cdk8
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  • Official Full Name
  • cyclin-dependent kinase 8
  • Background
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members;are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are;known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are;components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the;largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the;CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the;Mediator-like protein complexes and the basal transcription machinery.
  • Synonyms
  • CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075
Cat.#:CDK8-1038HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK8 Protein, GST-Tagged
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Cat.#:CDK8-1039HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK8 Protein, His-Tagged
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Cat.#:CDK8-08HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK8, His-tagged
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Cat.#:CDK8/CCNC-256HTag:GST|His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK8/CCNC, GST&His-tagged
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Cat.#:CDK8-10HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK8, MYC/DDK-tagged
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Cat.#:CDK8-11HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CDK8, GST-tagged
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Cat.#:CDK8-3212MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK8 Protein
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Cat.#:CDK8-790RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK8 Protein, His-tagged
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Cat.#:CDK8-9758ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK8
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Cat.#:CDK8-1003HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 8, GST-tagged
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Cat.#:CDK8-7620HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CDK8 293 Cell Lysate
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Involved Pathway

CDK8 involved in several pathways and played different roles in them. We selected most pathways CDK8 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
JAG1; HDAC6; CCNC; MIB1; ADAM10; HEYL; HEY2; JAG2; HDAC5; CDK8
Constitutive Signaling by NOTCH1 PEST Domain Mutants
CCNC; HEY1; HEYL; MIB1; HDAC5; HEY2; HDAC6; JAG1; ADAM10; JAG2
Developmental Biology
PAK4; CLASP1; CLTB; MED19; EFNA1; KLB; EFNA3B; SIAH2; TCF3B; NRG2A
Disease
ELL; GPC6; ARF1; MMAA; RBP1; HEY1; AP2B1; CCDC59; KPNA4; MMADHC
Diseases of signal transduction
LRRFIP1; CTBP1; TNKS; TNKS2; JAG1; CTBP2; OPN1MW2; CUX1; FGFR1OP; TRIM24
Fatty acid, triacylglycerol, and ketone body metabolism
CYP4A11; PPARGC1B; CTGF; MED20; ACOT11A; CCNC; ACOT13; ABCA1; MED7; APOA5
Gene Expression
SAP30L; ANP32A; SESN3; GPR19; RARG; MED13A; MED25; ZNF426; ZNF136; DNAJC8
Generic Transcription Pathway
ZNF100; ZNF550; NRBP1; ZFP90; RNF111; NR2F1A; ZNF461; ZNF18; NR1H3; ZNF544

Protein Function

CDK8 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK8 itself. We selected most functions CDK8 had, and list some proteins which have the same functions with CDK8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MCM4; PLK4; AURKA; DDX17; EPHB1; PAK1; SGK1; PRKD2; ABCE1; HSPA2
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK9; CDK1; CDK8; MAPK1; CDK12; CDK7; CDK13; CCNK
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein MAK; CCNK; CDK18; CDK3; CDK8; CDK17; CDKL4; CDK2; CDK4; STK30
Function protein binding
Related Protein ACYP2; KRT86; YWHAZ; SYCE2; CIT; ATXN3; GRID2IP; DLA; FAM54A; ZFP335
Function protein kinase activity
Related Protein BMPR1AA; CAMK2D2; CASKA; PRKG1A; PRKAA1; LMTK2; CCL8; SBK1; CCL5; NEK4
Function ubiquitin protein ligase activity
Related Protein PPIL2; CCNB1IP1; UHRF1; RNF175; HECW2; PDZRN4; RNF115; RNF144AB; TRIM3; TRAF6

Interacting Protein

CDK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK8.
CCNC

CDK8 Related Articles

Qu, XL; Li, XL; et al. Regulation of Renal Fibrosis by Smad3 Thr388 Phosphorylation. AMERICAN JOURNAL OF PATHOLOGY 184:944-952(2014).
Rovnak, J; Quackenbush, SL; et al. Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme. JOURNAL OF VIROLOGY 76:8031-8039(2002).