|Official Full Name||cyclin-dependent kinase 8|
|Background||The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members;are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are;known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are;components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the;largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the;CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the;Mediator-like protein complexes and the basal transcription machinery.|
|Synonyms||CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDK8 involved in several pathways and played different roles in them. We selected most pathways CDK8 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants||CDK8; HEYL; HDAC5; MIB1; JAG2; HEY2; HEY1; ADAM10; JAG1; HDAC6|
|Constitutive Signaling by NOTCH1 PEST Domain Mutants||CCNC; JAG2; HDAC6; CDK8; HEYL; HEY2; JAG1; ADAM10; HDAC5; MIB1|
|Developmental Biology||FRS2A; NRG2A; SEMA3AA; BNIP2; CDH4; ACTR2B; MED26; GFRA2; DUSP2; CSNK2A2|
|Disease||FDX1; AP2B1; OGN; AP1G1; CDK8; TIRAP; CFTR; NA; HMGA1; CDK9|
|Diseases of signal transduction||MIB1; LRRFIP1; HEY1; STRA6; TTR; RNF43; CUX1; CCNC; FGFR1OP; TNKS|
|Fatty acid, triacylglycerol, and ketone body metabolism||HELZ2; TMEM195; CCNC; SREBF2; MED8; ACSF2; APOA5; ACOT9.2; CTGF; CPT2|
|Gene Expression||NR6A1A; ZNF398; ZNF394; HBXIP; RARG; SF3A1; LCMT2; ZNF771; GTF3C3; ZNF256|
|Generic Transcription Pathway||ZNF777; COX6C; NR2F1; KRBA1; ZNF398; MED23; CCNT2A; ZNF738; ZNF596; ZNF480|
CDK8 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK8 itself. We selected most functions CDK8 had, and list some proteins which have the same functions with CDK8. You can find most of the proteins on our site.
|ATP binding||HSPA1A; NOLC1; KTI12; DDX52; ETNK2; TSSK2; PSMC1; TMEM38A; GUCY2E; AAK1|
|RNA polymerase II carboxy-terminal domain kinase activity||CDK13; MAPK1; CDK7; CDK1; CDK8; CDK12; CCNK; CDK9|
|cyclin-dependent protein serine/threonine kinase activity||CCNK; PFTK1; CDK17; CDK14; NAT1; CDK13; STK30; MAK; CDK3; CDKL5|
|protein binding||CRH; PRPF8; C16orf72; SH3BP1; ASAP3; SNX4; RPS10; RHBDL1; PDE3B; ITGB4|
|protein kinase activity||TAOK1; TNK2B; AKT2L; PIK3R4; ACVR1; MAP3K12; SCYL2; STK24; FGFR1A; GC2|
|ubiquitin protein ligase activity||UBE2G1B; RNF24; TRIM59; SIAH1A; CDK8; RNF13; HERC2; AKTIP; RNF25; PDZRN4|
CDK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK8.