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CLK4

  • Official Full Name

    CDC-like kinase 4

  • Overview

    The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
  • Synonyms

    CLK4; CDC-like kinase 4; dual specificity protein kinase CLK4; OTTMUSP00000005756; OTTMUSP00000005757; OTTMUSP00000041113; AI987988; C85119; CDC like kinase 4; DKFZp686A20267; Protein serine threonine kinase Clk4; RP23-9N7.1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLK4-1500H Active Recombinant Human CLK4 Protein, GST-tagged Insect Cell GST
Human CLK4-1501H Recombinant Human CLK4 Protein, GST-tagged Wheat Germ GST
Human CLK4-366HCL Recombinant Human CLK4 cell lysate N/A
Human CLK4-01H Recombinant Human CLK4 Protein, GST-tagged Insect Cell GST
Human CLK4-6858HF Active Recombinant Full Length Human CLK4 Protein, GST-tagged Insect (sf21) GST 1-481
Human CLK4-2206HF Recombinant Full Length Human CLK4 Protein, GST-tagged In Vitro Cell Free System GST 481 amino acids
Mouse CLK4-3588M Recombinant Mouse CLK4 Protein Mammalian Cell His
Mouse CLK4-1761M-B Recombinant Mouse CLK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse CLK4-1761M Recombinant Mouse CLK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLK4-913R Recombinant Rhesus monkey CLK4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLK4-738R Recombinant Rhesus Macaque CLK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLK4-738R-B Recombinant Rhesus Macaque CLK4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLK4 involved in several pathways and played different roles in them. We selected most pathways CLK4 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA processingHNRNPL;RNASET2B;ZFP346;TXNL4A;HNRNPABA;ADAM5;RPL36A-HNRNPH2;SFPQ;PRPF4BB

CLK4 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK4 itself. We selected most functions CLK4 had, and list some proteins which have the same functions with CLK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPKDCC;SGK1;CPS1;KCNJ11;ATP10A;QRSL1;ERBB4A;AK8;KIF1B
protein bindingPRDM10;CYSLTR1;C12orf40;ZNF18;IFITM3;ARHGAP24;STX4;DTX3L;MTMR6
protein serine/threonine kinase activityPRKCQ;SNRKA;RIOK3;CSNK1G2A;TAOK3;PAK7;ATM;ADCK5;SQSTM1
protein serine/threonine/tyrosine kinase activityAURKC;PRKCG;RPS6KA1;CLK1;TESK1;MAP2K1;TNK2;RPS6KB1;DYRK1AA
protein tyrosine kinase activityFGR;KITA;DYRK1A;SHC1;FYNA;PTK2;SRMS;FGFR1;PTK6B

CLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK4.

KPNA1; KRTAP10-7; KRTAP10-8; KRTAP10-9; SRPK1; UBL5; RNF181; RGMA; AHCYL2

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