Recombinant Human CYP2D6 protein, His-tagged


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Recombinant Human CYP2D6 protein, His-tagged

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Cat.No. : CYP2D6-7965H
Product Overview : Recombinant Human CYP2D6 aa. (Leu236~Gln472 (Accession # P10635)) fused with N-terminal His tag was produced in E. coli cells.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 28.4kDa
Protein length : Leu236~Gln472 (Accession # P10635)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in ddH2O.

Gene Name : CYP2D6 cytochrome P450 family 2 subfamily D member 6 [ Homo sapiens (human) ]
Official Symbol : CYP2D6
Synonyms : CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; cytochrome P450 2D6; CYP2D8P2; P450-DB1; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450-DB1; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; xenobiotic monooxygenase
Gene ID : 1565
mRNA Refseq : NM_000106.5
Protein Refseq : NP_000097.3
UniProt ID : P10635

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Related Gene

CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 CYP1B1 CYP24A1 CYP2J2 CYP46A1 CYP7B1 CYP1A2 CYP19A1 CYP26A1 CYP26B1 CYP2A6 CYP3A5 CYP3A7 CYP4F11 CYP4F3 CYP7A1 CYP2C6 CYP3A23/3A1 CYP1A1 CYP2B6 CYP4A11 Cyp11a1 CYP2C8 CYP2D4 CYP3A2 CYP2C18 CYP3A43 CYP4B1 CYP2U1 CYP2W1 CYP39A1 CYP2D1 CYP2R1 CYP26C1 CYP27A1 CYP2S1 CYP2C11 CYP4V2 CYP4X1 CYP4Z1 CYP11B1 CYP19A1B CYP4F12 CYP4F2 CYP4F22 CYP38 CYP27B1 CYP27C1 CYP2A13 CYP2A7 CYP20A1 CYP21A2 CYP4F8 CYP17A1 CYP2C23 CYP4A22 CYP4F13 Cyp2a1 Cyp2a12 Cyp2b3 Cyp2b9 Cyp2c12 Cyp2c13 Cyp2c22 Cyp2c29 Cyp2c38 Cyp2c39 Cyp2c40 Cyp2c44 Cyp2c50 Cyp2c54 Cyp2d11 Cyp2d12 Cyp2d2 Cyp2d22 Cyp2d26 Cyp2d3 Cyp2d34 Cyp2d40 Cyp2d5 Cyp2d9 Cyp2f2 Cyp2f4 Cyp2g1 Cyp2c37 Cyp21a1 Cyp3a11 Cyp3a13 Cyp3a16 Cyp3a18 Cyp3a25 Cyp3a41a Cyp3a41b Cyp3a57 Cyp4a31 Cyp4a32 Cyp4a8 Cyp4f1 Cyp4f14 Cyp4f15 Cyp4f17 Cyp4f18 Cyp4f6 Cyp4v3 Cyp51 CYP8B1 Cyp11b2 Cyp11b3 Cyp2a2 Cyp2a22 Cyp2a3 Cyp2a4 Cyp2a5 Cyp2ab1 Cyp2b1 Cyp2b10 Cyp2b12 Cyp2b13 Cyp2b15 Cyp2b19 Cyp2b21 Cyp2b23 Cyp2c6v1 Cyp2c65 Cyp2c66 Cyp2c67 Cyp2c68 Cyp2c69 Cyp2c7 CYP2F1 Cyp2j10 Cyp2j12 Cyp2j13 Cyp2j4 Cyp2j8 Cyp2j9 Cyp2t1 Cyp2t4 Cyp3a23 Cyp3a44 Cyp3a62 Cyp3a9 Cyp4a1 Cyp4a12a Cyp4a12b Cyp4a14 Cyp4a2 Cyp4a29 Cyp4a3 Cyp4a30b Cyp4f39 Cyp4f4 Cyp4f40 Cyp4f5 CYP51A1 Cyp3a59 CYP1B1-AS1 CYP2B7P1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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