cox4i2
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  • Official Full Name
  • cytochrome c oxidase subunit IV isoform 2 (lung)
  • Background
  • Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
  • Synonyms
  • COX4I2; cytochrome c oxidase subunit IV isoform 2 (lung); COX4L2, cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX4 2; COX4B; COXIV 2; cytochrome c oxidase subunit IV like 2; dJ857M17.2; COX IV-2; cy
Cat.#:COX4I2-1744HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COX4I2 Protein, GST-tagged
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Cat.#:COX4I2-1551RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COX4I2 Protein
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Cat.#:COX4I2-988RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COX4I2 Protein, His-tagged
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Cat.#:COX4I2-11059ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COX4I2
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Cat.#:COX4I2-388HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human COX4I2 cell lysate
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Involved Pathway

COX4I2 involved in several pathways and played different roles in them. We selected most pathways COX4I2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
NDUFS4; UQCRB; COX7A1; ATP6V1C1B; PPA2; ATP6V0A2B; ATP6V0E; ATP5G3B; ATP6V1C1A; NDUFB8
Metabolic pathways
FBP1; ST3GAL3; GGT6; ADOB; PRDX6; MAN1C1; ASAH1B; ATP6V1F; ST6GALNAC5; CELL
Cardiac muscle contraction
CACNG6A; CACNG7A; TMEM8C; TNNC1A; CACNB1; ATP1A1B; COX7A2L; CACNG6; CACNB4A; TNNI3
Non-alcoholic fatty liver disease (NAFLD)
NDUFA13; COX6A2; AKT1; UQCR10; NDUFS4; BID; Fasl; XBP1; EIF2AK3; PIK3R3
Alzheimers disease
NDUFC1; NDUFB3; NDUFB9; CAPN1; CAPN2; CALML5; COX6B2; COX7A1; NDUFB10; NDUFB11
Parkinsons disease
TH; ATP5A1; PRKACB; NDUFB10; UQCRQ; ATP5B; NDUFA4; APAF1; GPR37; NDUFA8
Huntingtons disease
mt-Atp8; ATP5B; APAF1; UCP1; SIN3A; EP300; DCTN2; Atp5g2; PPARG; NDUFS8

Protein Function

COX4I2 has several biochemical functions, for example, cytoskeletal adaptor activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I2 itself. We selected most functions COX4I2 had, and list some proteins which have the same functions with COX4I2. You can find most of the proteins on our site.
Function
Related Protein
Function cytoskeletal adaptor activity
Related Protein BICD1; NCK2; BAIAP2L1A; ABI2; BAIAP2L2B; BAIAP2L1B; SORBS2; BAIAP2A; BAIAP2L1; BAIAP2L2
Function metal ion binding
Related Protein CFI; VSNL1A; PLEKHF2; MYLIPB; ZBTB37; ZFP259; TRIM43A; BRD1B; DNAJA4; ALKBH6
Function poly(A) RNA binding
Related Protein HSPD1; ZFP598; RPS24; PARP1; RPS15; GTPBP10; YTHDF3; RRP1; DCN; RPL31
Function protein binding
Related Protein HDLBP; USH1C; C7orf49; LILRA4; IL32; POLD3; MYCBP; C19orf44; AXL; PDZK1
Function protein domain specific binding
Related Protein WNT3; STX18; TFDP1; ETV6; MYO7A; IKBKG; ODF1; MPP7; CASP2; HIST4H4
Function structural constituent of cytoskeleton
Related Protein PLS1; TUBE1; TUBA8L4; ARPC4; NDC80; BKJ; TUBA8L2; BFSP1; ACTR3; TUBB2B
Function structural constituent of muscle
Related Protein PDLIM3; ACTN3; MYLPF; MYL6; MYL5; MYBPC3; ASPH; MYL3; ACTN2; ANKRD2