cul3
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  • Official Full Name
  • cullin 3
  • Background
  • CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division.
  • Synonyms
  • CUL3; cullin 3; cullin-3; CUL-3; OTTHUMP00000164219; OTTHUMP00000203839; OTTHUMP00000203840
Cat.#:CUL3-149HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CUL3/Rbx1 Protein, GST-tagged
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Cat.#:CUL3-148HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CUL3/RBX1
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Cat.#:CUL3-321HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CUL3 protein, MYC/DDK-tagged
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Cat.#:CUL3-322HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CUL3 protein, GST-tagged
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Cat.#:CUL3-4077MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cul3 protein, His-tagged
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Cat.#:CUL3-1097RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CUL3 Protein, His-tagged
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Cat.#:CUL3-7183HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CUL3 293 Cell Lysate
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Involved Pathway

CUL3 involved in several pathways and played different roles in them. We selected most pathways CUL3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
UBE2QL1; CDC23; CUL1B; MGRN1B; UBE2S; DET1; TRAF6; UBE2E2; UBE2M; UBE2H

Protein Function

CUL3 has several biochemical functions, for example, POZ domain binding, cyclin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL3 itself. We selected most functions CUL3 had, and list some proteins which have the same functions with CUL3. You can find most of the proteins on our site.
Function
Related Protein
Function POZ domain binding
Related Protein KLHL17; Trl; CUL3
Function cyclin binding
Related Protein CDK12; INCA1; PFTK1; CDK4; USP2; PTCH1; CUL3; CDKN1A; CDK13; CDK2
Function protein binding
Related Protein HYLS1; NUDT16L1; SYMPK; PDIA6; GJA4; FAM124A; ROS1; WFIKKN1; ZBTB25; RFPL3
Function protein heterodimerization activity
Related Protein TRP53; CEBPG; KCNA3; TAF13; HIST1H4F; JAM2A; PPP3CB; BCL2A1; HIST1H3F; NFE2L2A
Function protein homodimerization activity
Related Protein NCR3; B4GALT1; PEX11B; IL6ST; DMBX1; ACTN1; Defa-rs7; DPP4; APOBEC3G; CARD8
Function contributes_to ubiquitin protein ligase activity
Related Protein FBXL3A; FBXL5; MED11; FBXL14B; KDM2BA; CUL4A; CUL2; MED12; CUL4B; FBXL20
Function ubiquitin protein ligase binding
Related Protein POLR2A; TRAF2; GGN; TRIB1; SPOP; BECN1; PRKAR2A; YWHAZ; CXCR4; RBX1
Function contributes_to ubiquitin-protein transferase activity
Related Protein KLHL4; KLHL40A; ERCC8; KLHL1; TCEB3C; KLHL24A; KBTBD13; DTL; TCEB1B; BCOR

Interacting Protein

CUL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL3.
CASP8; SPOP; KLHL2; TNFAIP1; KLHL12; FLJ13057

CUL3 Related Articles

Zuhlke, KA; Johnson, AM; et al. Identification of a Novel Germline SPOP Mutation in a Family With Hereditary Prostate Cancer. PROSTATE 74:983-990(2014).
Bitar, MS; Liu, CL; et al. Decline in DJ-1 and Decreased Nuclear Translocation of Nrf2 in Fuchs Endothelial Corneal Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:5806-5813(2012).