CDH1 Protein, cadherin 1, type 1, E-cadherin (epithelial)


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Official Full Name cadherin 1, type 1, E-cadherin (epithelial)
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Synonyms CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; Arc1; CADH1_HUMAN; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CD 234; CD324 antigen; E-Cad/CTF3; epithelial calcium dependant adhesion protein; Liver cell adhesion molecule
    • Species :
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • hIgG1
    • hIgG4
    • His
    • S
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cdh1-858M Recombinant Mouse Cdh1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDH1-0969H Recombinant Human CDH1 Protein, GST-Tagged Wheat Germ GST
    Human CDH1-1605H Recombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial) NSO N/A
    Human CDH1-198H Recombinant Human CDH1 Protein, His-tagged Insect Cell His
    Human CDH1-26935TH Recombinant Human CDH1 E.coli N/A
    Human CDH1-274H Recombinant Human CDH1, Fc tagged Human Cell N/A
    Human CDH1-275H Recombinant Human CDH1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CDH1-278H Recombinant Human CDH1, StrepII-tagged Human Cell Strep II
    Human CDH1-3118H Recombinant Human CDH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CDH1-43H Recombinant Human CDH1 Protein, His-tagged Insect Cell His
    Human CDH1-548H Recombinant Human CDH1 Protein, Fc Chimera NS0 Fc
    Human CDH1-579H Recombinant Human CDH1 protein, His & S-tagged E.coli His/S
    Human CDH1-689H Recombinant Human CDH1, His tagged Human Cell His
    Human CDH1-691H Recombinant Human CDH1 protein, His-tagged HEK293 His
    Human CDH1-86H Recombinant Human Cadherin 1, Type 1, E-cadherin (Epithelial) E.coli N/A
    Human CDH1-938HCL Recombinant Human CDH1 cell lysate Human Cell N/A
    Mouse Cdh1-1719M Recombinant Mouse Cdh1 Protein NSO N/A
    Mouse CDH1-1892MCL Recombinant Mouse CDH1 cell lysate Human Cell N/A
    Mouse Cdh1-4070M Recombinant Mouse Cdh1, His tagged Human Cell His
    Mouse Cdh1-580M Recombinant Mouse Cdh1 protein, His-tagged E.coli His
    Mouse Cdh1-581M Recombinant Mouse Cdh1 protein, His-tagged E.coli His
    Rat CDH1-1288R Recombinant Rat CDH1 Protein Mammalian Cell His
    Rat Cdh1-549R Recombinant Rat Cdh1, His-tagged Human Cell His
    Rat Cdh1-583R Recombinant Rat Cdh1 protein, His-tagged E.coli His
    Rat Cdh1-584R Recombinant Rat Cdh1 protein, His & S-tagged E.coli His/S
    Rat CDH1-736RCL Recombinant Rat CDH1 cell lysate Human Cell N/A
    Rat Cdh1-7-7477R Recombinant Rat Cdh1, His tagged Human Cell His
    Rat Cdh1-8756R Recombinant Rat Cdh1, Fc tagged Human Cell Fc
    Rhesus monkey CDH1-1737R Recombinant Rhesus Monkey CDH1 Protein HEK293 N/A
    Rhesus monkey CDH1-1738R Recombinant Rhesus Monkey CDH1 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey CDH1-1739R Recombinant Rhesus Monkey CDH1 Protein, hIgG4-tagged HEK293 hIgG4
    Chicken CDH1-3324C Recombinant Chicken CDH1 Mammalian Cell His
    Chicken CDH1-578C Recombinant Chicken CDH1 protein, His-tagged E.coli His
    Zebrafish CDH1-9331Z Recombinant Zebrafish CDH1 Mammalian Cell His
    Pig CDH1-582P Recombinant Pig CDH1 protein, His & GST-tagged E.coli His/GST

    CDH1 involved in several pathways and played different roles in them. We selected most pathways CDH1 participated on our site, such as Rap signaling pathway, Hippo signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway NRAS; ID1; Adcy4; INS1; PIK3R1; MAPK11; INSR; GNAQ; PIK3R3; PARD6B
    Hippo signaling pathway TGFB3; LATS1; FZD2; ID1; LATS2; WNT7B; WNT8B; TCF7; AREG; WNT9A
    Cell adhesion molecules (CAMs) CLDN18; Siglec1; F11R.1; CLDN11B; PVR; CNTN2; SDC2; CLDN2; ALCAMA; BLA
    Adherens junction PVRL1; PTBP3; CSNK2A2; WASLA; EP300; ACTN2B; CTNND1; MAP3K7; TGFBR2; TGFBR1
    Bacterial invasion of epithelial cells PIK3R3; CLTB; MET; ARPC5; RAC1; SEPT2; ARPC3; ARPC1B; ELMO3; SEPT1
    Pathogenic Escherichia coli infection TUBA4A; TLR5; TUBA3E; ABL1; EZR; TLR4; TUBB6; CDC42; YWHAZ; TUBA1B
    Pathways in cancer CCNE2; MTOR; WNT9B; BDKRB2; BDKRB1; LAMC1; BIRC5; LAMA2; MDM2; MAPK3
    Endometrial cancer SOS1; CTNNA3; RAF1; TCF7L2; ERBB2; CDH1; PIK3CA; MAP2K1; MLH1; PIK3R1
    Thyroid cancer LEF1; RET; TCF7; TCF7L2; MAP2K1; CCDC6; TPR; MAP2K2; RXRB; CDH1
    Melanoma FGF16; HRAS; FGF18; PIK3CG; FGF7; MAP2K2; PDGFD; PIK3R1; IGF1R; FGF3
    Bladder cancer TP53; RPS6KA5; FGFR3; MMP1; MAPK1; E2F3; ARAF; MMP1A; E2F1; SRC

    CDH1 has several biochemical functions, for example, GTPase activating protein binding, ankyrin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH1 itself. We selected most functions CDH1 had, and list some proteins which have the same functions with CDH1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activating protein binding FMNL1; GNAI3; PTBP3; TUBB; CDH1; GNAI1; PIN1; GAPVD1; MEX3B; TSC1
    ankyrin binding OBSCN; KCNJ11; SPTBN1; KCNQ2; SLC8A1; RHAG; ATP1A1; SCN5A; PTBP3; PLEC
    beta-catenin binding HDAC6; FAM123B; SLC9A3R2; EP300; APC; SLC9A3R1; CARM1; TBL1XR1; CTNNA1; Ar
    calcium ion binding ITSN2; SPOCK2; EFEMP1; PCDH15A; PLA2G10; EMR2; PLCD1; UMOD; HMCN1; EPS15
    cell adhesion molecule binding PVRL3; CDH1; LPHN1; CADM1; CADM1B; NLGN1; SELL; ITGB1; PTBP3; ITGA4
    gamma-catenin binding CTNNA1; Fert2; FER; PTPRK; DSG1; PTBP3; APC; TCF7L2; CDH1; DSG1A
    glycoprotein binding EDEM2; HSPA5; FLNA; CSNK1D; FYN; F7; SERPINA1E; CALR; RAB14; CNTN1
    protein binding AGTR1; UBE2B; HIPK1; CD14; CCDC25; RPL7; ZNF488; FMNL1; MYH8; CCDC121

    CDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH1.

    CTNNB1; EGFR; Cbll1

    Waldum, HL; Ringnes, E; et al. The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 49:974-978(2014).

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