cyp19a1
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  • Official Full Name
  • cytochrome P450, family 19, subfamily A, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens);
Cat.#:CYP19A1-548HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP19A1 Protein, His-tagged
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Cat.#:ARO-3637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARO, His-tagged
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Cat.#:CYP19A1-145HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CYP19A1
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Cat.#:CYP19A1-158HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP19A1 protein, GST-tagged
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Cat.#:CYP19A1-26393THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP19A1
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Cat.#:CYP19A1-26421THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP19A1
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Cat.#:CYP19A1-432HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP19A1 protein
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Cat.#:CYP19A1-4148MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP19A1 Protein
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Cat.#:CYP19A1-1157CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP19A1
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Cat.#:CYP19A1-7127HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP19A1 293 Cell Lysate
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Involved Pathway

CYP19A1 involved in several pathways and played different roles in them. We selected most pathways CYP19A1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Endogenous sterols, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP19A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
UGT1B3; UGT1B7; CYP4T8; CYP3C1; CYP2V1; GGTLC1; CYP3A5; SLC26A2; SLC35B2; CYP2AD6
Cytochrome P450 - arranged by substrate type
CYP2AD6; CYP2K19; CYP46A1; CYP2J2; CYP3C4; CYP2K8; FDX1L; CYP27B1; CYP4B1; CYP3C1
Endogenous sterols
CYP7A1; CYP1B1; CYP51A1; CYP46A1; FDXR; CYP8B2; CYP17A1; CYP19A1; CYP11A1; POMCB
Estrogen biosynthesis
HSD17B11; CYP19A1; AKR1B15
FSH signaling pathway
CYP19A1; AREG; CGA
Integrated Breast Cancer Pathway
UBE2F; GRN; PLK3; NAB1; ALKBH1; MYT1; C21orf7; LGALS13; JAKMIP1; ERAL1
Metabolic pathways
ST6GALNAC4; PIGC; WBSCR17; EPT1; IDO1; HYAL6; COX7C; COASY; ACOT5; SI
Metabolism
AKR1C2; GLYATL1; PDP1; PLB1; ADAL; CYP17A1; SLC25A1A; CD320; SLC25A15B; GLTPD1

Protein Function

CYP19A1 has several biochemical functions, for example, aromatase activity, electron carrier activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP19A1 itself. We selected most functions CYP19A1 had, and list some proteins which have the same functions with CYP19A1. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP2C55; CYP2C70; CYP2A7; CYP3A43; CYP2C9; CYP2A12; CYP2C18; FAM84B; CYP2D6; CYP2F1
Function electron carrier activity
Related Protein GLRX2; ALDH4A1; TXNRD1; IDO1; COX7A2A; HSD17B6; AKR1B1; PTGESL; CIAPIN1; ACOX1
Function heme binding
Related Protein CYP2AA4; CYP2AD6; CYP4F11; CYP2C55; CYP2A7; CYP2K17; CYP2C37; CYP2X9; CYP8B1; CYB5R4
Function iron ion binding
Related Protein CYP2D6; HBAD; ACO2; CYP2C19; CYP3A4; CYP4B1; PLOD1A; CYP1A4; CYP2AD2; CYP51
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2K16; CYP2D26; CYP2D6; CYP2P8; CYP2C8; CYP2AA12; CYP2J2; CYP2A4; CYP2S1; CYP2A12
Function oxygen binding
Related Protein CYP2A4; CBS; CYP2E1; CYP4B1; CYP2Y3; HBB-B2; Adgb; CYP2U1; HBA2; CYP2C19

Interacting Protein

CYP19A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP19A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP19A1.
A2M

CYP19A1 Related Articles

Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).