellus (Hanuman langur) (Presbytis entellus) | RFL16003SF | Recombinant Full Length Semnopithecus Entellus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Symphalangus syndactylus (Siamang) (Hylobates syndactylus) | RFL18010SF | Recombinant Full Length Hylobates Syndactylus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Theropithecus gelada (Gelada baboon) | RFL16162TF | Recombinant Full Length Theropithecus Gelada C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi) | RFL3326TF | Recombinant Full Length Trachypithecus Francoisi C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii) | RFL11986TF | Recombinant Full Length Trachypithecus Johnii C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Trachypithecus phayrei (Phayre's leaf monkey) | RFL15899TF | Recombinant Full Length Trachypithecus Phayrei C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-352) | |
Chicken | CCR5-4659C | Recombinant Chicken CCR5 | Mammalian Cell | His | ||
Kit-0889 | Hydroxyl Free Radical Assay Kit | N/A | ||||
Kit-1048 | NAD+/NADH Colorimetric Assay Kit (384-well) | N/A | ||||
Kit-1154 | CCR5 Activated GPCR Internalization Assay Kit | N/A | ||||
Kit-1153 | CCR5 CHO-K1 β-Arrestin GPCR Assay Kit | N/A | ||||
Kit-1155 | cAMP CCR5 CHO-K1 GPCR Assay Kit | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- CCR5 Related Articles
- CCR5 Related Gene Family
- CCR5 Related Research Area
CCR5 involved in several pathways and played different roles in them. We selected most pathways CCR5 participated on our site, such as Binding and entry of HIV virion, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Binding and entry of HIV virion | gag;CCR5;PPIA |
Chemokine receptors bind chemokines | ACKR4;CCRL2;CCR5;CXCR6;CCL35.1;CX3CR1;CCL19A.2;CXCL11.8;CCL27 |
Chemokine signaling pathway | GNB2;ADRBK2;CCL4L2;CXCL13;IKBKG;NRAS;RAP1B;CCL18;ROCK1 |
Class A/1 (Rhodopsin-like receptors) | GPR18;RXFP2;CCL35.2;QRFPR;SAA1;HCRT;NMBA;SSTR2;LTB4R |
Cytokine-cytokine receptor interaction | IFNB1;CCL19;LEPB;TNFRSF11A;Il6ra;CCR3;CXCL2;TNFRSF25;TP-1 |
Disease | DERL2;FMOD;EEF2;APOBEC3G;NPM1;TLR10;CPSF4;AP1G1;MIB1 |
Early Phase of HIV Life Cycle | CCR5;gag;PSIP1;PPIA;BANF1 |
Endocytosis | EHD1B;CLTCB;STAMBPA;IGF1RA;CHMP4C;BF2;KIF5AA;ASAP2A;CDC42L2 |
CCR5 has several biochemical functions, for example, C-C chemokine binding, C-C chemokine receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR5 itself. We selected most functions CCR5 had, and list some proteins which have the same functions with CCR5. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
C-C chemokine binding | CCR5;ZFP36;CCR1;DARC;CCBP2 |
C-C chemokine receptor activity | CCR1L1;CCR8;CCR7;CCR3;CCR6;CCR6A;CCR9;CCBP2;CCR5 |
actin binding | KLHL3;HIP1R;SPATA32;CAPZA1;WASB;NF2B;INPPL1;TNNI1;NCALD |
chemokine (C-C motif) ligand 5 binding | CCR5;CCR1 |
chemokine receptor activity | CCR8;CCR1;CCR9;RGRA;CXCR3.2;PRLH2R;CXCR4A;ACKR3B;CCR6A |
coreceptor activity | ZP2;ACKR3B;CD4;PVRL2;RAMP1;IGSF1;CD86;CXCR4;CCR8 |
phosphatidylinositol phospholipase C activity | CCKBR;PLCB2;PLCZ1;CCL5;PLCB1;CCR1;PLCL2;CCR5;PLCG1 |
protein binding | ZBTB2;HNRNPU;DCAF12L1;PPIE;INTS3;DNASE1;WSB1;TMEM106B;CFLAR |
virus receptor activity | HLA-DRB1;HTR2A;CLEC4M;ACE2;SLC10A1;SLC1A5;F11R;EFNB2;PVRL4 |
CCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR5.
CD4; PRAF2; CCL5; CXCR4; ARL6IP5; CCL4; MYH9; CREB3; ETV5; CTBP2; IL24
- Q&As
- Reviews
Q&As (6)
Ask a questionIn the human body, CCR5 protein is mainly involved in the regulation of the immune system, it acts as a chemokine receptor, which can sense the signal of the site of inflammation and guide immune cells to reach the site of inflammation, thus playing a role in immune response.
There are still many unsolved questions and future research directions for CCR5 protein. For example, we need to better understand the structure-function relationship of CCR5, explore the interaction of CCR5 with other proteins and their potential implications, and develop more potent and selective CCR5 antagonists.
In immunotherapy, the function of CCR5 can be used for disease treatment, such as affecting the migration and activation of immune cells by regulating the expression or function of CCR5, so as to achieve the purpose of treating inflammatory diseases or autoimmune diseases. In addition, antibodies or antagonists against CCR5 may also be considered to inhibit its binding to ligands to further modulate the immune response.
CCR5 protein can interact with other receptors and signaling pathways. For example, in some cancer cells, CCR5 binds to EGFR (epidermal growth factor receptor), triggering EGFR activation and promoting tumor cell growth and metastasis. In addition, CCR5 is also involved in the regulation of signaling pathways such as MAPK (mitogen-activated protein kinase) and PI3K (phosphatidylinositol kinase).
Gene editing technology such as CRISPR-Cas9 can be used to modify or treat the CCR5 gene. By editing the CCR5 gene, the expression of CCR5 protein can be regulated or its function can be changed. This technique is expected to be used in the future to treat some genetic diseases or cancers associated with CCR5.
One way to use CCR5 protein for disease treatment is to use CCR5 antagonists, which are drugs that prevent CCR5 from binding to ligands. There are already a number of CCR5 antagonists in clinical trials for the treatment of diseases such as AIDS and rheumatoid arthritis.
Customer Reviews (3)
Write a reviewWhen experiments are performed with CCR5, stable and reproducible results can be obtained.
CCR5 has a high yield and good economic benefits.
CCR5 exerts the expected biological effects in experiments.
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