Recombinant Human COX10 cell lysate
Cat.No. : | COX10-387HCL |
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Description : | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Tag : | Non |
Gene Name : | COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) [ Homo sapiens ] |
Official Symbol : | COX10 |
Synonyms : | COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; heme O synthase; heme A: farnesyltransferase; cytochrome c oxidase subunit X; cytochrome c oxidase assembly protein; |
Gene ID : | 1352 |
mRNA Refseq : | NM_001303 |
Protein Refseq : | NP_001294 |
MIM : | 602125 |
UniProt ID : | Q12887 |
Chromosome Location : | 17p12 |
Pathway : | Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Metabolic pathways, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem; Oxidative phosphorylation, conserved biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem; Porphyrin and chlorophyll metabolism, conserved biosystem; |
Function : | contributes_to cytochrome-c oxidase activity; farnesyltranstransferase activity; protoheme IX farnesyltransferase activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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