cdh4
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  • Official Full Name
  • cadherin 4, type 1, R-cadherin (retinal)
  • Background
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CDH4; cadherin 4, type 1, R-cadherin (retinal); cadherin-4; R Cadherin; R-CAD; R-cadherin; retinal cadherin; cadherin 4, type 1, preproprotein; CAD4; RCAD; FLJ22202; FLJ40547; MGC126700; MGC138355
Cat.#:CDH4-0990HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH4 Protein, GST-Tagged
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Cat.#:CDH4-601HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH4, His tagged
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Cat.#:CDH4-610HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH4 Protein, His/GST-tagged
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Cat.#:CDH4-1210CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDH4
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Cat.#:CDH4-4271ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDH4
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Cat.#:CDH4-8712ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDH4
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Cat.#:CDH4-2723HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH4 cell lysate
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Involved Pathway

CDH4 involved in several pathways and played different roles in them. We selected most pathways CDH4 participated on our site, such as Adherens junctions interactions, CDO in myogenesis, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
PVRL2L; CDH10; PVRL1A; CDH7; CDH8; ANG; CDH2; PTBP3; CDH13; CDH10A
CDO in myogenesis
CDON; MYF6; TCF3A; CTNNA2; SPAG9; TCF4; CDH2; MEF2B; TCF3B; MYOD1
Cell adhesion molecules (CAMs)
ITGA8; NRXN1; NLGN1; CLDN22; NRCAM; GLYCAM1; CLDND; Siglec1; CD22; CLDNC
Cell junction organization
CDH11; CADM2; TESK1; CADM2A; CDH24; CDH12A; CDH10A; PLEC; LIMS1; CLDN3
Cell-Cell communication
SKAP2; CDH8; CDH10; FBLIM1; CD151; CDH13; CADM2; CTNND1; PLEC; JUP
Cell-cell junction organization
CDH12; ANG; CDH24; CADM2B; CDH10; CDH17; CTNND1; JUP; CLDN3; CLDN20
Developmental Biology
PEA15A; GDNF; NR2F2; SCN2A; FGFR1B; EPHB4A; LGI4; CFL1; CTNNA2; KALRNB
Myogenesis
MYOD1; TCF4; MEF2AA; MYF6; MEF2B; CDH4; TCF3B; BNIP2; CDON; BOC

Protein Function

CDH4 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH4 itself. We selected most functions CDH4 had, and list some proteins which have the same functions with CDH4. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein TGM3; BMP1A; CBLC; THBS4; S100A5; CABS1; EMR3; PCDHA9; CETN2; NRXN1

Interacting Protein

CDH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH4.
Dlg4

CDH4 Related Articles

AZZI, L; MEIJER, L; et al. PURIFICATION OF A 15-KDA CDK4-BINDING AND CDK5-BINDING PROTEIN. JOURNAL OF BIOLOGICAL CHEMISTRY 269:13279-13288(1994).