cyp2d6
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  • Official Full Name
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 6
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390; CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450 2D6; OTTHUMP00000198705; OTTHUMP00000198706; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; P450 DB1
Cat.#:CYP2D6-3401HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2D6 Protein, DDK-tagged
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Cat.#:CYP2D6-11775HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2D6, GST-tagged
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Cat.#:CYP2D6-250HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2D6
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Cat.#:CYP2D6-26689THTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2D6
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Cat.#:CYP2D6-34HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human CYP2D6/NADPH reductase protein
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Cat.#:CYP2D6-7965HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2D6 protein, His-tagged
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Cat.#:CYP2D6-1153RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2D6 Protein, His-tagged
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Cat.#:CYP2D6-4143CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP2D6
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Cat.#:CYP2D6-7112HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2D6 293 Cell Lysate
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Cat.#:Kit-2134Tag:
Source (Host):Species:
Product nameCytochrome P450 2D6 Fluorometric Activity Assay Kit
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Cat.#:Kit-2135Tag:
Source (Host):Species:
Product nameCytochrome P450 2D6 Inhibitor Screening Kit
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Cat.#:Kit-0902Tag:
Source (Host):Species:
Product nameCYP2D6 Cyan Screening Kit
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Cat.#:Kit-0940Tag:
Source (Host):Species:
Product nameCYP2D6 Blue Screening Kit
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Involved Pathway

CYP2D6 involved in several pathways and played different roles in them. We selected most pathways CYP2D6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Codeine and morphine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2D6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CYP3A5; CYP2J2; SULT1C2; CYP2R1; UGT1B7; FDX1L; CYP11B1; ADH6; CYP2U1; ADH8B
CYP2E1 reactions
CYP2F1; CYP2E1; CYP2B6; CYP2C19; CYP2C9; CYP2Y3; CYP2C8; CYP2A13; CYP2D6; CYP2A7
Codeine and morphine metabolism
CYP2D6; ABCC2; CYP3A4; FAM84B; SLCO1B1
Cytochrome P450 - arranged by substrate type
CYP3A7-CYP3AP1; CYP2A6; CYP2V1; CYP11B1; CYP17A1; CYP3C1; CYP2E1; CYP26A1; CYP2Y3; CYP2C8
Drug metabolism - cytochrome P450
ADH1B; ADH7; CYP2C19; ADH1C; GSTK1; CYP3A5; CYP2C8; CYP2A6; ADH1A; ADH2-2
Fatty Acid Omega Oxidation
ADH1C; CYP2D6; CYP2A6; ADH7; CYP2E1; ADH1B; ADH4; ADH6; CYP4A11; ADH1A
Fatty acids
CYP4A11; CYP4B1; CYP4T8; CYP2B6; CYP2AD2; CYP4F11; CYP2D6; CYP2F1; CYP2A13; CYP2A7
Metabolism
COL4A3BP; NAGS; MED29; SLC25A11; AK7; PCBD1; GC; PNPLA8; Sult2a6; MED18

Protein Function

CYP2D6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2D6 itself. We selected most functions CYP2D6 had, and list some proteins which have the same functions with CYP2D6. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2D10; CYP2C70; CYP2C54; CYP2AD6; CYP2F1; CYP2AA1; CYP2C37; CYP2C55; CYP4A10; CYP2B19
Function aromatase activity
Related Protein CYP2S1; CYP2D9; CYP3A4; CYP1A2; CYP2D26; CYP2C55; CYP2C38; CYP1D1; CYP2A7; CYP4X1
Function drug binding
Related Protein FABP1; SLC6A4A; HTR2A; HMGCS1; CYP2C9; TLR8; P2RX2; FNTB; HMGB2; MT2A
Function heme binding
Related Protein CYP2K6; HBB-B2; XGB; SDHDA; CYP2P9; MFSD7C; AMBP; HBE1; CYP46A1.4; CYB5A
Function iron ion binding
Related Protein CYP2K18; CYP2AA6; CYP4A12A; PLOD3; FAM125B; CYP11A1; CYP2C70; AOX4; IRGM1; CYP4F12
Function monooxygenase activity
Related Protein CYP7A1A; CYP46A1.2; CYP51; FAM84B; CYP2P9; COQ6; CYP4T8; CYP2C54; YWHABL; CYP1A2
Function oxidoreductase activity
Related Protein HSD17B12B; SDR16C5A; RETSATL; HSD17B12A; DIO3A; CYP2AA9; KDM1B; RPS6KL1; CYP46A1.2; MOXD2
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2A6; CYP2K19; CYP2P9; CYP2K16; CYP2C50; CYP2B6; CYP2A7; CYP2Y3; CYP2C38; CYP2X10.2
Function oxygen binding
Related Protein FAM84B; CYP2X7; CYP2C70; HBA1; Adgb; HBE; CYP2AD2; CYP2K6; CYP26A1; CYP17A1
Function steroid hydroxylase activity
Related Protein CYP2B6; CYP2AA7; CYP46A1.3; CYP2J5; CYP2C38; CYP2R1; CYP2P10; CYP2D9; CYP2D6; CYP2K22

CYP2D6 Related Articles

Wang, DX; Papp, AC; et al. Functional characterization of CYP2D6 enhancer polymorphisms. HUMAN MOLECULAR GENETICS 24:1556-1562(2015).
Hintermann, E; Ehser, J; et al. Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. JOURNAL OF AUTOIMMUNITY 44:49-60(2013).