Recombinant Human COX15

Cat.No. : COX15-26362TH
Product Overview : Recombinant fragment of Human COX15 with an N terminal proprietary tag; Predicted MWt 32.34 kDa.
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Description : Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.
Protein length : 61 amino acids
Molecular Weight : 32.340kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : LTESGLSMVDWHLIKEMKPPTSQEE WEAEFQRYQQFPEFKILNHDMTLTE FKFIWYMEYSH
Sequence Similarities : Belongs to the COX15/CtaA family.
Gene Name : COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) [ Homo sapiens ]
Official Symbol : COX15
Synonyms : COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog;
Gene ID : 1355
mRNA Refseq : NM_004376
Protein Refseq : NP_004367
MIM : 603646
Uniprot ID : Q7KZN9
Chromosome Location : 10q24
Pathway : Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem;
Function : catalytic activity; contributes_to cytochrome-c oxidase activity; cytochrome-c oxidase activity; oxidoreductase activity, acting on the CH-CH group of donors;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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