|Official Full Name||cyclin-dependent kinase 2|
|Background||This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]|
|Synonyms||CDK2; cyclin-dependent kinase 2; CDKN2; p33(CDK2); p33 protein kinase; cdc2-related protein kinase; cell division protein kinase 2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDK2 involved in several pathways and played different roles in them. We selected most pathways CDK2 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|APC/C-mediated degradation of cell cycle proteins||UBE2C; ANAPC10; PSMD9; PSMD5; PSMD10; NEK2; PSME3; CDK2; PSMD14; AURKB|
|Activation of ATR in response to replication stress||DBF4; RAD9B; RAD9A; CLSPN; MCM8; MCM10; CDK2; RAD9; RAD1; CHEK1|
|Activation of the pre-replicative complex||CDT1; CDK2; DBF4; MCM8; MCM10|
|B Cell Receptor Signaling Pathway||HDAC5; ITPR2; IKBKB; GSK3B; DAPP1; MALT1; NRAS; VAV1; RAF1; CARD11|
|BARD1 signaling events||CDK2; NPM1; BARD1; RBBP8; CSTF1; RAD50|
|CDK-mediated phosphorylation and removal of Cdc6||CDK2|
|Cell Cycle||PMF1; CSNK1E; MCM9; CKAP5; NDC80; TTK; HUS1; CDKN1BA; SDCCAG8; MLF1IP|
|Cell Cycle Checkpoints||RAD9; CDK2; DBF4; BARD1; BABAM1; TP53BP1; HIST3H2BB; CLSPN; CDKN1B; MCM8|
CDK2 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK2 itself. We selected most functions CDK2 had, and list some proteins which have the same functions with CDK2. You can find most of the proteins on our site.
|ATP binding||CLK1; ATP2B4; PDIK1L; PANK1B; HSPA9; DGKE; CSNK1D; STK38A; GRK7B; GART|
|cyclin binding||CDK6; CUL3; MDFIC; CDK5RAP3; USP2; PFTK1; CDK13; INCA1; FBXW7; HDAC3|
|cyclin-dependent protein serine/threonine kinase activity||CDKL5; CDKL1; CDK16; CDK5; CDK12; CDK5R1; CDKL3; STK30; CCND3; CDK1|
|contributes_to histone kinase activity||CDK2|
|metal ion binding||NKD2A; DMRTA1; REV1; IKZF1; OMA1; GM12824; TRERF1; SMYD4; MAP3K3; CYP51|
|protein binding||MKKS; VEPH1; MLF1; SZT2; HMG20B; NSMAF; OSR2; MELK; ATP2A1; FABP5|
|protein complex binding||PRKACA; LEPRE1; C8A; BRK1; AP2A2; STRN4; HADHA; RPTOR; SHARPIN; RAP1A|
CDK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK2.