| Description : |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
92.4 kDa |
| Protein Length : |
647 |
| AA Sequence : |
MGPWSRSLSALLLLLQVSSWLCQEP EPCHPGFDAESYTFTVPRRHLERGR VLGRVNFEDCTGRQRTAYFSLDTRF KVGTDGVITVKRPLRFHNPQIHFLV YAWDSTYRKFSTKVTLNTVGHHHRP PPHQASVSGIQAELLTFPNSSPGLR RQKRDWVIPPISCPENEKGPFPKNL VQIKSNKDKEGKVFYSITGQGADTP PVGVFIIERETGWLKVTEPLDRERI ATYTLFSHAVSSNGNAVEDPMEILI TVTDQNDNKPEFTQEVFKGSVMEGA LPGTSVMEVTATDADDDVNTYNAAI AYTILSQDPELPDKNMFTINRNTGV ISVVTTGLDRESFPAYTLVVQAADL QGEGLSTTATAVITVTDTNDNPPIF NPTTYKGQVPENEANVVITTLKVTD ADAPNTPAWEAVYTILNDDGGQFVV TTNPVNNDGILKTAKGLDFEAKQQY ILHVAVTNVVPFEVSLTTSTATVTV DVLDVNEAPIFVPPEKRVEVSEDFG VGQEITSYTAQEPDTFMEQKITYRI WRDTANWLEINPDTGAISTRAELDR EDFEHVKNSTYTALIIATDNGSPVA TGTGTLLLILSDVNDNAPIPEPRTI FFCERNPKPQVINIIDADLPPILAS QSIGITDMSHCTCPAPQLPAIF |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
