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CDK2

  • Official Full Name

    cyclin-dependent kinase 2

  • Overview

    This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
  • Synonyms

    CDK2; cyclin-dependent kinase 2; CDKN2; p33(CDK2); p33 protein kinase; cdc2-related protein kinase; cell division protein kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDK2-48H Active Recombinant Human CDK2/CCNE1 protein, GST-tagged Insect Cell GST
Human CDK2-114H Active Recombinant Human CDK2/CyclinO, GST-tagged Sf9 Insect Cell GST
Human CDK2-655H Recombinant Human cyclin-dependent kinase 2, His-tagged Insect Cell His
Human CDK2-1933H Recombinant Human CDK2 protein, His & GST-tagged E.coli His/GST Ser94~Thr198
Human CDK2-1000H Recombinant Human CDK2 Protein, GST-Tagged Wheat Germ GST
Human CDK2-172H Recombinant Human CDK2 Mammalian Cell His
Human CDK2-30287TH Recombinant Human Human CCNE1 N/A
Human CDK2-31594TH Recombinant Human Human CDK2 Sf9 Insect Cell N/A
Human CDK2-1003H Active Recombinant Human CDK2 Protein, GST-Tagged Insect Cell GST
Human CDK2-615H Recombinant Human CDK2, His tagged Insect Cell His Met 1-Leu 298
Human CDK2-797H Recombinant Human CDK2, His-tagged Human His
Human CDK2/CyclinA2-272H Recombinant Human CDK2/Cyclin A2, GST-tagged, Active Sf9 Insect Cell GST
Human CDK2-999H Recombinant Human Cyclin-Dependent Kinase 2, GST-tagged Sf9 Insect Cell GST
Human CDK2-708HCL Recombinant Human CDK2 cell lysate Insect Cell N/A
Human CDK2-3142H Recombinant Human CDK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CDK2-5392H Recombinant Human CDK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDK2-726H Recombinant Human CDK2 Protein, His-tagged E.coli N-His Gln5-Pro294
Human CDK221744H Recombinant Human CDK2 (1-298) Protein, His-tagged E.coli His
Human CDK2-472HFL Recombinant Full Length Human CDK2 Protein, C-Flag-tagged Mammalian cells Flag
Human CDK2-5875HF Active Recombinant Full Length Human CDK2 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-298(end)
Human CDK2-3178HF Recombinant Full Length Human CDK2 Protein, GST-tagged In Vitro Cell Free System GST 298 amino acids
Human CDK2-562H Recombinant Human CDK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDK2-9020HF Active Recombinant Full Length Human CDK2 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-298(end)
Human CDK2-562H-B Recombinant Human CDK2 Protein Pre-coupled Magnetic Beads HEK293
Human CDK2-8450HF Active Recombinant Full Length Human CDK2 Protein, GST-tagged Insect (sf21) GST 1-298(end)
Human CDK2-0978H Recombinant Human CDK2 Protein (Met1-Leu298), N-His tagged E.coli N-His Met1-Leu298
Human CDK2-01H Recombinant Human CDK2 Protein, His-tagged E.coli His
Mouse CDK2-3199M Recombinant Mouse CDK2 Protein Mammalian Cell His
Mouse Cdk2-1934M Recombinant Mouse Cdk2 protein, His-tagged E.coli His Gln5~Leu346 (Accession # P97377)
Mouse Cdk2-1935M Recombinant Mouse Cdk2 protein, His & GST-tagged E.coli His/GST Ala93~His211 (Accession # P97377)
Mouse Cdk2-1936M Recombinant Mouse Cdk2 protein, His & MBP-tagged E.coli His/MBP Ala93~His211 (Accession # P97377)
Mouse CDK2-1521M Recombinant Mouse CDK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDK2-1521M-B Recombinant Mouse CDK2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdk2-864M Recombinant Mouse Cdk2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cdk2-1937R Recombinant Rat Cdk2 protein, His-tagged E.coli His Ser94~Leu212 (Accession # Q63699)
Rat Cdk2-1938R Recombinant Rat Cdk2 protein, His & GST-tagged E.coli His/GST Ser94~Leu212 (Accession # Q63699)
Zebrafish CDK2-12580Z Recombinant Zebrafish CDK2 Mammalian Cell His
Chicken CDK2-4480C Recombinant Chicken CDK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDK2 Related Articles
  • CDK2 Related Research Area
  • CDK2 Related Signal Pathway

CDK2 involved in several pathways and played different roles in them. We selected most pathways CDK2 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APC/C-mediated degradation of cell cycle proteinsPSMD14;PSMD5;PSMD9;AURKB;NEK2;PSMA8;ANAPC10;CDK2;PSME3
Activation of ATR in response to replication stressRAD9B;MCM10;DBF4;RAD9A;RAD9;CLSPN;RAD17;MCM8;CDK2
Activation of the pre-replicative complexCDK2;CDT1;MCM8;DBF4;MCM10
B Cell Receptor Signaling PathwayPIK3AP1;MAP2K1;DAPP1;CDK2;STAP1;PDPK1A;cgr2b;CD19;ARPC3
BARD1 signaling eventsRAD50;CDK2;RBBP8;BARD1;CSTF1;NPM1
CDK-mediated phosphorylation and removal of Cdc6
Cell CycleTERF2;HIST2H3C;MSH5;DMC1;CDK2;CEP57;E2F6;GINS3;B9D2
Cell Cycle CheckpointsCHEK1;CHEK2;HIST3H2BB;UBE2V2;RAD9A;HIST4H4;UIMC1;BARD1;BRCC3

CDK2 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK2 itself. We selected most functions CDK2 had, and list some proteins which have the same functions with CDK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPSMC6;ATP13A;DNAJA3A;ADRBK1;IDE;PAPD4;AKT3A;ATP8B3;CDK9
cyclin bindingUSP2;CDK14;CDKN1A;PFTK1;FBXW7;CDK12;CDK6;CDK4;PTCH1
cyclin-dependent protein serine/threonine kinase activityCDK4;CDK18;CDK5;CDK9;PFTK1;CCNK;CDK11A;CDK20;CDK5R1
contributes_to histone kinase activity
metal ion bindingPFKMA;PRMT3;ALOX8;DMRT2;ACSM2B;PHYH;FTR54;NANOS1;GCM2
protein bindingC9orf116;TRIM5;LCMT1;PICALM;C7orf59;FBP1;CALCRL;RPS6KC1;HLCS
protein complex bindingIST1;PRKACA;PPP4C;TRAF2;CTSL2;CALCA;ERCC6;PTK2B;NCKAP1L

CDK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK2.

CCNA2

Shi, HL; Fu, CL; et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:2061-2070(2014).
Wang, B; Li, DP; et al. Ionizing Radiation-Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 90:53-62(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of CDK2 in cell cycle regulation? 07/10/2021

CDK2 is crucial for driving cells through the G1/S and S phases of the cell cycle.

What role does CDK2 play in cellular response to DNA damage? 05/04/2020

CDK2 helps in cell cycle arrest to allow DNA repair, preventing mutation accumulation.

What are the key regulatory mechanisms controlling CDK2 activity? 03/08/2020

CDK2 activity is controlled by cyclins, CDK inhibitors, and phosphorylation status.

How is dysregulation of CDK2 implicated in cancer development? 01/23/2020

CDK2 dysregulation can lead to uncontrolled cell proliferation, contributing to cancer.

Are there existing or potential therapeutic strategies targeting CDK2? 01/08/2020

Targeting CDK2 with specific inhibitors is explored as a potential cancer therapy strategy.

How is CDK2 activity linked to cell cycle checkpoints? 04/06/2019

It is integral to cell cycle checkpoints ensuring DNA integrity before replication.

How does CDK2 contribute to DNA replication? 02/13/2018

It phosphorylates proteins necessary for DNA replication initiation.

Customer Reviews (3)

Write a review
Reviews
04/14/2022

    Product met expectations, happy.

    03/22/2022

      High quality, reliable results.

      05/31/2021

        Outstanding performance, highly recommend.

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