CYP21A2 Protein, cytochrome P450, family 21, subfamily A, polypeptide 2

CYP21A2

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CYP21A2

Official Full Name cytochrome P450, family 21, subfamily A, polypeptide 2
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms CYP21A2; cytochrome P450, family 21, subfamily A, polypeptide 2; CYP21, CYP21B, cytochrome P450, subfamily XXIA (steroid 21 hydroxylase, congenital adrenal hyperplasia), polypeptide 2; steroid 21-hydroxylase; CA21H; CAH1; CPS1; P450c21B; Steroid 21 monooxygenase; CYP21; CYP21B; P450 C21; P450 C21B; Steroid 21 hydroxylase; CYP21A 2; Cytochrome P450 21; 21-OHase; cytochrome P450 XXI; cytochrome P450-C21B; steroid 21-monooxygenase; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP21A2-447H Recombinant Human CYP21A2 Protein (1-494 aa), His-tagged E.coli His
    Human CYP21A2-1180H Recombinant Human CYP21A2 Protein, His-tagged Yeast His
    Human CYP21A2-2249H Recombinant Human CYP21A2 Protein, GST-tagged Wheat Germ GST
    Human CYP21A2-7119H Recombinant Human CYP21A2 protein, His & T7-tagged E.coli His/T7
    Human CYP21A2-7123HCL Recombinant Human CYP21A2 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CYP21A2-1139R Recombinant Rhesus monkey CYP21A2 Protein, His-tagged Mammalian Cell His
    Chicken CYP21A2-3723C Recombinant Chicken CYP21A2 Mammalian Cell His

    CYP21A2 involved in several pathways and played different roles in them. We selected most pathways CYP21A2 participated on our site, such as Aldosterone synthesis and secretion, Biological oxidations, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP21A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretion ATF6B; NR4A1; CALML3; CAMK2B; PRKD1; PLCB3; PRKCA; CAMK1G; PRKACB; PRKCB
    Biological oxidations ABHD10; SLC26A1; CYP3A4; GSTK1; SULT1C2; CYP11B2; CYP2K19; UGT1B4; CYP2AD6; GSTO2
    Corticotropin-releasing hormone TBX19; JUNB; TCF4; ADRBK2; CRHR2; CRHR1; CYP11A1; CASP12; CRHBP; CYP11B1
    Cytochrome P450 - arranged by substrate type CYP3A7; CYP4F11; FDX1; FAM84B; CYP2AD6; CYP2C8; CYP2W1; CYP24A1; CYP3C4; CYP2B6
    Endogenous sterols CYP46A1; POMCB; CYP11B2; CYP1B1; CYP27A1; CYP11B1; CYP7A1; CYP51A1; CYP19A1; FDX1
    Glucocorticoid &amp CYP21A2; CYP11B2; CYP17A1; AKR1C21
    amp CYP17A1; AKR1C21; CYP11B2; CYP21A2
    Mineralcorticoid Metabolism CYP21A2; AKR1C21; CYP17A1; CYP11B2
    Glucocorticoid biosynthesis CYP17A1; CYP11B1; CYP21A2; CYP11B2
    Metabolic pathways ACMSD; ANPEP; SPHK2; ZNF408; CBSB; MTHFS; AKR1C4; AGXT2L1; LASS1; RPE

    CYP21A2 has several biochemical functions, for example, heme binding, iron ion binding, steroid 21-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP21A2 itself. We selected most functions CYP21A2 had, and list some proteins which have the same functions with CYP21A2. You can find most of the proteins on our site.

    Function Related Protein
    heme binding NOX4; SRC; CYP51A1; CYGB1; CYP4F22; PTGESL; HBB-B2; CYP46A1.3; CYP2C55; CYP1B1
    iron ion binding CYP2D26; CYP2AA6; NDOR1; CYP4F14; HBAA1; CYP2V1; BBOX1; FTH1; CYP2C9; CYP2J5
    steroid 21-monooxygenase activity CYP21A1; CYP21A2
    steroid binding UGT1A1; PAQR5; ESR2; NR3C1; Ar; HSD3B4; ESR1; CYP3A4; ESR2B; PAQR7A
    steroid hydroxylase activity CYP2K6; CYP2AA9; CYP2C38; CYP2A12; CYP2K22; CYP2C70; CYP2C54; CYP2X9; CYP2AA12; CYP2F1

    CYP21A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP21A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP21A2.

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