Recombinant Human COX15, GST-tagged

• Cat.No.: COX15-11486H
• Product Overview: Recombinant Human COX15 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-410a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) [ Homo sapiens ]
• Official Symbol: COX15
• Synonyms: COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
• Gene ID: 1355
• mRNA Refseq: NM_004376
• Protein Refseq: NP_004367
• MIM: 603646
• UniProt ID: Q7KZN9
• Chromosome Location: 10q24
• Pathway: Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem; Oxidative phosphorylation, conserved biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem
• Function: catalytic activity; contributes_to cytochrome-c oxidase activity; cytochrome-c oxidase activity; oxidoreductase activity, acting on the CH-CH group of donors