COQ2 Protein, coenzyme Q2 homolog, prenyltransferase (yeast)

COQ2

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COQ2

Official Full Name coenzyme Q2 homolog, prenyltransferase (yeast)
Background This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement.
Synonyms COQ2; coenzyme Q2 homolog, prenyltransferase (yeast); 4-hydroxybenzoate polyprenyltransferase, mitochondrial; 4 hydroxybenzoate polyprenyltransferase; CL640; FLJ26072; MGC91278; 2310002F18Rik; FLJ13014; hCOQ2; MGC124824; OTTMUSP00000032111; Para-hydroxybenzoate--polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; RGD1306722; COQ2 homolog; para-hydroxybenzoate-polyprenyltransferase, mitochondrial
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COQ2-1713H Recombinant Human COQ2 Protein, GST-tagged Wheat Germ GST
    Mouse COQ2-3790M Recombinant Mouse COQ2 Protein Mammalian Cell His
    Rat COQ2-1537R Recombinant Rat COQ2 Protein Mammalian Cell His
    Zebrafish COQ2-5589Z Recombinant Zebrafish COQ2 Mammalian Cell His

    COQ2 involved in several pathways and played different roles in them. We selected most pathways COQ2 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COQ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquinone and other terpenoid-quinone biosynthesis COQ2; HPDB; GGCX; HPD; TAT; COQ5; HPDA; VKORC1L1; COQ6; COQ7
    Metabolic pathways GLCEB; P4HA1B; NAGK; ALG9; AKR1B7; CYP2C55; AMY2A5; NMNAT2; C1GALT1; PLCD3

    COQ2 has several biochemical functions, for example, 4-hydroxybenzoate decaprenyltransferase activity, 4-hydroxybenzoate nonaprenyltransferase activity, prenyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COQ2 itself. We selected most functions COQ2 had, and list some proteins which have the same functions with COQ2. You can find most of the proteins on our site.

    Function Related Protein
    4-hydroxybenzoate decaprenyltransferase activity COQ2
    4-hydroxybenzoate nonaprenyltransferase activity COQ2
    prenyltransferase activity COQ2; UBIAD1; PTAR1; PGGT1B
    transferase activity ST3GAL5L; GLT25D2; KITA; GSTP2; UGT2B3; NTRK2B; GXYLT2; DNAJC3B; DCLK2; ELOVL4

    COQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COQ2.

    Lin, CH; Lin, HI; et al. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. NEUROBIOLOGY OF AGING 36:-(2015).
    Desbats, MA; Lunardi, G; et al. Genetic bases and clinical manifestations of coenzyme Q(10) (CoQ(10)) deficiency. JOURNAL OF INHERITED METABOLIC DISEASE 38:145-156(2015).

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