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CYP2D6

  • Official Full Name

    Cytochrome P450, Family 2, Subfamily D, Polypeptide 6

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390; CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450 2D6; OTTHUMP00000198705; OTTHUMP00000198706; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; P450 DB1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Pig
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • P.pastoris
  • Sf9 insect cells
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2D6-7965H Recombinant Human CYP2D6 protein, His-tagged E.coli His Leu236~Gln472 (Accession # P10635)
Human CYP2D6-26689TH Recombinant Human CYP2D6 N/A
Human CYP2D6-11775H Recombinant Human CYP2D6, GST-tagged E.coli GST 148-497a.a.
Human CYP2D6-250H Recombinant Human CYP2D6 Insect Cell N/A
Human CYP2D6-34H Recombinant Human CYP2D6/NADPH reductase protein P.pastoris N/A
Human CYP2D6-7112HCL Recombinant Human CYP2D6 293 Cell Lysate HEK293 N/A
Human CYP2D6-01H Recombinant Human CYP2D6 Protein Sf9 insect cells
Human CYP2D6-78H Active Recombinant Human CYP2D6 Protein E. coli
Human CYP2D6-49H Active Recombinant Human CYP2D6 Protein E.coli
Human CYP2D6-3401H Recombinant Human CYP2D6 Protein, DDK-tagged HEK293 DDK
Human CYP2D6-1918HFL Recombinant Full Length Human CYP2D6 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP2D6-0003H Recombinant Human CYP2D6 Protein (P34-R497), Tag Free E.coli No tag P34-R497
Human CYP2D6-703H Recombinant Human CYP2D6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP2D6-703H-B Recombinant Human CYP2D6 Protein Pre-coupled Magnetic Beads HEK293
Human CYP2D6-0004H Recombinant Human CYP2D6 Protein (P34-R497), His tagged E.coli His P34-R497
Rhesus Macaque CYP2D6-1153R Recombinant Rhesus monkey CYP2D6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP2D6-978R Recombinant Rhesus Macaque CYP2D6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYP2D6-978R-B Recombinant Rhesus Macaque CYP2D6 Protein Pre-coupled Magnetic Beads HEK293
Pig CYP2D6-136P Recombinant Pig CYP2D6 Protein E. coli
Chicken CYP2D6-4143C Recombinant Chicken CYP2D6 Mammalian Cell His
Kit-2134 Cytochrome P450 2D6 Fluorometric Activity Assay Kit N/A
Kit-2135 Cytochrome P450 2D6 Inhibitor Screening Kit N/A
Kit-0940 CYP2D6 Blue Screening Kit N/A
Kit-0902 CYP2D6 Cyan Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2D6 Related Articles

CYP2D6 involved in several pathways and played different roles in them. We selected most pathways CYP2D6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2D6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsCYP2AD6;CYP1A2;CYP2U1;FDX1;ADH1A;DPEP1;CYP2A6;UGT1B7;CYP4A11
CYP2E1 reactionsCYP2F1;CYP2A13;CYP2A7;CYP2C9;CYP2E1;CYP2S1;CYP2C8;CYP2C19;CYP2Y3
Cytochrome P450 - arranged by substrate typeCYP1A1;FDXR;CYP21A2;FAM84B;CYP2C9;CYP2C18;CYP2K6;CYP2K8;CYP2K18
Drug metabolism - cytochrome P450CYP2C8;GSTK1;ADH1B;ADH1A;ADH2-2;CYP2E1;ADH2-1;CYP2D6;CYP2C9
Fatty Acid Omega OxidationCYP2D6;CYP2A6;CYP1A1;ADH1C;ADH1A;ADH4;ADH6;ADH7;ADH1B
Fatty acidsCYP2D6;CYP4F11;CYP4B1;CYP2B6;CYP2V1;CYP2J2;CYP2AD2;CYP4T8;CYP2A7
MetabolismDLAT;FTCD;KCNS3;MED10;COX11;CYP3C1;PTGR1;CYP2K18;SULT2ST2

CYP2D6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2D6 itself. We selected most functions CYP2D6 had, and list some proteins which have the same functions with CYP2D6. You can find most of the proteins on our site.

Function Related Protein
arachidonic acid epoxygenase activityCYP2S1;CYP2F1;CYP2AA12;CYP2AA1;CYP2D6;CYP4A10;CYP2AA2;CYP2J5;CYP2C8
aromatase activityCYP2U1;CYP4F12;CYP3A43;CYP2C39;CYP2C9;CYP2C54;CYP2A13;CYP1D1;CYP2B19
drug bindingPDE10A;FSCN1;CHRNA3;P2RX2;DHODH;FASN;PDE2A;HTR1B;SETD6
heme bindingCYP4F11;CYP26B1;CYP4F3;NENF;CYP4F18;CYP11C1;HBQ1;HBG2;HBE
iron ion bindingCYP3C1L2;NFU1;P4HA1B;KDM3A;CYP2K22;CYP46A1.2;HBAE1;CYP1A;CYP1D1
monooxygenase activityCYP1A1;CYP46A1.4;CYP4F22;TPH1A;CYP3C4;CYP3C1L2;CYP51;CYP2V1;CYP2C70
oxidoreductase activityDHRS12;DHRS13;SDR16C5A;RNLS;GPD1;CYP2AA12;P4HA1B;CYP4A14;ACOXL
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2AA8;CYP1A;CYP2W1;CYP2F2;CYP1B1;CYP2A4;CYP2X9;CYP2E1;CYP2C9
oxygen bindingCBS;CYP2U1;CYP1A1;HBD;CYP2D10;HBAE3;CYP2C39;HBE1;HBAE1
steroid hydroxylase activityCYP2A13;CYP2AA4;CYP2AD6;FAM84B;CYP2W1;CH25H;CYP2C38;CYP2AA2;CYP2U1

CYP2D6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2D6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2D6.

Wang, DX; Papp, AC; et al. Functional characterization of CYP2D6 enhancer polymorphisms. HUMAN MOLECULAR GENETICS 24:1556-1562(2015).
Hintermann, E; Ehser, J; et al. Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. JOURNAL OF AUTOIMMUNITY 44:49-60(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How can knowledge of a patient's CYP2D6 genotype impact drug prescribing? 04/08/2023

Knowing a patient's CYP2D6 genotype can help tailor drug therapy, optimizing dosage and minimizing the risk of adverse effects.

How does genetic variability impact the activity of CYP2D6? 07/19/2022

Genetic variations can result in different CYP2D6 phenotypes, influencing an individual's ability to metabolize drugs efficiently.

Are there specific populations that exhibit higher frequencies of CYP2D6 polymorphisms? 03/21/2021

Certain ethnic groups may have a higher prevalence of CYP2D6 polymorphisms, influencing drug response variability among different populations.

What are the clinical implications of CYP2D6 polymorphisms in drug metabolism? 07/23/2020

CYP2D6 polymorphisms can lead to variations in drug response and efficacy, affecting the dosage and choice of medications for patients.

How can CYP2D6 testing be utilized in personalized medicine? 03/18/2019

CYP2D6 testing can guide personalized medicine by helping clinicians choose the most appropriate medications and dosages for individual patients.

Customer Reviews (3)

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Reviews
01/26/2023

    One remarkable aspect of working with the CYP2D6 protein is the excellent technical support provided by its manufacturer.

    08/15/2022

      The CYP2D6 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/09/2016

        With its reliable performance and consistent results, the CYP2D6 protein provides researchers with the confidence and accuracy required for successful experimentation.

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