CYP27A1 Protein, cytochrome P450, family 27, subfamily A, polypeptide 1


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Official Full Name cytochrome P450, family 27, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
Synonyms CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1; CYP27, cytochrome P450, subfamily XXVIIA (steroid 27 hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; sterol 26-hydroxylase, mitochondrial; cerebrotendinous xanthomatosis; CP27; CTX; Sterol 26 hydroxylase; Sterol 27 hydroxylase; Vitamin D(3) 25hydroxylase; CYP; CYP27; Cytochrome P450 27 mitochondrial; cytochrome P450 27; sterol 27-hydroxylase; cytochrome P-450C27/25; vitamin D(3) 25-hydroxylase; cholestanetriol 26-monooxygenase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cyp27a1-250M Recombinant Mouse Cyp27a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CYP27A1-2253H Recombinant Human CYP27A1 Protein, GST-tagged Wheat Germ GST
    Human CYP27A1-7119HCL Recombinant Human CYP27A1 293 Cell Lysate HEK293 N/A
    Mouse CYP27A1-4156M Recombinant Mouse CYP27A1 Protein Mammalian Cell His
    Rat CYP27A1-1721R Recombinant Rat CYP27A1 Protein Mammalian Cell His
    Rhesus Macaque CYP27A1-1141R Recombinant Rhesus monkey CYP27A1 Protein, His-tagged Mammalian Cell His

    CYP27A1 involved in several pathways and played different roles in them. We selected most pathways CYP27A1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP27A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile acid and bile salt metabolism NCOA2; AKR1C2; CYP27A1; AKR1C4; SLC27A2A; SLC27A2; AKR1C6; Alb; AKR1C21; CYP46A1
    Biological oxidations ADH1A; SULT1B1; CYP1B1; AADAC; ACY3.2; CYP2J2; AS3MT; CYP2N13; CYP2F1; PAOX
    Cytochrome P450 - arranged by substrate type FAM84B; CYP27B1; CYP2V1; CYP3C1; CYP27A1; CYP2C9; CYP1A1; CYP2J2; CYP2Y3; CYP2A7
    Endogenous sterols FDXR; CYP21A2; CYP1B1; FDX1; CYP7A1; CYP17A1; FDX1L; CYP11B2; POMCB; CYP11A1
    Metabolic pathways QRSL1; GGT7; UGT1A1; PLCZ1; ACOX2; SORD; PGAM1; ATP6V1BA; LASS1; ACAA2
    Metabolism CYP2B6; B3GNT1; ELA2L; GNG13B; SACM1L; CYP3A7-CYP3AP1; ADSSL1; CYB5R3; APOA5; LYRM4
    Metabolism of lipids and lipoproteins CEPT1A; MED18; INSIG1; ECI1; PPM1LA; CYP2Y3; NFYBA; FAM213B; YAP1; MTF1
    PPAR signaling pathway PDPK1; CYP4A14; RXRB; FABP7A; CYP4A10; ACAA1A; CPT1C; CYP7A1A; Scd2; PPARAB

    CYP27A1 has several biochemical functions, for example, cholestanetriol 26-monooxygenase activity, cholesterol 26-hydroxylase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP27A1 itself. We selected most functions CYP27A1 had, and list some proteins which have the same functions with CYP27A1. You can find most of the proteins on our site.

    Function Related Protein
    cholestanetriol 26-monooxygenase activity CYP27A1
    cholesterol 26-hydroxylase activity CYP27A1
    heme binding HBAD; NGB; CYP11C1; CYP2P9; MFSD7C; CYP17A2; IDO1; HBE; IRGM1; CYP4A12A
    iron ion binding CYP27A1; CYP26C1; CYP1C1; CYP2C39; CYP4V8; CYP2Y3; TH2; CYP2C55; ALOX15B; CYP2D10
    steroid hydroxylase activity CYP2P9; CYP2N13; CYP2F2; CYP2B19; CYP2C39; CYP2C19; CYP2F1; CYP2P10; CYP2J2; BRSK2
    vitamin D3 25-hydroxylase activity CYP2R1; CYP27A1; CYP3A4; FAM84B

    CYP27A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP27A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP27A1.


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