CDK8 Protein, cyclin-dependent kinase 8


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Official Full Name cyclin-dependent kinase 8
Background The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members;are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are;known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are;components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the;largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the;CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the;Mediator-like protein complexes and the basal transcription machinery.
Synonyms CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK8/CCNC-256H Recombinant Human CDK8/CCNC, GST&His-tagged Sf9 Insect Cell GST/His
    Human CDK8-08H Recombinant Human CDK8, His-tagged E.coli N/A
    Human CDK8-1003H Recombinant Human Cyclin-Dependent Kinase 8, GST-tagged Sf9 Insect Cell GST
    Human CDK8-1038H Recombinant Human CDK8 Protein, GST-Tagged Insect Cell GST
    Human CDK8-1039H Recombinant Human CDK8 Protein, His-Tagged Insect Cell His
    Human CDK8-10H Recombinant Human CDK8, MYC/DDK-tagged HEK293 Myc/DDK
    Human CDK8-11H Recombinant Human CDK8, GST-tagged Wheat Germ GST
    Human CDK8-7620HCL Recombinant Human CDK8 293 Cell Lysate HEK293 N/A
    Mouse CDK8-3212M Recombinant Mouse CDK8 Protein Mammalian Cell His
    Rhesus Macaque CDK8-790R Recombinant Rhesus monkey CDK8 Protein, His-tagged Mammalian Cell His
    Zebrafish CDK8-9758Z Recombinant Zebrafish CDK8 Mammalian Cell His

    CDK8 involved in several pathways and played different roles in them. We selected most pathways CDK8 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants CDK8; HEYL; HDAC5; MIB1; JAG2; HEY2; HEY1; ADAM10; JAG1; HDAC6
    Constitutive Signaling by NOTCH1 PEST Domain Mutants CCNC; JAG2; HDAC6; CDK8; HEYL; HEY2; JAG1; ADAM10; HDAC5; MIB1
    Developmental Biology FRS2A; NRG2A; SEMA3AA; BNIP2; CDH4; ACTR2B; MED26; GFRA2; DUSP2; CSNK2A2
    Disease FDX1; AP2B1; OGN; AP1G1; CDK8; TIRAP; CFTR; NA; HMGA1; CDK9
    Diseases of signal transduction MIB1; LRRFIP1; HEY1; STRA6; TTR; RNF43; CUX1; CCNC; FGFR1OP; TNKS
    Fatty acid, triacylglycerol, and ketone body metabolism HELZ2; TMEM195; CCNC; SREBF2; MED8; ACSF2; APOA5; ACOT9.2; CTGF; CPT2
    Gene Expression NR6A1A; ZNF398; ZNF394; HBXIP; RARG; SF3A1; LCMT2; ZNF771; GTF3C3; ZNF256
    Generic Transcription Pathway ZNF777; COX6C; NR2F1; KRBA1; ZNF398; MED23; CCNT2A; ZNF738; ZNF596; ZNF480

    CDK8 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK8 itself. We selected most functions CDK8 had, and list some proteins which have the same functions with CDK8. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding HSPA1A; NOLC1; KTI12; DDX52; ETNK2; TSSK2; PSMC1; TMEM38A; GUCY2E; AAK1
    RNA polymerase II carboxy-terminal domain kinase activity CDK13; MAPK1; CDK7; CDK1; CDK8; CDK12; CCNK; CDK9
    cyclin-dependent protein serine/threonine kinase activity CCNK; PFTK1; CDK17; CDK14; NAT1; CDK13; STK30; MAK; CDK3; CDKL5
    protein binding CRH; PRPF8; C16orf72; SH3BP1; ASAP3; SNX4; RPS10; RHBDL1; PDE3B; ITGB4
    protein kinase activity TAOK1; TNK2B; AKT2L; PIK3R4; ACVR1; MAP3K12; SCYL2; STK24; FGFR1A; GC2
    ubiquitin protein ligase activity UBE2G1B; RNF24; TRIM59; SIAH1A; CDK8; RNF13; HERC2; AKTIP; RNF25; PDZRN4

    CDK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK8.


    Qu, XL; Li, XL; et al. Regulation of Renal Fibrosis by Smad3 Thr388 Phosphorylation. AMERICAN JOURNAL OF PATHOLOGY 184:944-952(2014).
    Rovnak, J; Quackenbush, SL; et al. Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme. JOURNAL OF VIROLOGY 76:8031-8039(2002).

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