cox15
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  • Official Full Name
  • COX15 homolog, cytochrome c oxidase assembly protein (yeast)
  • Background
  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.
  • Synonyms
  • COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog; COX15_HUMAN; cytochrome c oxidase subunit 15
Cat.#:COX15-1735HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COX15 Protein, GST-tagged
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Cat.#:COX15-2395HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COX15
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Cat.#:COX15-11486HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COX15, GST-tagged
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Cat.#:COX15-26362THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human COX15
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Cat.#:COX15-3808MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COX15 Protein
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Cat.#:COX15-3815CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COX15
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Cat.#:COX15-11422ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COX15
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Involved Pathway

COX15 involved in several pathways and played different roles in them. We selected most pathways COX15 participated on our site, such as Electron Transport Chain, Heme biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX15 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Electron Transport Chain
COX8A; COX6B1; COX5B; COX11; SURF1; ATP5L; COX15; COX6A1; COX6A2; SLC25A14
Heme biosynthesis
CPOX; COX10; COX15
Metabolic pathways
QDPRA; GCDHB; PANK1; DHODH; mt-Atp8; AKR1A1B; GOT2A; PGAM2; PIGYL; HSD11B1
Metabolism
INSIG1; SLC25A15B; SLC25A21; PPM1L; CETP; NUDT15; ACOT11A; PDK2; SLC25A15; GPHNA
Metabolism of porphyrins
UGT1B3; UGT1B7; COX10; COX15; UGT1B5; UGT1B4; UGT1B1; UGT1B2; CPOX
Oxidative phosphorylation
SDHA; NDUFB6; ATP6V1B1; ATP5J2; ATP6V0A1A; NDUFS8; NDUFA11; ATP6V0A1B; ATP5A1; COX7B
Porphyrin and chlorophyll metabolism
UGT1A6B; BLVRA; COX10; ALAS1; UGT1A6A; HCCS; HMOX1A; MMAB; FECH; UGT2A1

Protein Function

COX15 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, cytochrome-c oxidase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by COX15 itself. We selected most functions COX15 had, and list some proteins which have the same functions with COX15. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cytochrome-c oxidase activity
Related Protein COX10; COX15; NDUFA4
Function cytochrome-c oxidase activity
Related Protein COX15; COX6B2; COX7A2; COX5B2; COX6A1; COX7B; COX7B2; COX7A2L; COX6B1; COX5AA
Function oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Related Protein COX15; CYB5R4
Function oxidoreductase activity, acting on the CH-CH group of donors
Related Protein TECRL2B; TECRL; LBR; SRD5A2B; DPYDB; TECRB; TECR; TM7SF2; GCDHA; PPP1R2

Interacting Protein

COX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX15.
CLN3; SLC25A3; SLC25A11; TIMM50; SLC25A24; MRPL14; SFXN4; TMEM65; SFXN1; SLC25A19; COA3