clec4m
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  • Official Full Name
  • C-type lectin domain family 4, member M
  • Background
  • This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
  • Synonyms
  • CLEC4M; C-type lectin domain family 4, member M; CD209L, CD299, CD299 antigen; C-type lectin domain family 4 member M; DC SIGN2; DC SIGNR; DCSIGNR; HP10347; LSIGN; C type lectin domain family 4, member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; DC SIGN related protein; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866; mannose binding C-type lectin DC-SIGNR; liver/lymph node-specific ICAM-3 grabbing non-integrin
Cat.#:CLEC4M-1471HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLEC4M Protein, GST-tagged
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Cat.#:CLEC4M-3263HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC4M Protein, MYC/DDK-tagged
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Cat.#:CLEC4M-1855HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLEC4M protein, His & T7-tagged
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Cat.#:CLEC4M-230HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC4M Protein
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Cat.#:CLEC4M-26929THTag:FC
Source (Host):Species:Human
Product nameRecombinant Human CLEC4M, FC-tagged
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Cat.#:CLEC4M-3132HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC4M, Fc tagged
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Cat.#:CLEC4M-689HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CLEC4M, Fc Chimera
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Cat.#:CLEC4M-2744HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC4M cell lysate
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Involved Pathway

CLEC4M involved in several pathways and played different roles in them. We selected most pathways CLEC4M participated on our site, such as Measles, Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Measles
FASLG; TRAF6; HSPA1B; Il2; IFNA14; IFNA6; PIK3CA; Ifna15; IRF7; BBC3
Phagosome
CCDC102A; TUBA4L; MPO; ATP6V0A2B; SEC22BA; OLR1; VAMP3; HGS; DYNC1I1; ITGB2L
Tuberculosis
HLA-DQA1; ATP6V0A4; CALM2; RFXAP; Cd209g; FCGR2A; FCGR3; PPP3CA; CEBPG; ATP6AP1

Protein Function

CLEC4M has several biochemical functions, for example, ICAM-3 receptor activity, calcium-dependent protein binding, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4M itself. We selected most functions CLEC4M had, and list some proteins which have the same functions with CLEC4M. You can find most of the proteins on our site.
Function
Related Protein
Function ICAM-3 receptor activity
Related Protein ITGAL; ITGB2; CLEC4M
Function calcium-dependent protein binding
Related Protein VPS37C; MMP13; DMBT1; CASQ2; ANXA4; MBL2; KCNIP3; STMN2; ANXA3; PDCD6
Function carbohydrate binding
Related Protein CLEC12A; Siglece; PRG2; KLRB1A; PKD1L2; WBSCR17; CD209; LGALS13; NOMO2; CALR3
Function mannose binding
Related Protein MRC1; CD209A; CD207; CD209; Acr; IGF2R; MBL2; M6PR; MBL1; BSG
Function metal ion binding
Related Protein ZFP451; TNFRSF11A; NUBPL; ARMC1L; INSM1A; ECE2; ZBTB8OS; XPA; ZNF823; APTX
Function peptide antigen binding
Related Protein HLA-B; MHC1UKA; HLA-DPA1; MHC1ZKA; HLA-DRB5; HLA-DRB3; HLA-DQA1; MHC1UDA; H2-AA; MHC1UHA
Function receptor activity
Related Protein KRT1; CALCR; EPHB6; MED12; ITGB1B.2; CD200R4; PROCR; ADIPOR1; SEC63; ITGB1A
Function virion binding
Related Protein TSG101; HSP90B1; PVRL1; PTX3; PPIA; HIPK2; CD209; CLEC4M; APCS
Function virus receptor activity
Related Protein SLC1A5; SLC52A2; CD46; CLDN1; HLA-DRB1; SERPINB4; CXADR; NPC1; XPR1; NCAM1

Interacting Protein

CLEC4M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4M here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4M.
ITGAM; CEACAM1; q03463-pro_0000278734; MME