Recombinant Human C-Src Tyrosine Kinase, GST-tagged

• Cat.No.: CSK-388H
• Product Overview: Recombinant humanCSK containing amino acids M1-L450, N-terminally fused to GST-HIS6-Thrombincleavage site.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-450 a.a.
• Description: C-src tyrosinekinase, also known as CSK, is a human protein and gene. It includes an SH2domain, an SH3 domain, and a tyrosine kinase domain. This proteinspecifically phosphorylates Tyr-504 residue on human leukocyte-specificprotein tyrosine kinase, which acts as a negative regulatory site. It mayalso act on the LYN and FYN kinases.
• Form: Liquid in 50 mMTris-HCl, pH 8.0 + 100 mM NaCl + 5 mM DTT + 15 mM reduced glutathione + 20%glycerol.
• Molecular Weight: 80.2 kDa
• Concentration: 0.722 mg/ml
• OfficialSymbol: CSK

Gene Information

• Gene Name: CSK c-src tyrosine kinase [ Homosapiens ]
• Synonyms: CSK; c-src tyrosinekinase; MGC117393; tyrosine-protein kinase CSK; C-Src kinase; OTTHUMP00000183471;protein-tyrosine kinase CYL; EC 2.7.10; EC 2.7.10.2
• Gene ID: 1445
• mRNA Refseq: NM_004383
• Protein Refseq: NP_004374
• MIM: 124095
• UniProt ID: P41240
• Chromosome Location: 15q24.1
• Pathway: Adaptive ImmuneSystem; B Cell Receptor Signaling Pathway; BCR signaling pathway;CXCR4-mediated signaling events; Costimulation by the CD28 family; EGFR1Signaling Pathway; Epithelial cell signaling in Helicobacter pyloriinfection; GAB1 signalosome; Hemostasis; Integrin cell surface interactions;PD-1 signaling; Platelet activation, signaling and aggregation; SignalTransduction; Signaling events mediated by PTP1B; TCR signaling in naive CD4+T cells
• Function: ATP binding;non-membrane spanning protein tyrosine kinase activity; nucleotide binding;proline-rich region binding; protein C-terminus binding; protein binding;protein phosphatase binding; protein tyrosine kinase activity; proteintyrosine phosphatase activity