cox10
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  • Official Full Name
  • COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • Background
  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
  • Synonyms
  • COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; mitochondrial; 2410004F01Rik; AU042636; COX10_HUMAN; Cytochrome c oxidase assembly protein; Cytochrome c oxidase subunit X; Heme A farnesyltransferase; Heme O synthase; OTTMUSP00000006085; Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase, mitochondrial precursor; RP23-78H18.1; heme A: farnesyltransferase
Cat.#:COX10-1732HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COX10 Protein, GST-tagged
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Cat.#:COX10-980RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COX10 Protein, His-tagged
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Cat.#:COX10-2403CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COX10
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Cat.#:COX10-7606ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COX10
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Cat.#:COX10-387HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COX10 cell lysate
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Involved Pathway

COX10 involved in several pathways and played different roles in them. We selected most pathways COX10 participated on our site, such as Heme biosynthesis, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX10 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Heme biosynthesis
COX10; COX15; CPOX
Metabolic pathways
FUT1; AZIN2; DGKE; NDUFC2-KCTD14; SHMT1; POLR2J3; ADH7; DAO1; NOS3; GUSB
Metabolism
PIK3R6; LRPPRC; LOC100686744; UGT1B4; APOBB.1; CYP2AD2; CKM; YY2; CTHL; DDAH2
Metabolism of porphyrins
COX10; CPOX; UGT1B5; UGT1B2; UGT1B7; UGT1B4; UGT1B1; COX15; UGT1B3
Oxidative phosphorylation
COX7A2A; NDUFS2; ATP6AP2; NDUFA9A; ATP5F1; NDUFS5; ATP6V0A1A; UQCRC1; SDHC; NDUFV2
Porphyrin and chlorophyll metabolism
UGT1A1; UGT1AB; ALAD; UGT1A3; MMAB; HCCSA.1; HEPH; UGT1A6A; UGT2A1; UGT1A4

Protein Function

COX10 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, farnesyltranstransferase activity, protoheme IX farnesyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX10 itself. We selected most functions COX10 had, and list some proteins which have the same functions with COX10. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cytochrome-c oxidase activity
Related Protein COX15; COX10; NDUFA4
Function farnesyltranstransferase activity
Related Protein FNTB; COX10; GGPS1
Function protoheme IX farnesyltransferase activity
Related Protein UBIAD1; COX10