Recombinant Human CDH1 Protein, His-tagged
Cat.No. : | CDH1-43H |
Product Overview : | Recombinanat human CDH1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Description : | CDH1, also known as cadherin-1, is a member of cell surface glycoproteins that meditate cell adhesion. Human CDH1 shares amino acid sequence identity with the rat and mouse proteins. It is a single-pass transmembrane protein that meditates calcium-dependent epithelial cell adhesion. This protein preferentially interacts with themselves in a homophilic manner in connecting cells. It may thus contribute to the sorting of heterogeneous cell types. It is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. It is a ligand for integrin alpha-E/beta-7. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 76.6kDa (694aa)70KDa (SDS–PAGE under reducing conditions) |
AA Sequence : | EPEPCHPGFD AESYTFTVPR RHLERGRVLG RVNFEDCTGR QRTAYFSLDT RFKVGTDGVI TVKRPLRFHN PQIHFLVYAW DSTYRKFSTK VTLNTVGHHH RPPPHQASVS GIQAELLTFP NSSPGLRRQK RDWVIPPISC PENEKGPFPK NLVQIKSNKD KEGKVFYSIT GQGADTPPVG VFIIERETGW LKVTEPLDRE RIATYTLFSH AVSSNGNAVE DPMEILITVT DQNDNKPEFT QEVFKGSVME GALPGTSVME VTATDADDDV NTYNAAIAYT ILSQDPELPD KNMFTINRNT GVISVVTTGL DRESFPTYTL VVQAADLQGE GLSTTATAVI TVTDTNDNPP IFNPTTYKGQ VPENEANVVI TTLKVTDADA PNTPAWEAVY TILNDDGGQF VVTTNPVNND GILKTAKGLD FEAKQQYILH VAVTNVVPFE VSLTTSTATV TVDVLDVNEA PIFVPPEKRV EVSEDFGVGQ EITSYTAQEP DTFMEQKITY RIWRDTANWL EINPDTGAIS TRAELDREDF EHVKNSTYTA LIIATDNGSP VATGTGTLLL ILSDVNDNAP IPEPRTIFFC ERNPKPQVIN IIDADLPPNT SPFTAELTHG ASANWTIQYN DPTQESIILK PKMALEVGDY KINLKLMDNQ NKDQVTTLEV SVCDCEGAAG VCRKAQPVEA GLQIPALEHH HHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | >90% by SDS – PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Absorbance at 280nm) |
Gene Name : | CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ] |
Official Symbol : | CDH1 |
Synonyms : | CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; cadherin-1; CD324; E Cadherin; uvomorulin; CAM 120/80; E-Cadherin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; CDHE; ECAD; LCAM; Arc-1; |
Gene ID : | 999 |
mRNA Refseq : | NM_004360 |
Protein Refseq : | NP_004351 |
MIM : | 192090 |
UniProt ID : | P12830 |
Chromosome Location : | 16q22.1 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; |
Function : | GTPase activating protein binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; protein binding; |
Products Types
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CDH1-208H | Recombinant Human CDH1 Protein, Fc-tagged | +Inquiry |
CDH1-2645H | Recombinant Human CDH1 protein(791-880 aa), C-His-tagged | +Inquiry |
CDH1-3118H | Recombinant Human CDH1 Protein, MYC/DDK-tagged | +Inquiry |
CDH1-946R | Recombinant Rat CDH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CDH1-1892MCL | Recombinant Mouse CDH1 cell lysate | +Inquiry |
CDH1-938HCL | Recombinant Human CDH1 cell lysate | +Inquiry |
CDH1-736RCL | Recombinant Rat CDH1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionCDH1 gene mutations are usually passed on in an autosomal dominant manner, depending on the type and location of the mutation.
Carriers of CDH1 gene mutations should have gastroscopy, ultrasonography, and other related tests to monitor the development and progression of stomach cancer.
For people with mutations in the CDH1 gene, prophylactic total gastrectomy may reduce the risk of diffuse stomach cancer. There is currently no specific treatment to target CDH1 gene mutations.
CDH1 gene mutation is closely related to the occurrence of diffuse gastric cancer, which is a special subtype of gastric cancer with a high degree of invasion and malignancy.
The CDH1 gene encodes a protein called E-calcin that plays an important role in cell adhesion and tissue differentiation. Mutations in the CDH1 gene may affect these processes, resulting in abnormal cell adhesion and tissue differentiation.
CDH1 gene mutations may be associated with the development of a small number of breast cancers, because CDH1 also plays a role in regulating cell adhesion and tissue structure in breast tissue.
Customer Reviews (3)
Write a reviewThis recombinant protein has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.
The protein was highly purified and was not doped with other proteins or impurities.
CDH1 has similar activity to the native protein and is able to perform the expected biological functions.
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