|Official Full Name||Claudin 15|
|Background||This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease.|
|Synonyms||Cldn15; claudin 15; claudin-15; BB107105; 2210009B08Rik|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CLDN15 involved in several pathways and played different roles in them. We selected most pathways CLDN15 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cell adhesion molecules (CAMs)||CD2; NTNG1; HLA-DRB4; ITGB2; ITGAM; HLA-DPB1; HLA-E; CLDN7; CLDNH; ITGAV|
|Tight junction||SHROOM2; HCLS1; TJP1; JAM3B; RHOAA; CLDN1; SHROOM3; SMYHC1; CLDN7B; CLDN14|
|Leukocyte transendothelial migration||ACTG1; ARHGAP5; CTNNA3; RAP1A; CLDN14; CXCR4; CLDN7; PIK3R2; Itgam&Itgb2; CLDN8|
|Hepatitis C||PPP2CB; CLDN15; ARAF; IFNA7; TNF; STAT2; IRF9; IKBKG; OAS3; EIF2AK4|
CLDN15 has several biochemical functions, for example, identical protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN15 itself. We selected most functions CLDN15 had, and list some proteins which have the same functions with CLDN15. You can find most of the proteins on our site.
|identical protein binding||TTC32; DLC; TRAF2; C1S; ALCAMA; DNM1L; CORO1B; C14orf166; BNIPL; DNM1|
|structural molecule activity||CLDNG; KRT77; MAP7D1B; BGLAP; CLDN16; LMNB1; SPRR2A; NEFMA; CLDNF; CLTCA|
CLDN15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN15 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN15.