| Description : |
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
88.9 kDa |
| AA Sequence : |
MSNLSKGTGSRKDTKMRIRAFPMTM DEKYVNSIWDLLKNAIQEIQRKNNS GLSFEELYRNAYTMVLHKHGEKLYT GLREVVTEHLINKVREDVLNSLNNN FLQTLNQAWNDHQTAMVMIRDILMY MDRVYVQQNNVENVYNLGLIIFRDQ VVRYGCIRDHLRQTLLDMIARERKG EVVDRGAIRNACQMLMILGLEGRSV YEEDFEAPFLEMSAEFFQMESQKFL AENSASVYIKKVEARINEEIERVMH CLDKSTEEPIVKVVERELISKHMKT IVEMENSGLVHMLKNGKTEDLGCMY KLFSRVPNGLKTMCECMSSYLREQG KALVSEEGEGKNPVDYIQGLLDLKS RFDRFLLESFNNDRLFKQTIAGDFE YFLNLNSRSPEYLSLFIDDKLKKGV KGLTEQEVETILDKAMVLFRFMQEK DVFERYYKQHLARRLLTNKSVSDDS EKNMISKLKTECGCQFTSKLEGMFR DMSISNTTMDEFRQHLQATGVSLGG VDLTVRVLTTGYWPTQSATPKCNIP PAPRHAFEIFRRFYLAKHSGRQLTL QHHMGSADLNATFYGPVKKEDGSEV GVGGAQVTGSNTRKHILQVSTFQMT ILMLFNNREKYTFEEIQQETDIPER ELVRALQSLACGKPTQRVLTKEPKS KEIENGHIFTVNDQFTSKLHRVKIQ TVAAKQGESDPERKETRQKVDDDRK HEIEAAIVRIMKSRKKMQHNVLVAE VTQQLKARFLPSPVVIKKRIEGLIE REYLARTPEDRKVYTYVATRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
