Recombinant Human CDC-Like Kinase 2, GST-tagged

• Cat.No.: CLK2-1005H
• Product Overview: Recombinant human CLK2 (137-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 137-end a.a.
• Description: CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 68 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 52 nmol/min/mg
• Purity: > 80 %
• Concentration: 0.1 ug/ul
• Sequences: 137-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: mRNA processing

Gene Information

• Gene Name: CLK2 CDC-like kinase 2 [ Homo sapiens ]
• Official Symbol: CLK2
• Synonyms: CLK2; CDC-like kinase 2; hCLK2; MGC61500; dual specificity protein kinase CLK2; CLK kinase; OTTHUMP00000034063; OTTHUMP00000034064; THUMP00000034065; clk2; Dual specificity protein kinase CLK2; EC 2.7.12.1
• Gene ID: 1196
• mRNA Refseq: NM_003993
• Protein Refseq: NP_003984
• MIM: 602989
• UniProt ID: P49760
• Chromosome Location: 1q21
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity