Recombinant Human CLK2 Protein, GST-tagged

• Cat.No.: CLK2-1494H
• Product Overview: Human CLK2 full-length ORF ( AAH14067, 1 a.a. - 498 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.52 kDa
• AA Sequence: MPHPRRYHSSERGSRGSYREHYRSR KHKRRRSRSWSSSSDRTRRRRREDS YHVRSRSSYDDRSSDRRVYDRRYCG SYRRNDYSRDRGDAYYDTDYRHSYE YQRENSSYRSQRSSRRKHRRRRRRS RTFSRSSSHSSRRAKSVEDDAEGHL IYHVGDWLQERYEIVSTLGEGTFGR VVQCVDHRRGGARVALKIIKNVEKY KEAARLEINVLEKINEKDPDNKNLC VQMFDWFDYHGHMCISFELLGLSTF DFLKDNNYLPYPIHQVRHMAFQLCQ AVKFLHDNKLTHTDLKPENILFVNS DYELTYNLEKKRDERSVKSTAVRVV DFGSATFDHEHHSTIVSTRHYRAPE VILELGWSQPCDVWSIGCIIFEYYV GFTLFQTHDNREHLAMMERILGPIP SRMIRKTRKQKYFYRGRLDWDENTS AGRYVRENCKPLRRYLTSEAEEHHQ LFDLIESMLEYEPAKRLTLGEALQH PFFARLRAEPPNKLWDSSRDISR
• Applications: Kinase Assay enlarge
  Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLK2 CDC-like kinase 2 [ Homo sapiens ]
• Official Symbol: CLK2
• Synonyms: CLK2; CDC-like kinase 2; dual specificity protein kinase CLK2; clk2; CLK kinase; hCLK2; MGC61500
• Gene ID: 1196
• mRNA Refseq: NM_003993
• Protein Refseq: NP_003984
• MIM: 602989
• UniProt ID: P49760