COX4I2

  • Official Full Name

    cytochrome c oxidase subunit IV isoform 2 (lung)

  • Overview

    Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.

  • Synonyms

    COX4I2;cytochrome c oxidase subunit IV isoform 2 (lung);COX4L2, cytochrome c oxidase subunit IV isoform 2;cytochrome c oxidase subunit 4 isoform 2, mitochondrial;COX4 2;COX4B;COXIV 2;cytochrome c oxidase subunit IV like 2;dJ857M17.2;COX IV-2;cy

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Rhesus macaque
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
COX4I2-11059Z Recombinant Zebrafish COX4I2 Mammalian Cells Zebrafish His
COX4I2-1551R Recombinant Rat COX4I2 Protein Mammalian Cells Rat His
COX4I2-1744H Recombinant Human COX4I2 Protein, GST-tagged Wheat Germ Human GST
COX4I2-988R Recombinant Rhesus monkey COX4I2 Protein, His-tagged Mammalian Cells Rhesus macaque His
COX4I2-388HCL Recombinant Human COX4I2 cell lysate Human Non
COX4I2-1208R Recombinant Rat COX4I2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
COX4I2-1208R-B Recombinant Rat COX4I2 Protein Pre-coupled Magnetic Beads HEK293 Rat
COX4I2-2004HF Recombinant Full Length Human COX4I2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 171 amino acids
COX4I2-813R Recombinant Rhesus Macaque COX4I2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
COX4I2-813R-B Recombinant Rhesus Macaque COX4I2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    COX4I2 involved in several pathways and played different roles in them. We selected most pathways COX4I2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-alcoholic fatty liver disease (NAFLD) NDUFS4,RXRA,TGFB1,COX7A1,SREBF1,NDUFB1,NDUFV1,CDC42,IL1A,NDUFA9
    Cardiac muscle contraction COX7A2L,TPM1,CACNG1,ATP2A2,ATP1B3A,MYH15,ATP1A3A,CACNA1DA,CACNG8,COX6B2
    Metabolic pathways ALDH1A1,PLD2,ACACA,AK7B,NME3,ADPGK,ALPI,B3GNT5,NDUFS8A,UQCRC2B
    Huntingtons disease TFAM,NDUFS3,ATP5E,POLR2H,PPARGC1A,GNAQ,BBC3,CREB3L1,TBPL1,SLC25A4
    Parkinsons disease NDUFAB1,SLC25A5,SLC6A3,VDAC1,UBE2G1,SDHC,UBE2J1,ATP5O,UBE1Y1,NDUFA2
    Oxidative phosphorylation UQCRH,ATP6AP2,COX10,SDHDA,UQCRC2,ATP5G3B,ATP6V1E1B,Atp5g2,ATP5J2,ATP6V0E
    Alzheimers disease GRIN1,APOE,ATP5D,NDUFB5,SDHA,ATP5B,NDUFV3,PPP3CA,BAD,NDUFB9

    Protein Function

    COX4I2 has several biochemical functions, for example, cytoskeletal adaptor activity,metal ion binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I2 itself. We selected most functions COX4I2 had, and list some proteins which have the same functions with COX4I2. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding STRAP,WIBG,LTA4H,SLIRP,NOC2L,EIF3C,NONO,HRSP12,MKRN2,NKRF
    structural constituent of cytoskeleton SORBS2,TUBA1L2,LOR,EPB41,TUBA1C,TUBB2B,KRT17,ACTL7B,TUBA8,TUBA1L
    metal ion binding ENO2,ZNF221,ZC3H11A,NIM1,TDO2B,NR6A1A,ZNF394,ARAP1,ZFP458,PPARAB
    cytoskeletal adaptor activity BAIAP2L2,BAIAP2A,BIN3,NCK2,ANK1,BICD1,GAS2L2,GAS2L1,NCK1,BAIAP2L1B
    protein binding COL3A1,TYRP1,GGN,KIAA1958,L3MBTL4,DCUN1D5,PROC,TP73,C6orf211,Pilrb1
    protein domain specific binding MTOR,HPCAL4,TRP63,MITD1,ACTN2,HIST1H4L,EZR,PRKAR2B,RAB27A,YWHAQB
    structural constituent of muscle TPM1,CAPN3,MYL1,TPM2,MYH11,SMTN,ACTN3,NEXN,MYL9,DAG1

    Interacting Protein

    COX4I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I2.

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