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CSK

  • Official Full Name

    c-src tyrosine kinase

  • Overview

    Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds
  • Synonyms

    CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSK-170H Active Recombinant Human C-src Tyrosine Kinase E.coli N/A
Human CSK-1394H Active Recombinant Human CSK, GST-tagged Sf9 Insect Cell GST Full length
Human CSK-61HFL Active Recombinant Full Length Human CSK Protein, N-GST-tagged E. coli GST Full Length
Human CSK-657HFL Active Recombinant Full Length Human CSK Protein, C-Flag-tagged Mammalian cells Flag
Human CSK-388H Recombinant Human C-Src Tyrosine Kinase, GST-tagged Sf9 Insect Cell GST
Human CSK-26133TH Recombinant Human CSK, His-tagged E.coli His 450 amino acids
Human CSK-27H Recombinant Human c-src tyrosine kinase Sf9 Insect Cell N/A
Human CSK-288H Recombinant Human C-src Tyrosine Kinase, GST-tagged, Active Sf9 Insect Cell GST
Human CSK-619H Recombinant Human c-src tyrosine kinase, His-tagged E.coli His
Human CSK-1979H Recombinant Human CSK Protein, GST-tagged Wheat Germ GST
Human CSK-628HCL Recombinant Human CSK cell lysate Insect Cell N/A
Human CSK-1388HF Active Recombinant Full Length Human CSK Protein, GST-tagged Insect (sf21) GST 1-450(end)
Human CSK-576H Recombinant Human CSK Protein, His-tagged E.coli His Leu243~Glu438
Human CSK-3345H Recombinant Human CSK Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSK-342H Active Recombinant Human CSK Protein, GST-tagged Insect Cell GST Met 1-Leu 450
Human CSK-0472H Recombinant Human CSK Protein (Full Length), Tag Free Baculovirus-Insect cells Tag Free Full Length
Human CSK-0764H Recombinant Human CSK Protein (M1-L450), Tag Free Insect Cell No tag M1-L450
Human CSK-6272H Recombinant Human CSK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSK-27872TH Native Human CSK Insect Cell N/A
Human CSK-2181HF Recombinant Full Length Human CSK Protein, GST-tagged In Vitro Cell Free System GST 450 amino acids
Human CSK-672H Recombinant Human CSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CSK-0765H Recombinant Human CSK Protein (M1-L450), GST tagged Insect Cell GST M1-L450
Human CSK-672H-B Recombinant Human CSK Protein Pre-coupled Magnetic Beads HEK293
Mouse CSK-925M Active Recombinant Mouse CSK Protein, GST & His-tagged Insect Cell GST/His
Mouse CSK-436M Recombinant Mouse Csk, Gly & Pro tagged Insect Cell His
Mouse CSK-001MCL Recombinant Mouse CSK cell lysate Insect Cell N/A
Mouse CSK-3222M Recombinant Mouse CSK protein(Met1-Leu450) Insect Cells N/A Met1-Leu450
Mouse Csk-942M Recombinant Mouse Csk Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CSK-1628R Recombinant Rat CSK Protein Mammalian Cell His
Rat CSK-1286R-B Recombinant Rat CSK Protein Pre-coupled Magnetic Beads HEK293
Rat CSK-1286R Recombinant Rat CSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CSK-1057R Recombinant Rhesus monkey CSK Protein, His-tagged Mammalian Cell His
Rhesus Macaque CSK-882R-B Recombinant Rhesus Macaque CSK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CSK-882R Recombinant Rhesus Macaque CSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CSK-4794Z Recombinant Zebrafish CSK Mammalian Cell His
Chicken CSK-6976C Recombinant Chicken CSK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CSK Related Articles

CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationFGF18B;CSK;CSF2RB;JAK1;FRS2;SPRED1;SPTBN1;NRG4;WDR83
Adaptive Immune SystemFAM49BA;KLRF1;RNF14;DTX3L;ERAP2;STUB1;UBE2V1;ACTR1A;MOV10
Axon guidanceRHOAE;EFNA5;RHOGA;LIMK1;ITSN1;KCNQ3;SIAH2;SEMA5B;CSF2RB
B Cell Receptor Signaling PathwayPILRB;PIK3CA;MAP4K1;PRKCB;NRAS;CD22;PDPK1A;IFITM1;ITPR2
BCR signaling pathwayIBTK;NETO2;MAP4K1;CSK;POU2F2;PAG1;DOK1;CSNK2A1;MALT1
CXCR4-mediated signaling eventsCRK;CFL1;GNB2L1;DNM1;CSK;ARR3;JAK2;ADRBK1;PAG1
Costimulation by the CD28 familyTHEM4;HLA-DQB2;CSK;BTLA;PDPK1A;MAP3K8;MAPKAP1;CTLA4
Cytokine Signaling in Immune systemMARK3;FGF10B;NEFLB;CASPB;GHRB;EDA;KBTBD7;TRIM8;HERC5

CSK has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYH6;PAK2A;DDX39AA;MAP3K3;PI4K2A;ITPKB;TESK2;PFKMB;PAPSS1
identical protein bindingGRB2;ERN1;SNX1;HAPLN2;MPZL2B;PRDX3;ATXN10;RAD52;RELA
metal ion bindingB3GAT1;SALL3B;CDK5RAP1;PAPD7;CASZ1;CYB561A3A;ZMYND15;ZFP35;LATS2
non-membrane spanning protein tyrosine kinase activityJAK3;PTK6B;FER;TYK2;Fert2;FYNA;FYNB;RIPK2;PTK6
proline-rich region bindingGHR;CYLD;FAM59A;PRPF40A;BAIAP2;NEDD4;GAREM;CCND1;ABL1
protein C-terminus bindingPFKM;SHANK1;NCF2;FOXN3;AGO2;YWHAQ;HIC2;TOP2B;ZBTB16
protein bindingPGM1;SF3A3;NGF;ASNA1;RBBP5;BAD;SYTL2;CBFA2T3;ASXL1
protein kinase A catalytic subunit bindingPRKAR2A;SOX9;PRKAR1A;GSK3B;CSK;PRKAR2B;PRKAR1B;GSK3A;RYR2
protein phosphatase bindingANAPC4;LCK;PIK3R2;STAT6;PPME1;PPP1R3C;PIK3R1;CDH2;KAT2A
protein tyrosine kinase activityAXL;FYNA;EPHA4A;MAP2K2;CLK4;PTK2B;LTK;ALK;BLK
receptor bindingWNT4A;IDH1;ARRB2;CXADR;HSPA1A;FGF6B;NUDT7;CAPRIN2;CROT

CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.

SRC; PTPRC; EGFR; IGF1R; G3BP1

Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).
Dokmanovic, M; Wu, Y; et al. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. CANCER BIOLOGY & THERAPY 15:1029-1041(2014).
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