cplx1
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  • Official Full Name
  • complexin 1
  • Background
  • Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis.These proteins bind syntaxin, part of the SNAP receptor.The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.
  • Synonyms
  • CPLX1; complexin 1; complexin-1; CPX I; 921-S; Complexin I; CPLX1_HUMAN; CPX-I; CPX1; Synaphin 2; Synaphin-2
Cat.#:CPLX1-1785HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CPLX1 Protein, GST-tagged
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Cat.#:CPLX1-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CPLX1 Protein, His-tagged
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Cat.#:CPLX1-11519HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CPLX1, GST-tagged
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Cat.#:CPLX1-27587THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CPLX1, His-tagged
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Cat.#:CPLX1-27588THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CPLX1, His-tagged
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Cat.#:CPLX1-305HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Complexin 1, His-tagged
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Cat.#:CPLX1-3840MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CPLX1 Protein
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Cat.#:CPLX1-1566RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CPLX1 Protein
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Cat.#:CPLX1-419CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CPLX1 Protein, His-tagged
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Cat.#:CPLX1-1003RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CPLX1 Protein, His-tagged
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Cat.#:CPLX1-7313HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CPLX1 293 Cell Lysate
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Involved Pathway

CPLX1 involved in several pathways and played different roles in them. We selected most pathways CPLX1 participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, GABA synthesis, release, reuptake and degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPLX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acetylcholine Neurotransmitter Release Cycle
SNAP25B; STXBP1A; RERG; CPLX1; UNC13B; PPFIA2; CPLX2L; SLC18A3A; SYT1A; SNAP25A
Dopamine Neurotransmitter Release Cycle
PPFIA2; PPFIA1; LIN7B; Apba1; LIN7C; RERG; CCDC167; SYN3; PPFIA4; UNC13B
GABA synthesis, release, reuptake and degradation
SYT1A; SLC6A1B; SLC6A1A; SNAP25B; SNAP25A; RAB3AA; SLC6A12; SLC6A11; STXBP1A; CPLX1
Glutamate Neurotransmitter Release Cycle
ARL6IP5B; SNAP25A; STXBP1A; RAB3AA; SLC1A7A; PPFIA2; CPLX1; SLC17A7A; ARL6IP5; ARL6IP5A
Neuronal System
KCNH2A; KCNA6; KCNA2; KCND1; KCNF1A; KCNAB1; KCNK2; KCNV2; KCNA10; PPFIA4
Neurotransmitter Release Cycle
SLC17A7A; LIN7C; SLC6A11; SYT1A; STXBP1A; RAB3AB; LIN7B; SLC1A7B; PPFIA4; RERG
Norepinephrine Neurotransmitter Release Cycle
CPLX2L; RAB3AB; RERG; PPFIA1; PPFIA4; STXBP1A; BZRAP1; RAB3AA; CPLX1; SNAP25A
Serotonin Neurotransmitter Release Cycle
SYN1; RERG; SYN2; PPFIA2; PPFIA4; SYN3; PPFIA1; CPLX1

Protein Function

CPLX1 has several biochemical functions, for example, neurotransmitter transporter activity, syntaxin-1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPLX1 itself. We selected most functions CPLX1 had, and list some proteins which have the same functions with CPLX1. You can find most of the proteins on our site.
Function
Related Protein
Function neurotransmitter transporter activity
Related Protein SLC6A15; GABRQ; CPLX3; CPLX1
Function syntaxin-1 binding
Related Protein STXBP3A; STXBP2; SNAP25B; SNAP25; GOLSYN; STXBP1; CCDC167; STXBP3; SNAP25A; CPLX1

Interacting Protein

CPLX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPLX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPLX1.
RXRB; pi3p; IQCB1

CPLX1 Related Articles

Stenovec, M; Goncalves, PP; et al. Peptide Hormone Release Monitored From Single Vesicles in "Membrane Lawns" of Differentiated Male Pituitary Cells: SNAREs and Fusion Pore Widening. ENDOCRINOLOGY 154:1235-1246(2013).
Keino, H; Watanabe, T; et al. Effect of Infliximab on Gene Expression Profiling in Behcet's Disease. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:7681-7686(2011).