CYP2D6
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Official Full Name
Cytochrome P450, Family 2, Subfamily D, Polypeptide 6
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390; CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450 2D6; OTTHUMP00000198705; OTTHUMP00000198706; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; P450 DB1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
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- E. coli
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- Mammalian cells
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- Sf9 insect cells
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP2D6 Related Articles
CYP2D6 involved in several pathways and played different roles in them. We selected most pathways CYP2D6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2D6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Biological oxidations | CYP2AD6;CYP1A2;CYP2U1;FDX1;ADH1A;DPEP1;CYP2A6;UGT1B7;CYP4A11 |
CYP2E1 reactions | CYP2F1;CYP2A13;CYP2A7;CYP2C9;CYP2E1;CYP2S1;CYP2C8;CYP2C19;CYP2Y3 |
Cytochrome P450 - arranged by substrate type | CYP1A1;FDXR;CYP21A2;FAM84B;CYP2C9;CYP2C18;CYP2K6;CYP2K8;CYP2K18 |
Drug metabolism - cytochrome P450 | CYP2C8;GSTK1;ADH1B;ADH1A;ADH2-2;CYP2E1;ADH2-1;CYP2D6;CYP2C9 |
Fatty Acid Omega Oxidation | CYP2D6;CYP2A6;CYP1A1;ADH1C;ADH1A;ADH4;ADH6;ADH7;ADH1B |
Fatty acids | CYP2D6;CYP4F11;CYP4B1;CYP2B6;CYP2V1;CYP2J2;CYP2AD2;CYP4T8;CYP2A7 |
Metabolism | DLAT;FTCD;KCNS3;MED10;COX11;CYP3C1;PTGR1;CYP2K18;SULT2ST2 |
CYP2D6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2D6 itself. We selected most functions CYP2D6 had, and list some proteins which have the same functions with CYP2D6. You can find most of the proteins on our site.
Function | Related Protein |
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arachidonic acid epoxygenase activity | CYP2S1;CYP2F1;CYP2AA12;CYP2AA1;CYP2D6;CYP4A10;CYP2AA2;CYP2J5;CYP2C8 |
aromatase activity | CYP2U1;CYP4F12;CYP3A43;CYP2C39;CYP2C9;CYP2C54;CYP2A13;CYP1D1;CYP2B19 |
drug binding | PDE10A;FSCN1;CHRNA3;P2RX2;DHODH;FASN;PDE2A;HTR1B;SETD6 |
heme binding | CYP4F11;CYP26B1;CYP4F3;NENF;CYP4F18;CYP11C1;HBQ1;HBG2;HBE |
iron ion binding | CYP3C1L2;NFU1;P4HA1B;KDM3A;CYP2K22;CYP46A1.2;HBAE1;CYP1A;CYP1D1 |
monooxygenase activity | CYP1A1;CYP46A1.4;CYP4F22;TPH1A;CYP3C4;CYP3C1L2;CYP51;CYP2V1;CYP2C70 |
oxidoreductase activity | DHRS12;DHRS13;SDR16C5A;RNLS;GPD1;CYP2AA12;P4HA1B;CYP4A14;ACOXL |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2AA8;CYP1A;CYP2W1;CYP2F2;CYP1B1;CYP2A4;CYP2X9;CYP2E1;CYP2C9 |
oxygen binding | CBS;CYP2U1;CYP1A1;HBD;CYP2D10;HBAE3;CYP2C39;HBE1;HBAE1 |
steroid hydroxylase activity | CYP2A13;CYP2AA4;CYP2AD6;FAM84B;CYP2W1;CH25H;CYP2C38;CYP2AA2;CYP2U1 |
CYP2D6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2D6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2D6.
- Q&As
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Q&As (5)
Ask a questionKnowing a patient's CYP2D6 genotype can help tailor drug therapy, optimizing dosage and minimizing the risk of adverse effects.
Genetic variations can result in different CYP2D6 phenotypes, influencing an individual's ability to metabolize drugs efficiently.
Certain ethnic groups may have a higher prevalence of CYP2D6 polymorphisms, influencing drug response variability among different populations.
CYP2D6 polymorphisms can lead to variations in drug response and efficacy, affecting the dosage and choice of medications for patients.
CYP2D6 testing can guide personalized medicine by helping clinicians choose the most appropriate medications and dosages for individual patients.
Customer Reviews (3)
Write a reviewOne remarkable aspect of working with the CYP2D6 protein is the excellent technical support provided by its manufacturer.
The CYP2D6 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.
With its reliable performance and consistent results, the CYP2D6 protein provides researchers with the confidence and accuracy required for successful experimentation.
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