cdc37
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  • Official Full Name
  • cell division cycle 37 homolog
  • Background
  • CDC37 is an important component of the HSP90 chaperone complex. It was initially identified for its involvement in cell-cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins. CDC3
  • Synonyms
  • CDC37; cell division cycle 37 homolog (S. cerevisiae); CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog (S. cerevisiae); hsp90 co-chaperone Cdc37; CDC37 (cell division cycle 37; S. cerevisiae; homolog)
Cat.#:CDC37-0930HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC37 Protein, GST-Tagged
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Cat.#:CDC37-3124HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDC37 Protein, MYC/DDK-tagged
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Cat.#:CDC37-11006HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC37, GST-tagged
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Cat.#:CDC37-124HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC37 protein, T7/His-tagged
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Cat.#:CDC37-26222THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC37, His-tagged
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Cat.#:CDC37-3072HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDC37, GST tagged
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Cat.#:CDC37-331HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 37 Homolog (S. cerevisiae)
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Cat.#:CDC37-403MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Cdc37, Gly & Pro tagged
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Cat.#:CDC37-417MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Cdc37, His-GST tagged
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Cat.#:CDC37-1275RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC37 Protein
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Cat.#:CDC37-6260CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC37
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Cat.#:CDC37-11269ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC37
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Cat.#:CDC37-798HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human, CDC37 His-tagged
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Cat.#:CDC37-648HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDC37 cell lysate
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Cat.#:CDC37-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CDC37 cell lysate
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Involved Pathway

CDC37 involved in several pathways and played different roles in them. We selected most pathways CDC37 participated on our site, such as AhR pathway, Constitutive Signaling by EGFRvIII, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AhR pathway
JUND; PTGES3; CDC37; FLG; CYP1A2; CDKN1A; AHR; AHRR; JUN; CYP1A1
Constitutive Signaling by EGFRvIII
CDC37
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
CDC37
Disease
AP2S1; CCR5; KPNA4; RCC1; TTR; EPM2A; CTBP1; CDK9; PACS1; NMT2
Diseases of signal transduction
CPSF6; TNKS2; TNKS; RLBP1; HEY2; HEYL; FKBP1A; RNF43; RBP1; CCNC
LKB1 signaling events
MAP2; MARK2; SIK3; STK11IP; CTSD; MARK4; CDC37
PI3K-Akt signaling pathway
COMP; EFNA4; LOC608458; LAMC3; CSF1R; CHAD; CSH; PIK3AP1; CSH2; CDC37
Signal Transduction
WIPF2; RTKN; PENKB; PDK2B; IQGAP3; ARHGAP18; FAM105B; RLN3A; KAL1A; TLE3B

Protein Function

CDC37 has several biochemical functions, for example, Hsp90 protein binding, chaperone binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC37 itself. We selected most functions CDC37 had, and list some proteins which have the same functions with CDC37. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp90 protein binding
Related Protein GBP1; HDAC6; CHORDC1; STUB1; CDC37; CSNK2A1; RPS3; PPEF2; NPAS2; HIF1A
Function chaperone binding
Related Protein BAG5; DNAJA2L; DNAJC10; DNAJB2; H2-KE2; ERP29; TIMM10; PFDN4; CDC37L1; DNAJB1
Function heat shock protein binding
Related Protein SSUH2.2; NFKB1; LIMK1; DNAJA2L; GM5506; CDC37; KCNJ11; APAF1; PPID; PDXP
Function kinase binding
Related Protein SNAI1; CTNNB1; LDHB; BARD1; TENC1; TRADD; PARK2; NTRK1; MOB4; DGKQ
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MARVELD3; TRAF2; PPEF2; DUSP19; CDC37; MAPK8IP3; MAPK1; TRAF6; STK38; MAP4K2
Function protein C-terminus binding
Related Protein LCK; CAV3; KCNIP3; ITPR1; MSH2; EP300; ERCC4; XRCC4; STIP1; TOP2A
Function protein binding
Related Protein KCNN4; MIEN1; MAGEA8; RNF34; ADAMTSL4; LATS1; FCGR2A; KLF13; TACR1; IGSF21B
Function protein kinase B binding
Related Protein ANKRD2; BAD; RARA; CCDC88A; PDE3B; TRAF6; CDC37; PINK1; APPL1; BCL10
Function protein kinase regulator activity
Related Protein KIDINS220B; APC; RAC2; CDC37; CDK5RAP1; ANKRD54; FAF1; CSNK2B; KIDINS220
Function unfolded protein binding
Related Protein GRPEL2; TOR1A; HSP26; HSPA6; NDUFAF1; HSPD1; SERPINH1; CLN3; LMAN1; DNAJA4

Interacting Protein

CDC37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC37 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC37.
HSP90AA1; LRRK2

CDC37 Related Articles

Cao, FF; Xu, LM; et al. IP-FCM Platform Detects the Existence and Regulator-Caused Dissociation of Components in Naturally Assembled HSP90 Complex. CYTOMETRY PART A 85:359-367(2014).
Du, C; Wingard, JR; et al. Serum IgG Responses against Aspergillus Proteins before Hematopoietic Stem Cell Transplantation or Chemotherapy Identify Patients Who Develop Invasive Aspergillosis. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 18:1927-1934(2012).