CXCR7
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Official Full Name
chemokine (C-X-C motif) receptor 7 -
Overview
CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking -
Synonyms
CXCR7;chemokine (C-X-C motif) receptor 7;chemokine orphan receptor 1 , CMKOR1;C-X-C chemokine receptor type 7;GPR159;RDC1;G protein-coupled receptor;chemokine orphan receptor 1;G-protein coupled receptor 159;G-protein coupled receptor RDC1 homolo
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Chicken
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- Avi
- Fc
Involved Pathway
CXCR7 involved in several pathways and played different roles in them. We selected most pathways CXCR7 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL27,CCR9A,TNFSF8,IL20RB,IL11,VEGFA,TNFRSF1A,IFNE,BMP7A,IFNB1 |
Protein Function
CXCR7 has several biochemical functions, for example, C-X-C chemokine binding,C-X-C chemokine receptor activity,coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR7 itself. We selected most functions CXCR7 had, and list some proteins which have the same functions with CXCR7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-X-C chemokine receptor activity | CXCR4A,CXCR3,CXCR2,CCBP2,CCR9A,CXCR4,CXCR5,CXCR3.1,CXCR4B,CXCR6 |
| protein binding | NFKB1,RIN1,MST1R,BAAT,FSTL5,ATP5A1,WDR77,ZYX,ATG5,RGS8 |
| C-X-C chemokine binding | CXCR3,CXCR6,HMGB1 |
| scavenger receptor activity | PRG4,VTNA,VTN,COLEC12,ENPP2,PRG4A,HHIPL1,MARCO,TMPRSS4A,SRCRB4D |
| coreceptor activity | ACVR2A,RGMB,RGMA,TGFBR3,CD8B,PVRL2,ACKR3B,RGMD,CD8A,TMIGD2 |
Interacting Protein
CXCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR7.
PECAM1;GRB2;nirB;alaS;ATP13A2;MRPL4;ATP5H;ATP5B;ATP5A1;GJB2;ATP5O;CD164;ESPL1;HECTD2;UBR7
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References
- Shi, JY; Yang, LX; et al. CC chemokine receptor-like 1 functions as a tumour suppressor by impairing CCR7-related chemotaxis in hepatocellular carcinoma. JOURNAL OF PATHOLOGY 235:546-558(2015).
- Zhang, SS; Lv, C; et al. Corticosterone Mediates the Inhibitory Effect of Restraint Stress on the Migration of Mesenchymal Stem Cell to Carbon Tetrachloride-Induced Fibrotic Liver by Downregulating CXCR4/7 Expression. STEM CELLS AND DEVELOPMENT 24:587-596(2015).
