csk
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  • Official Full Name
  • c-src tyrosine kinase
  • Background
  • Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds
  • Synonyms
  • CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393
Cat.#:CSK-342HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSK Protein, GST-tagged
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Cat.#:CSK-1979HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CSK Protein, GST-tagged
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Cat.#:CSK-3345HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSK Protein, MYC/DDK-tagged
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Cat.#:CSK-576HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSK Protein, His-tagged
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Cat.#:CSK-27HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human c-src tyrosine kinase
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Cat.#:CSK-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C-src Tyrosine Kinase
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Cat.#:CSK-26133THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSK, His-tagged
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Cat.#:CSK-288HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human C-src Tyrosine Kinase, GST-tagged, Active
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Cat.#:CSK-619HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human c-src tyrosine kinase, His-tagged
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Cat.#:CSK-436MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Csk, Gly & Pro tagged
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Cat.#:CSK-925MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CSK Protein, GST & His-tagged
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Cat.#:CSK-1628RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CSK Protein
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Cat.#:CSK-1057RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CSK Protein, His-tagged
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Cat.#:CSK-6976CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CSK
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Cat.#:CSK-4794ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CSK
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Cat.#:CSK-388HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human C-Src Tyrosine Kinase, GST-tagged
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Cat.#:CSK-1394HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CSK (Active), GST-tagged
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Cat.#:CSK-27872THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameNative Human CSK
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Cat.#:CSK-628HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSK cell lysate
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Cat.#:CSK-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CSK cell lysate
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Involved Pathway

CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
SPRED2; CSF2RB; CSF2; NRG4; PSMD9; DUSP2; PEA15; PTPRA; SPTBN2; LAMTOR2
Adaptive Immune System
RACGAP1; RNF138; DYNC1I1; CDKN1A; AP2B1; AP2M1; TRIM39; THEM4; AMICA1; KIF3C
Axon guidance
CLASP1; EPHA6; RASGRP4; PAK7; NRG3; CFL2; RHOB; SPRED3; NTNG1; EFNA5
B Cell Receptor Signaling Pathway
LAT2; PPP3R2; PDPK1A; NFKBIA; HDAC5; BLNK; NFATC2; IFITM1; SLA2; NEDD9
BCR signaling pathway
DOK1; PAG1; NETO2; IBTK; POU2F2; MAP4K1; CSNK2A1; MALT1; CSK
CXCR4-mediated signaling events
GNA13; ADRBK1; CSK; CFL1; GNB2L1; DNM1; BLK; ARR3; PAG1; CRK
Costimulation by the CD28 family
MAP3K8; MAPKAP1; CSK; PDPK1A; THEM4; BTLA; CTLA4; HLA-DQB2
Cytokine Signaling in Immune system
IRF2; CASPB; IFIT8; GBP6; TRIM62; PAQR3A; UBE2V1; PELI1; HLA-DQB2; IFITM2

Protein Function

CSK has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYLK3; ATAD1B; ATP2A3; EPHA10; PRKCD; KIF15; ENTPD1; TLK2; MAP3K1; ACVR1
Function identical protein binding
Related Protein CLDN6; FRS3; SIRT1; EGFR; APPL1; PAFAH1B3; INHBA; C1QTNF9; SNCAIP; CD247
Function metal ion binding
Related Protein TRIM71; TRIM55B; ACVR1B; ALKBH6; THAP8; SKINT8; HMOX2A; RTEL1; KDM6A; SNAI1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein ITK; TXK; FYNA; FER; BMX; PTK2BB; PTK2AB; EIF2AK2; TNK1; SRMS
Function proline-rich region binding
Related Protein ABL1; CSK; ITSN1; FAM59A; CYLD; YAP1; CCND1; APBB1; GHR; PRPF40A
Function protein C-terminus binding
Related Protein BCL10; NPAT; PDZD11; CTBP1; NCL; AGO2; CLIC6; SIAH1; DLG4; CAV3
Function protein binding
Related Protein FXYD6; QARS; CSTF3; UBE3A; BAG5; LTA4H; ADAP1; KCNJ5; CCT4; PLD1
Function protein kinase A catalytic subunit binding
Related Protein CSK; PRKAR1A; SOX9; GSK3B; PRKAR1B; PRKAR2B; GSK3A; PKIA; EZR; KCNQ1
Function protein phosphatase binding
Related Protein TRAF3; DRD1; JAK1; ANAPC4; VCP; SHOC2; JUP; CSF1R; RPA2; JAK3
Function protein tyrosine kinase activity
Related Protein EPHA4A; MAP3K11; HCK; ROS1; JAK2B; MUSK; ALK; JAK1; MAP2K3; DSTYK
Function receptor binding
Related Protein PLA2G1B; MIF; TMED1; NXPH3; CXADR; CD2; Itga10&Itgb1; PIPOX; PTK2AB; EPB49

Interacting Protein

CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.
SRC; PTPRC; EGFR; IGF1R; G3BP1

CSK Related Articles

Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).
Dokmanovic, M; Wu, Y; et al. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. CANCER BIOLOGY & THERAPY 15:1029-1041(2014).