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Recombinant Human COX10 Protein, GST-tagged

Cat.No. : COX10-1732H
Product Overview : Human COX10 full-length ORF ( AAH06394, 1 a.a. - 443 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 74.36 kDa
AA Sequence : MAASPHTLSSRLLTGCVGGSVWYLE RRTIQDSPHKFLHLLRNVNKQWITF QHFSFLKRMYVTQLNRSHNQQVRPK PEPVASPFLEKTSSGQAKAEIYEMR PLSPPSLSLSRKPNEKELIELEPDS VIEDSIDVGKETKEEKRWKEMKLQV YDLPGILAQLSKIKLTALVVSTTAA GFALAPGPFDWPCFLLTSVGTGLAS CAANSINQFFEVPFDSNMNRTKNRP LVRGQISPLLAVSFATCCAVPGVAI LTLGVNPLTGALGLFNIFLYTCCYT PLKRISIANTWVGAVVGAIPPVMGW TAATGSLDAGAFLLGGILYSWQFPH FNALSWGLREDYSRGGYCMMSVTHP GLCRRVALRHCLALLVLSAAAPVLD ITTWTFPIMALPINAYISYLGFRFY VDADRRSSRRLFFCSLWHLPLLLLL MLTCKRPSGGGDAGPPPS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) [ Homo sapiens ]
Official Symbol : COX10
Synonyms : COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; heme O synthase; heme A: farnesyltransferase; cytochrome c oxidase subunit X; cytochrome c oxidase assembly protein;
Gene ID : 1352
mRNA Refseq : NM_001303
Protein Refseq : NP_001294
MIM : 602125
UniProt ID : Q12887

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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