cdk2
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  • Official Full Name
  • cyclin-dependent kinase 2
  • Background
  • This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
  • Synonyms
  • CDK2; cyclin-dependent kinase 2; CDKN2; p33(CDK2); p33 protein kinase; cdc2-related protein kinase; cell division protein kinase 2;
Cat.#:CDK2/CyclinA2-272HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK2/Cyclin A2, GST-tagged, Active
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Cat.#:CDK2-1000HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK2 Protein, GST-Tagged
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Cat.#:CDK2-1003HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK2 Protein, GST-Tagged
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Cat.#:CDK2-3142HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK2 Protein, MYC/DDK-tagged
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Cat.#:CDK2-114HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK2/CyclinO, GST-tagged
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Cat.#:CDK2-172HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CDK2
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Cat.#:CDK2-1933HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK2 protein, His & GST-tagged
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Cat.#:CDK2-30287THTag:
Source (Host):Species:Human
Product nameRecombinant Human Human CCNE1
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Cat.#:CDK2-31594THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Human CDK2
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Cat.#:CDK2-48HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CDK2/CCNE1 protein, GST-tagged
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Cat.#:CDK2-615HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK2, His tagged
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Cat.#:CDK2-655HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human cyclin-dependent kinase 2, His-tagged
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Cat.#:Cdk2-1934MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk2 protein, His-tagged
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Cat.#:Cdk2-1935MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk2 protein, His & GST-tagged
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Cat.#:Cdk2-1936MTag:His/MBP
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk2 protein, His & MBP-tagged
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Cat.#:CDK2-3199MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK2 Protein
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Cat.#:Cdk2-1937RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdk2 protein, His-tagged
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Cat.#:Cdk2-1938RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdk2 protein, His & GST-tagged
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Cat.#:CDK2-4480CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK2
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Cat.#:CDK2-12580ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK2
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Cat.#:CDK2-797HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK2, His-tagged
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Cat.#:CDK2-999HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 2, GST-tagged
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Cat.#:CDK2-708HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK2 cell lysate
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Involved Pathway

CDK2 involved in several pathways and played different roles in them. We selected most pathways CDK2 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC/C-mediated degradation of cell cycle proteins
PSMA8; UBE2C; PSMD5; PSMD10; CDK2; NEK2; PSMD14; AURKB; PSMD9; ANAPC10
Activation of ATR in response to replication stress
RAD1; MCM8; DBF4; RAD17; CLSPN; HUS1; MCM10; CHEK1; CDK2; RAD9A
Activation of the pre-replicative complex
MCM8; MCM10; CDT1; DBF4; CDK2
B Cell Receptor Signaling Pathway
NFKBIE; BLK; ARPC4; FOS; CD72; CRKL; DUSP6; BTK; PTPN18; LAT2
BARD1 signaling events
BARD1; RAD50; CSTF1; NPM1; RBBP8; CDK2
CDK-mediated phosphorylation and removal of Cdc6
CDK2
Cell Cycle
CSNK2B; SKA1; ORC3; NDEL1B; RCC2; PMF1; MAD1L1; NUP35; RBBP8; CDCA5
Cell Cycle Checkpoints
CHEK1; RNF168; RAD1; FAM175A; CHEK2; UIMC1; DBF4; MCM10; KAT5; RAD9B

Protein Function

CDK2 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK2 itself. We selected most functions CDK2 had, and list some proteins which have the same functions with CDK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PCCB; MARK1; STK10; MTHFD1B; CSNK1G2B; CMPK1; CPS1; EPHB3A; DDX3X; TSSK4
Function cyclin binding
Related Protein CDK13; PTCH1; CDK4; MDFIC; HDAC3; CDK5RAP3; PFTK1; CDKN1A; CDK6; CUL3
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK9; CDK18; CDK6; CCND3; CDK13; CDK7; CDKL4; ICK; CDK15; CDK12
Function contributes_to histone kinase activity
Related Protein CDK2
Function metal ion binding
Related Protein TRIM8A; CEPT1; SMAD2; SMAD6; ZNF800; HEPHL1; ZFYVE27; HE1A; FGD4; RXFP1
Function protein binding
Related Protein SMIM3; PDCD2; C16orf48; ARHGEF10; IL7; DAG1; CTNNBL1; CIRBP; MPP7; AKAP8L
Function protein complex binding
Related Protein CALY; UQCRC2; BRK1; FGFR1; ITGB1BP1; PPIB; CPS1; ATG101; TWF1; NFKBIA

Interacting Protein

CDK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK2.
CCNA2

CDK2 Related Articles

Shi, HL; Fu, CL; et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:2061-2070(2014).
Wang, B; Li, DP; et al. Ionizing Radiation-Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 90:53-62(2014).