Recombinant Human COX10 cell lysate

• Cat.No.: COX10-387HCL

Specification

• Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) [ Homo sapiens ]
• Official Symbol: COX10
• Synonyms: COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; heme O synthase; heme A: farnesyltransferase; cytochrome c oxidase subunit X; cytochrome c oxidase assembly protein
• Gene ID: 1352
• mRNA Refseq: NM_001303
• Protein Refseq: NP_001294
• MIM: 602125
• UniProt ID: Q12887
• Chromosome Location: 17p12
• Pathway: Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Metabolic pathways, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem; Oxidative phosphorylation, conserved biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem; Porphyrin and chlorophyll metabolism, conserved biosystem
• Function: contributes_to cytochrome-c oxidase activity; farnesyltranstransferase activity; protoheme IX farnesyltransferase activity; transferase activity