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CDH1

  • Official Full Name

    cadherin 1, type 1, E-cadherin (epithelial)

  • Overview

    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
  • Synonyms

    CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; Arc1; CADH1_HUMAN; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CD 234; CD324 antigen; E-Cad/CTF3; epithelial calcium dependant adhesion protein; Liver cell adhesion molecule;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rat
  • Rhesus monkey
  • Xenopus laevis (African clawed frog)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • 8His
  • His
  • Fc
  • Flag
  • GST
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDH1-274H Active Recombinant Human CDH1, Fc tagged HEK293 Fc Met1-Ile707
Human CDH1-548H Active Recombinant Human CDH1 Protein, Fc Chimera Mammalian cells Fc
Human CDH1-43H Recombinant Human CDH1 Protein, His-tagged Insect Cell His
Human CDH1-26935TH Recombinant Human CDH1 E.coli N/A
Human CDH1-198H Recombinant Human CDH1 Protein, His-tagged Insect Cell His
Human CDH1-86H Recombinant Human Cadherin 1, Type 1, E-cadherin (Epithelial) E.coli N/A
Human CDH1-690H Recombinant Human CDH1 protein (Asp155-Ala709), His-tagged HEK293 His
Human CDH1-1605H Recombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial) Mammalian cells N/A
Human CDH1-691H Recombinant Human CDH1 protein, His-tagged HEK293 His Gln23-Phe647
Human CDH1-275H Recombinant Human CDH1 protein, Fc-tagged HEK293 human/IgG1/Fc 599
Human CDH1-579H Recombinant Human CDH1 protein, His & S-tagged E.coli His/S Pro373~Pro621 (Accession # P12830)
Human CDH1-0969H Recombinant Human CDH1 Protein, GST-Tagged Wheat Germ GST
Human CDH1-689H Recombinant Human CDH1, His tagged HEK293 His Met 1-Ile 707
Human CDH1-278H Recombinant Human CDH1, StrepII-tagged Human Cell Strep II 731-882, 152 a.a.
Human CDH1-938HCL Recombinant Human CDH1 cell lysate Human Cell N/A
Human CDH1-3118H Recombinant Human CDH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CDH1-5384H Recombinant Human CDH1 Protein (Met1-Ile707), C-His tagged Mammalian cells C-His Met1-Ile707
Human CDH1-6277H Recombinant Human CDH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDH1-2645H Recombinant Human CDH1 protein(791-880 aa), C-His-tagged E. coli C-His 791-880 aa
Human CDH1-0976H Recombinant Human CDH1 Protein (Asp155-Ile707), C-His tagged Mammalian cells C-His Asp155-Ile707
Human CDH1-2444H Recombinant Human CDH1 protein, His-tagged E.coli His 373-622 aa
Human CDH1-274HB Recombinant Human CDH1 Protein, hFc-tagged, Biotinylated HEK293 hFc Met1-Ile707
Human CDH1-3135HF Recombinant Full Length Human CDH1 Protein, GST-tagged In Vitro Cell Free System GST 882 amino acids
Human CDH1-2677H Recombinant Human CDH1 protein, His-tagged E.coli His 155-707aa
Human CDH1-41H Recombinant Human CDH1 Protein, C-8His tagged, Biotinylated HEK293 C-8His Q23-A709
Human CDH1-0939H Recombinant Human CDH1 Protein (Asp155-Asp367), N-His tagged E.coli N-His Asp155-Asp367
Human CDH1-214H Recombinant Human CDH1 Protein, His-tagged HEK293 His
Human CDH1-1010HFL Recombinant Full Length Human CDH1 Protein, C-Flag-tagged Mammalian cells Flag
Human CDH1-207H Recombinant Human CDH1 Protein, His-tagged HEK293 His 647
Human CDH1-208H Recombinant Human CDH1 Protein, Fc-tagged HEK293 Fc 647
Human CDH1-43H-B Recombinant Human CDH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdh1-1719M Active Recombinant Mouse Cdh1 Protein Mammalian cells N/A
Mouse Cdh1-580M Recombinant Mouse Cdh1 protein, His-tagged E.coli His Arg153~Phe264 (Accession # P09803)
Mouse Cdh1-581M Recombinant Mouse Cdh1 protein, His-tagged E.coli His Arg751~Asp884
Mouse Cdh1-4070M Recombinant Mouse Cdh1, His tagged Human Cell His
Mouse CDH1-1892MCL Recombinant Mouse CDH1 cell lysate Human Cell N/A
Mouse Cdh1-10529M-B Recombinant Mouse Cdh1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdh1-858M Recombinant Mouse Cdh1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cdh1-10529M Recombinant Mouse Cdh1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cdh1-7-7477R Recombinant Rat Cdh1, His tagged Human Cell His
Rat Cdh1-583R Recombinant Rat Cdh1 protein, His-tagged E.coli His Arg155~Phe266 (Accession # Q9R0T4)
Rat CDH1-1288R Recombinant Rat CDH1 Protein Mammalian Cell His
Rat Cdh1-8756R Recombinant Rat Cdh1 protein, hFc-tagged HEK293 hFc Met1-Ala713
Rat Cdh1-584R Recombinant Rat Cdh1 protein, His & S-tagged E.coli His/S Asp374~Ser628 (Accession # Q9R0T4)
Rat Cdh1-549R Recombinant Rat Cdh1, His-tagged Human Cell His Met1-Ala713
Rat CDH1-736RCL Recombinant Rat CDH1 cell lysate Human Cell N/A
Rat CDH1-946R Recombinant Rat CDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CDH1-946R-B Recombinant Rat CDH1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey CDH1-1737R Recombinant Rhesus Monkey CDH1 Protein HEK293 N/A
Rhesus monkey CDH1-1739R Recombinant Rhesus Monkey CDH1 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey CDH1-1738R Recombinant Rhesus Monkey CDH1 Protein, hIgG1-tagged HEK293 hIgG1
Gallus gallus (Chicken) RFL24889GF Recombinant Full Length Chicken Cadherin-1(Cdh1) Protein, His-Tagged E.coli expression system His Full Length (161-887)
Homo sapiens (Human) RFL27258HF Recombinant Full Length Human Cadherin-1(Cdh1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (155-882)
Mus musculus (Mouse) RFL732MF Recombinant Full Length Mouse Cadherin-1(Cdh1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (157-884)
Xenopus laevis (African clawed frog) RFL2432XF Recombinant Full Length Xenopus Laevis Cadherin-1(Cdh1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (149-872)
Zebrafish CDH1-9331Z Recombinant Zebrafish CDH1 Mammalian Cell His
Pig CDH1-582P Recombinant Pig CDH1 protein, His & GST-tagged E.coli His/GST Phe375~Thr631 (Accession # C6EVT4)
Chicken CDH1-3324C Recombinant Chicken CDH1 Mammalian Cell His
Chicken CDH1-578C Recombinant Chicken CDH1 protein, His-tagged E.coli His Pro784~Gly870 (Accession # P08641)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDH1 Related Articles

CDH1 involved in several pathways and played different roles in them. We selected most pathways CDH1 participated on our site, such as Rap signaling pathway, Hippo signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayPIK3R5;GNAI2;RAP1B;MRAS;CALML5;PARD6B;FGF9;PLCE1;FGFR4
Hippo signaling pathwayBTRC;WNT3A;WNT9A;PRKCI;TGFBR1;GDF5;LATS2;FGF1;BMPR2
Cell adhesion molecules (CAMs)HLA-DOB;ITGB2;CLDN4;CD274;ITGA6B;MPZL1L;CLDN5;ITGB7;CLDN10A
Adherens junctionIGF1R;ACTN3;WASLB;RAC3A;LMO7A;RAC3;PVRL1;IGF1RB;VCL
Bacterial invasion of epithelial cellsARPC1B;ARPC5;CBLB;CAV1;HCLS1;SEPT6;RAC1;CAV3;DNM1
Pathogenic Escherichia coli infectionTUBA3C;PRKCA;CDC42;RHOA;NCL;TLR4;ABL1;CTTN;OCLN
Pathways in cancerBIRC7;FIGF;Kitl;PLD1;RALBP1;MECOM;HSP90AB1;FGF12;PLEKHG5
Endometrial cancerCDH1;CTNNA3;MLH1;ILK;AXIN2;ARAF;MAP2K2;HRAS;CASP9
Thyroid cancerPPARG;MAP2K2;TCF7;LEF1;MAPK1;CCDC6;KRAS;NCOA4;TRP53
MelanomaFGF10;HGF;MAP2K1;FGF9;TRP53;HRAS;IGF1R;FGF22;Fgf15
Bladder cancerBRAF;HRAS;TYMP;NRAS;CDK4;THBS1;HBEGF;EGF;IL-8

CDH1 has several biochemical functions, for example, GTPase activating protein binding, ankyrin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH1 itself. We selected most functions CDH1 had, and list some proteins which have the same functions with CDH1. You can find most of the proteins on our site.

Function Related Protein
GTPase activating protein bindingGNAI1;PIN1;PTBP3;GNAO1;TUBB;GAPVD1;GNAI3;TSC1;FMNL1
ankyrin bindingSCN5A;FLNC;PTBP3;OBSCN;NRCAM;SLC8A1;RHCG;KCNQ2;CDH1
beta-catenin bindingPARK2;MED12;APC;TCF7L1A;HDAC6;EP300;TRPC4;GSK3B;ESR1
calcium ion bindingCHP;C1rb;PCDH15B;SPTA1;BGLAP2;AKR1C1;PCDH1GC5;PKD2L2;PVALB1
cell adhesion molecule bindingPTBP3;ITGA4;NRXN2;PVRL3;CPE;ITGB3;FGFR1;JUP;PVRL1B
gamma-catenin bindingPTPRK;DSG1;PTBP3;TCF7L2;LEF1;DSG1A;APC;FER;APC2
glycoprotein bindingFOXRED2;PIP;APOH;ACE2;TGFB1;FYN;CALR;PTBP3;ERLEC1
protein bindingSIT1;DHRS1;MTRR;SHKBP1;SERPING1;CEP70;C14orf159;FST;EEF1D

CDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH1.

CTNNB1; EGFR; Cbll1

Waldum, HL; Ringnes, E; et al. The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 49:974-978(2014).
Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How about the inheritance pattern of CDH1 gene mutations? 09/25/2019

CDH1 gene mutations are usually passed on in an autosomal dominant manner, depending on the type and location of the mutation.

What screening is required for carriers of CDH1 gene mutations? 08/03/2019

Carriers of CDH1 gene mutations should have gastroscopy, ultrasonography, and other related tests to monitor the development and progression of stomach cancer.

Can CDH1 gene mutations be prevented or treated? 06/14/2019

For people with mutations in the CDH1 gene, prophylactic total gastrectomy may reduce the risk of diffuse stomach cancer. There is currently no specific treatment to target CDH1 gene mutations.

Which gastric cancer subtypes are associated with CDH1 mutations? 04/21/2019

CDH1 gene mutation is closely related to the occurrence of diffuse gastric cancer, which is a special subtype of gastric cancer with a high degree of invasion and malignancy.

What are the effects of CDH1 gene mutations on cell adhesion and tissue differentiation? 04/01/2019

The CDH1 gene encodes a protein called E-calcin that plays an important role in cell adhesion and tissue differentiation. Mutations in the CDH1 gene may affect these processes, resulting in abnormal cell adhesion and tissue differentiation.

What is the relationship between CDH1 gene mutations and breast cancer? 03/24/2019

CDH1 gene mutations may be associated with the development of a small number of breast cancers, because CDH1 also plays a role in regulating cell adhesion and tissue structure in breast tissue.

Customer Reviews (3)

Write a review
Reviews
04/22/2022

    This recombinant protein has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.

    05/27/2020

      The protein was highly purified and was not doped with other proteins or impurities.

      05/21/2019

        CDH1 has similar activity to the native protein and is able to perform the expected biological functions.

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