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CENPE

Official Full Name

centromere protein E, 312kDa
Overview

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]
Synonyms

CENPE; centromere protein E, 312kDa; KIF10; CENP-E; PPP1R61; centromere-associated protein E; kinesin family member 10; kinesin-related protein CENPE; Centromere autoantigen E (312kD); protein phosphatase 1, regulatory subunit 61;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CENPE-1114H	Recombinant Human CENPE Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CENPE-348H	Recombinant Human CENPE Protein, His-tagged	E.coli	His	Ala2450~Arg2590	Inquiry
Human	CENPE-3800H	Recombinant Human CENPE protein, His-tagged	E.coli	His	2401-2500 aa	$319 / 25ug
Rat	Cenpe-349R	Recombinant Rat Cenpe Protein, His-tagged	E.coli	His	Ala2222~Arg2361	Inquiry
Zebrafish	CENPE-4563Z	Recombinant Zebrafish CENPE	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CENPE involved in several pathways and played different roles in them. We selected most pathways CENPE participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	CENPJ;DCTN1;PANE1;CENPL;NEDD1;BUB1B;AHCTF1;ATM;CCNB2
Cell Cycle, Mitotic	CEP290;LEMD3;LIN9;MCM10;MAPRE1B;CSNK2A2;DHFR;GINS2;SETA
Factors involved in megakaryocyte development and platelet production	CBX5;MAFF;HMG20B;KIF22;DOCK1;DOCK10;H3F3D;LRRC16A;EHD1
Hemostasis	CD9B;Alb;PHF21A;DGKB;APOER2;KIF5B;RHOGA;F3A;F9B
Kinesins	KIF11;KLC3;KIF4;KIF4A;RACGAP1;KIF22;KIF26A;KIF20A;KIF3B
M Phase	ARPP19A;VRK2;NDC80;DULLARD;CNEP1R1;SMC4;NDEL1A;NUF2;SGOL2
Mitotic Anaphase	PMF1;CENPP;KNTC1;PDS5A;SPC25;SKA2;NUDC;B9D2;RANGAP1B
Mitotic Metaphase and Anaphase	B9D2;NUDC;LEMD3;PANE1;CENPC1;ITGB3BP;VRK2;CENPH;RANGAP1B

CENPE has several biochemical functions, for example, ATP binding, ATPase activity, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPE itself. We selected most functions CENPE had, and list some proteins which have the same functions with CENPE. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ABCB6A;SGK2A;ERBB4A;RIPK3;ASS1;ACTB;UCK2B;MYO1H;CMPK
ATPase activity	ATAD1A;ABCF2;KIF27;ABCD1;ATP13A3;KIF21A;KIF1B;DNAH5;DNAHC8
microtubule binding	MID1;GCAP14;KIF4A;GOLSYN;MTAP7D3;MAP4;MAP1LC3C;KIF7;MAPRE2
microtubule motor activity	KIF23;KIF14;KIF13B;KLC1B;KIF2A;KIF15;KIF5C;KIF4A;DYNC1H1
nucleotide binding	RAVER1;TIA1;NPR1A;TIAL1;RBM8A;TIA1L;CKBB;PUF60;ORC5

CENPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPE here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPE.