CSTB Protein, cystatin B (stefin B)


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Official Full Name cystatin B (stefin B)
Background The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Synonyms CSTB; cystatin B (stefin B); EPM1, STFB; cystatin-B; CST6; PME; CPI-B; liver thiol proteinase inhibitor; ULD; EPM1; STFB; EPM1A
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CSTB-11649H Recombinant Human CSTB, GST-tagged E.coli GST
    Human CSTB-2038H Recombinant Human CSTB Protein, GST-tagged Wheat Germ GST
    Human CSTB-204H Recombinant Human CSTB protein, His-tagged E.coli His
    Human CSTB-299H Recombinant Human Cystatin B (Stefin B), His-tagged E.coli His
    Human CSTB-31464TH Recombinant Human CSTB, His-tagged E.coli His
    Human CSTB-3837H Recombinant Human CSTB, His tagged E.coli His
    Human Cstb-4002M Recombinant Mouse Cystatin B, His-tagged Mouse His
    Human CSTB-7224HCL Recombinant Human CSTB 293 Cell Lysate HEK293 N/A
    Mouse Cstb-1660M Recombinant Mouse Cstb protein, His-tagged E.coli His
    Mouse CSTB-4003M Recombinant Mouse CSTB Protein Mammalian Cell His
    Rat CSTB-1646R Recombinant Rat CSTB Protein Mammalian Cell His
    Rat Cstb-1661R Recombinant Rat Cstb protein, His-tagged E.coli His
    Rhesus Macaque CSTB-1070R Recombinant Rhesus monkey CSTB Protein, His-tagged Mammalian Cell His
    Chicken CSTB-4197C Recombinant Chicken CSTB Mammalian Cell His
    Cattle CSTB-1659C Recombinant Cattle CSTB protein, His-tagged E.coli His

    CSTB involved in several pathways and played different roles in them. We selected most pathways CSTB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CSTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    CSTB has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSTB itself. We selected most functions CSTB had, and list some proteins which have the same functions with CSTB. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity BIRC7; CST3; NAIP1; CST5; CST9; CST4; STFA2; NGP; BIRC5B; CST8
    endopeptidase inhibitor activity UCHL5; LPA; Hc; C3; AHSG; SERPINA1E; C4A; Serpina1b; Cstb; TFPI
    peptidase inhibitor activity NGP; COL7A1; SERPINB12; NAIP1; A2ML1; KAL1B; COL28A1; WFDC18; Serpina1b; PTTG1
    poly(A) RNA binding PPIG; HSD17B10; RBM28; KIF1C; RBM25; LSM6; SRSF7; XPO5; SRSF9; MYEF2
    protease binding INS2; INS1; FADD; SERPINB6; KIT; XBP1; POLG; SERPINC1; RYR1; INS

    CSTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSTB here. Most of them are supplied by our site. Hope this information will be useful for your research of CSTB.

    Ywhae; Ywhah; Hsd3b4; Pgls; Hsd3b7

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