|Official Full Name||cadherin 8, type 2|
|Background||This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the proteins homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.|
|Synonyms||CDH8; cadherin 8, type 2; cadherin-8; Nbla04261|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDH8 involved in several pathways and played different roles in them. We selected most pathways CDH8 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adherens junctions interactions||CDH12A; CTNNB1; CDH18A; CDH11; CDH2; CDH17; PVRL1A; CDH24; PVRL2L; CDH4|
|Cell junction organization||CD151; COL17A1A; CDH18; CDH6; CDH12; DST; CADM2; F11R.2; FERMT2; CDH13|
|Cell-Cell communication||CDH13; NPHS1; PVRL2L; CDH10A; CADM2; ITGB1B.1; SPTBN1; SIRPA; CADM2B; DCC|
|Cell-cell junction organization||CLDN16; CLDN23; CLDN7; CADM2; CDH5; CDH18; CLDN3; CDH7; PVRL1A; CLDN20|
CDH8 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH8 itself. We selected most functions CDH8 had, and list some proteins which have the same functions with CDH8. You can find most of the proteins on our site.
|calcium ion binding||PADI3; CANT1; SYT4; FREM1A; MYLPF; CDH5; RHOT1B; ANXA5A; PCDHAC2; ICN2|
CDH8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH8.