ckap5
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  • Official Full Name
  • cytoskeleton associated protein 5
  • Background
  • This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • CKAP5; cytoskeleton associated protein 5; cytoskeleton-associated protein 5; ch TOG; KIAA0097; TOG; TOGp; colonic and hepatic tumor overexpressed gene protein; colonic and hepatic tumor over-expressed gene protein; MSPS; CHTOG; ch-TOG; FLJ35359
Cat.#:CKAP5-3493MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CKAP5 Protein
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Cat.#:CKAP5-4439CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CKAP5
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Cat.#:CKAP5-3565ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CKAP5
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Involved Pathway

CKAP5 involved in several pathways and played different roles in them. We selected most pathways CKAP5 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
TMEM67; CEP57; CEP97; TCTN3; B9D2; CP110; OFD1; NDE1; NEDD1; CEP290
Assembly of the primary cilium
KIFAP3B; IFT27; MAPRE1B; CLASP1; IFT172; IFT80; DCTN3; FBF1; CYS1; CEP70
Cell Cycle
CENPQ; NUDC; GADD45AB; MIS12; PLK4; ATM; SMC1B; HIST4H4; CENPI; MCM7
Cell Cycle, Mitotic
CDKN2C; DCTN2; LMNB1; ZWILCH; CP110; H3F3D; NIPBLA; CENPP; KIF18A; E2F4
Centrosome maturation
PCM1; TSGA14; CEP63; NINL; SSNA1; CEP57; PLK4; SDCCAG8; MAPRE1; ODF2
G2/M Transition
SSNA1; PLK4; CCP110; CEP72; DCTN3; DCTN2; LIN9; CP110; TSGA14; CDK11B
Loss of Nlp from mitotic centrosomes
MAPRE1A; CKAP5; CEP78; CLASP1A; CCP110; CEP290; CEP135; CEP72; TUBG1; SDCCAG8
Loss of proteins required for interphase microtubule organizationfrom the centrosome
MAPRE1A; ODF2B; MAPRE1B; PCM1; CENPJ; CP110; NINL; SDCCAG8; TUBG1; CEP78

Protein Function

CKAP5 has several biochemical functions, for example, microtubule binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CKAP5 itself. We selected most functions CKAP5 had, and list some proteins which have the same functions with CKAP5. You can find most of the proteins on our site.
Function
Related Protein
Function microtubule binding
Related Protein MAP6D1; CASC1; KIF2B; HAUS8; KIF3B; SGIP1; GABARAPA; MAP1LC3C; MTAP1A; VPS41
Function ribonucleoprotein complex binding
Related Protein RNASEL; UHMK1; PES; PRMT5; ITCH; SECISBP2; PITX2; TIMM50; PES1; SRP54

Interacting Protein

CKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CKAP5.
TACC3; b2rcx0_human; q8iw51; APC; CKAP5; DYNC1H1; CCHCR1; RBPMS; ACADM; SLAIN2; TACC2; ERLIN1; HSPD1; PC; KRT5; ATP5A1; LONP1; ETFB; MTOR

CKAP5 Related Articles

Morielli, T; O'Flaherty, C; et al. Oxidative stress impairs function and increases redox protein modifications in human spermatozoa. REPRODUCTION 149:113-123(2015).
de Leon, CTG; Martin, RDD; et al. Proteomic characterization of the subpellicular cytoskeleton of Toxoplasma gondii tachyzoites. JOURNAL OF PROTEOMICS 111:86-99(2014).