CYP2D6

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CYP2D6

Official Full Name Cytochrome P450, Family 2, Subfamily D, Polypeptide 6
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390; CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450 2D6; OTTHUMP00000198705; OTTHUMP00000198706; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; P450 DB1
    • Species :
    • Chicken
    • Human
    • Pig
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • P.pastoris
    • Tag :
    • DDK
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Pig CYP2D6-136P Recombinant Pig CYP2D6 Protein E. coli
    Human CYP2D6-49H Recombinant Human CYP2D6 Protein E.coli
    Human CYP2D6-78H Recombinant Human CYP2D6 Protein E. coli
    Human CYP2D6-11775H Recombinant Human CYP2D6, GST-tagged E.coli GST
    Human CYP2D6-250H Recombinant Human CYP2D6 Insect Cell N/A
    Human CYP2D6-26689TH Recombinant Human CYP2D6 N/A
    Human CYP2D6-3401H Recombinant Human CYP2D6 Protein, DDK-tagged HEK293 DDK
    Human CYP2D6-34H Recombinant Human CYP2D6/NADPH reductase protein P.pastoris N/A
    Human CYP2D6-7112HCL Recombinant Human CYP2D6 293 Cell Lysate HEK293 N/A
    Human CYP2D6-7965H Recombinant Human CYP2D6 protein, His-tagged E.coli His
    Rhesus Macaque CYP2D6-1153R Recombinant Rhesus monkey CYP2D6 Protein, His-tagged Mammalian Cell His
    Chicken CYP2D6-4143C Recombinant Chicken CYP2D6 Mammalian Cell His
    Kit-0902 CYP2D6 Cyan Screening Kit N/A
    Kit-0940 CYP2D6 Blue Screening Kit N/A
    Kit-2134 Cytochrome P450 2D6 Fluorometric Activity Assay Kit N/A
    Kit-2135 Cytochrome P450 2D6 Inhibitor Screening Kit N/A

    CYP2D6 involved in several pathways and played different roles in them. We selected most pathways CYP2D6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Codeine and morphine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2D6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations ADH8A; CYP3C4; CYP3A5; UGT1B5; SULT1ST6; ADH1A; CYP21A2; SLC35B3; CYP4B1; CYP3C1
    CYP2E1 reactions CYP2B6; CYP2A7; CYP2C9; CYP2C8; CYP2Y3; CYP2A6; CYP2F1; CYP2C19; CYP2E1; CYP2A13
    Codeine and morphine metabolism FAM84B; SLCO1B1; CYP3A4; CYP2D6; ABCC2
    Cytochrome P450 - arranged by substrate type CYP2V1; CYP2J2; CYP24A1; CYP4F22; CYP4F11; CYP11B2; CYP2AD2; CYP2F1; CYP17A1; CYP51A1
    Drug metabolism - cytochrome P450 GSTO2; CYP2C8; ADH1B; CYP2D6; CYP2E1; CYP3A5; ADH4; CYP2C19; ADH7; CYP2C9
    Fatty Acid Omega Oxidation CYP1A1; ADH1A; CYP4A11; ADH6; ADH1C; ADH7; ADH4; ADH1B; CYP2D6; CYP2E1
    Fatty acids CYP2A13; CYP2B6; CYP2N13; CYP4F22; CYP4B1; CYP2J2; CYP4A11; CYP2D6; CYP2A7; CYP4T8
    Metabolism AK7; ARSD; SLC5A6B; UCP3; DPYD; CKMT2A; DSEL; SLC5A4; ARSE; MED23

    CYP2D6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2D6 itself. We selected most functions CYP2D6 had, and list some proteins which have the same functions with CYP2D6. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2P9; CYP2C8; CYP2AA2; CYP2C9; CYP2P7; CYP2J6; CYP2D10; CYP2D6; CYP2C39; CYP2AA4
    aromatase activity CYP4Z1; CYP2J2; CYP1A2; CYP4X1; CYP4A12A; CYP4F12; CYP2A13; CYP2J5; CYP3A4; CYP3A25
    drug binding FSCN1; NR1I2; MT2A; CYP2C9; PDXK; SRP54; CHRM3; CHRNB4; TYMS; ADRB2
    heme binding CYP2J2; HBD; CYP4A14; CYBB; SDHDA; PTGS2A; HBA-X; CYP4A12A; CYP24A1; CYP2P10
    iron ion binding CH25HL2; HBG1; ALOX5A; CYP19A1; ALOX5B.3; CYP1A4; CYP27A1; CYP2K16; TPH1B; CYP51
    monooxygenase activity CYP2AA12; CYP2P7; CYP1A1; CYP11C1; CYP2AA8; CYP2AA2; YWHAE2; CYP2AA1; CYP4A10; YWHAE1
    oxidoreductase activity HSD3B5; CYP3C1L2; ALDH2.1; CYP2Y3; AOC1; DCT; ALOX5B.3; TDH; AKR1E1; CYP4A12A
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2K6; CYP2AA3; CYP2P8; CYP1A; CYP2A4; CYP2D10; CYP2V1; CYP1B1; CYP2AA6; CYP2AA7
    oxygen binding CYP2C8; HBD; CYP2C55; CYP2AD6; HBAA; CYP2AA12; CYP2F1; CYP2C54; CYGB; CYP2B19
    steroid hydroxylase activity CYP2AD3; CYP2C50; CYP2C70; CYP3A4; CYP2V1; CYP2AA12; CYP2AA9; CYP2A12; CYP2W1; CYP2K16

    CYP2D6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2D6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2D6.

    Wang, DX; Papp, AC; et al. Functional characterization of CYP2D6 enhancer polymorphisms. HUMAN MOLECULAR GENETICS 24:1556-1562(2015).
    Hintermann, E; Ehser, J; et al. Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. JOURNAL OF AUTOIMMUNITY 44:49-60(2013).

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