Recombinant Full Length Human CDH1 Protein, GST-tagged

• Cat.No.: CDH1-3135HF
• Product Overview: Human CDH1 full-length ORF (ENSP00000261769, 1 a.a. - 882 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 123.9 kDa
• Protein Length: 882 amino acids
• AA Sequence: MGPWSRSLSALLLLLQVSSWLCQEP EPCHPGFDAESYTFTVPRRHLERGR VLGRVNFEDCTGRQRTAYFSLDTRF KVGTDGVITVKRPLRFHNPQIHFLV YAWDSTYRKFSTKVTLNTVGHHHRP PPHQASVSGIQAELLTFPNSSPGLR RQKRDWVIPPISCPENEKGPFPKNL VQIKSNKDKEGKVFYSITGQGADTP PVGVFIIERETGWLKVTEPLDRERI ATYTLFSHAVSSNGNAVEDPMEILI TVTDQNDNKPEFTQEVFKGSVMEGA LPGTSVMEVTATDADDDVNTYNAAI AYTILSQDPELPDKNMFTINRNTGV ISVVTTGLDRESFPTYTLVVQAADL QGEGLSTTATAVITVTDTNDNPPIF NPTTYKGQVPENEANVVITTLKVTD ADAPNTPAWEAVYTILNDDGGQFVV TTNPVNNDGILKTAKGLDFEAKQQY ILHVAVTNVVPFEVSLTTSTATVTV DVLDVNEAPIFVPPEKRVEVSEDFG VGQEITSYTAQEPDTFMEQKITYRI WRDTANWLEINPDTGAISTRAELDR EDFEHVKNSTYTALIIATDNGSPVA TGTGTLLLILSDVNDNAPIPEPRTI FFCERNPKPQVINIIDADLPPNTSP FTAELTHGASANWTIQYNDPTQESI ILKPKMALEVGDYKINLKLMDNQNK DQVTTLEVSVCDCEGAAGVCRKAQP VEAGLQIPAILGILGGILALLILIL LLLLFLRRRAVVKEPLLPPEDDTRD NVYYYDEEGGGEEDQDFDLSQLHRG LDARPEVTRNDVAPTLMSVPRYLPR PANPDEIGNFIDENLKAADTDPTAP PYDSLLVFDYEGSGSEAASLSSLNS SESDKDQDYDYLNEWGNRFKKLADM YGGGEDD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ]
• Official Symbol: CDH1
• Synonyms: CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; cadherin-1; CD324; E Cadherin; uvomorulin; CAM 120/80; E-Cadherin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; CDHE; ECAD; LCAM; Arc-1
• Gene ID: 999
• mRNA Refseq: NM_004360
• Protein Refseq: NP_004351
• MIM: 192090
• UniProt ID: P12830