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CLK2

  • Official Full Name

    CDC-like kinase 2

  • Overview

    This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]
  • Synonyms

    CLK2; CDC-like kinase 2; hCLK2; dual specificity protein kinase CLK2; CLK kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Assay Kits
  • Chicken
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • B2M
  • SUMO
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLK2-1005H Recombinant Human CDC-Like Kinase 2, GST-tagged Sf9 Insect Cell GST
Human CLK2-1493H Active Recombinant Human CLK2 Protein, GST-tagged Insect Cell GST
Human CLK2-285H Recombinant Human CDC-like Kinase 2, GST-tagged, Active Sf9 Insect Cell GST
Human CLK2-1494H Recombinant Human CLK2 Protein, GST-tagged Wheat Germ GST
Human CLK2-11334H Recombinant Human CLK2, GST-tagged E.coli GST C-term-300a.a.
Human CLK2-7440HCL Recombinant Human CLK2 293 Cell Lysate HEK293 N/A
Human CLK2-2703H Recombinant Human CLK2 protein, His-SUMO-tagged E.coli His-SUMO 138-499aa
Human CLK2-2704H Recombinant Human CLK2 protein, His-B2M-tagged E.coli His-B2M 138-499aa
Human CLK2-4343HF Active Recombinant Full Length Human CLK2 Protein, GST-tagged Insect (sf21) GST 1-499
Human CLK2-0392H Recombinant Human CLK2 Protein (R130-D496), Tag Free E.coli No tag R130-D496
Human CLK2-2204HF Recombinant Full Length Human CLK2 Protein, GST-tagged In Vitro Cell Free System GST 498 amino acids
Human CLK2-0393H Recombinant Human CLK2 Protein (R130-D496), GST tagged E.coli GST R130-D496
Human CLK210047H Recombinant Human CLK2 (136-496) Protein, His-tagged E.coli His
Chicken CLK2-2980C Recombinant Chicken CLK2 Mammalian Cell His
Kit-1572 CLK2 Kinase Binding Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLK2 involved in several pathways and played different roles in them. We selected most pathways CLK2 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA processingRBM4B;ZFML;TXNL4A;SF3A1;OASL2;PRPF4BB;FAM120B;DDX20;CLASRP

CLK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK2 itself. We selected most functions CLK2 had, and list some proteins which have the same functions with CLK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKG2;NLRP5;ATP11A;PIK3C2A;MAPKAPK2A;TTLL11;TIMM44;GTF2F2A;NLRC4
protein bindingPKD2;SPINK1;TAF1B;ATXN7L1;IRS4;HSPA1B;UBL7;KRTAP12-2;USP10
protein serine/threonine kinase activityNEK3;FAM20C;STK19;PRPF4B;WNK2;HIPK1;DYRK2;WNK1;GRK1A
protein serine/threonine/tyrosine kinase activityMAP2K2;CLK4;DYRK1B;DYRK4;AKT1;DYRK3;RPS6KB1;PRKACA;SGK1
protein tyrosine kinase activityPTK6B;RET;EGFRA;BLK;WEE1;WEE2;TYK2;DYRK1A;FGR

CLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK2.

CLK3; RBM39; SNIP1; YWHAG

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