clk4
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  • Official Full Name
  • CDC-like kinase 4
  • Background
  • The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
  • Synonyms
  • CLK4; CDC-like kinase 4; dual specificity protein kinase CLK4; OTTMUSP00000005756; OTTMUSP00000005757; OTTMUSP00000041113; AI987988; C85119; CDC like kinase 4; DKFZp686A20267; Protein serine threonine kinase Clk4; RP23-9N7.1
Cat.#:CLK4-1500HTag:GST
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human CLK4 Protein, GST-tagged
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Cat.#:CLK4-1501HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLK4 Protein, GST-tagged
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Cat.#:CLK4-3588MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLK4 Protein
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Cat.#:CLK4-913RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLK4 Protein, His-tagged
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Cat.#:CLK4-366HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CLK4 cell lysate
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Involved Pathway

CLK4 involved in several pathways and played different roles in them. We selected most pathways CLK4 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA processing
DHX15; PPM1G; WBP4; SRPK2; HNRNPA2B1; SPOP; CLASRP; CD2BP2; TXNL4A; SREK1

Protein Function

CLK4 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK4 itself. We selected most functions CLK4 had, and list some proteins which have the same functions with CLK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CSNK2A2A; PSMC5; Abca2; AK5L; TTLL11; PDPK1A; PRKX; NAT10; ATP1A1B; UCK2
Function protein binding
Related Protein PITPNC1; KIR2DL3; HADHB; BRD8; ITPR1; ATRNL1; MED30; B2M; ZKSCAN4; COPS6
Function protein serine/threonine kinase activity
Related Protein OBSCN; MAST2; BCKDK; SBK1; TGFBR1B; CSNK2A2; GAK; ICK; TAF1L; PDK3
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK2; CLK2; SGK1; AURKB; AKT1; PRKAA2; TTK; MAP2K1; AURKA; PRKCG
Function protein tyrosine kinase activity
Related Protein PTK7A; FYNA; TYRO3; EPHA7; IGF1R; KDR; TESK2; TEK; CSK; BTK

Interacting Protein

CLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK4.
KPNA1; KRTAP10-7; KRTAP10-8; KRTAP10-9; SRPK1; UBL5; RNF181; RGMA; AHCYL2