|Official Full Name||cadherin 4, type 1, R-cadherin (retinal)|
|Background||This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||CDH4; cadherin 4, type 1, R-cadherin (retinal); cadherin-4; R Cadherin; R-CAD; R-cadherin; retinal cadherin; cadherin 4, type 1, preproprotein; CAD4; RCAD; FLJ22202; FLJ40547; MGC126700; MGC138355|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDH4 involved in several pathways and played different roles in them. We selected most pathways CDH4 participated on our site, such as Adherens junctions interactions, CDO in myogenesis, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adherens junctions interactions||CDH13; CDH24; CTNNB2; CDH8; PVRL1A; CDH10A; PVRL2L; CDH10; CDH2; CDH12A|
|CDO in myogenesis||TCF3A; BOC; MEF2B; CDON; BNIP2; TCF3B; MYOD1; CDH2; TCF4; MEF2AA|
|Cell adhesion molecules (CAMs)||CLDND; NRCAM; NRXN1A; CD8B1; CNTN1; NLGN3; ITGB7; HLA-DMA; CLDN15A; ALCAMA|
|Cell junction organization||LIMS1; CLDN3; CDH9; CDH18A; CDH13; CDH8; FBLIM1; CDH5; FERMT2; CD151|
|Cell-Cell communication||DCC; DSCAM; PARVB; JUP; CDH18; CDH9; SKAP2; CDH12A; CLDN23; CADM2A|
|Cell-cell junction organization||JUP; CDH8; PVRL1A; CDH11; CDH4; PVRL2L; CLDN20; INADL; CDH12A; CADM2A|
|Developmental Biology||RND1L; BOC; RASGEF1A; SPTA1; SEMA4D; DUSP5; CACNG3; LGI1B; PCSK6; EPHB4B|
|Myogenesis||MYOG; MYF6; BOC; MEF2AA; CDH4; TCF3B; SPAG9; TCF4; TCF3A; MEF2B|
CDH4 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH4 itself. We selected most functions CDH4 had, and list some proteins which have the same functions with CDH4. You can find most of the proteins on our site.
|calcium ion binding||TNNC1; SYT11A; CALB1; S100A8; PLA2G12B; VSNL1A; PCDH21; JAG1B; CABS1; MEX3B|
CDH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH4.