Recombinant Human CYP2D6 protein, His-tagged
Cat.No. : | CYP2D6-7965H |
Product Overview : | Recombinant Human CYP2D6 aa. (Leu236~Gln472 (Accession # P10635)) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 28.4kDa |
Protein length : | Leu236~Gln472 (Accession # P10635) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 6. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage Buffer : | Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative. |
Reconstitution : | Reconstitute in ddH2O. |
Gene Name : | CYP2D6 cytochrome P450 family 2 subfamily D member 6 [ Homo sapiens (human) ] |
Official Symbol : | CYP2D6 |
Synonyms : | CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; cytochrome P450 2D6; CYP2D8P2; P450-DB1; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450-DB1; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; xenobiotic monooxygenase |
Gene ID : | 1565 |
mRNA Refseq : | NM_000106.5 |
Protein Refseq : | NP_000097.3 |
UniProt ID : | P10635 |
Products Types
◆ Recombinant Protein | ||
CYP2D6-978R | Recombinant Rhesus Macaque CYP2D6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CYP2D6-0003H | Recombinant Human CYP2D6 Protein (P34-R497), Tag Free | +Inquiry |
CYP2D6-703H | Recombinant Human CYP2D6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CYP2D6-49H | Active Recombinant Human CYP2D6 Protein | +Inquiry |
CYP2D6-0004H | Recombinant Human CYP2D6 Protein (P34-R497), His tagged | +Inquiry |
◆ Lysates | ||
CYP2D6-7112HCL | Recombinant Human CYP2D6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2135 | Cytochrome P450 2D6 Inhibitor Screening Kit | +Inquiry |
Kit-2134 | Cytochrome P450 2D6 Fluorometric Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionKnowing a patient's CYP2D6 genotype can help tailor drug therapy, optimizing dosage and minimizing the risk of adverse effects.
Genetic variations can result in different CYP2D6 phenotypes, influencing an individual's ability to metabolize drugs efficiently.
Certain ethnic groups may have a higher prevalence of CYP2D6 polymorphisms, influencing drug response variability among different populations.
CYP2D6 polymorphisms can lead to variations in drug response and efficacy, affecting the dosage and choice of medications for patients.
CYP2D6 testing can guide personalized medicine by helping clinicians choose the most appropriate medications and dosages for individual patients.
Customer Reviews (3)
Write a reviewOne remarkable aspect of working with the CYP2D6 protein is the excellent technical support provided by its manufacturer.
The CYP2D6 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.
With its reliable performance and consistent results, the CYP2D6 protein provides researchers with the confidence and accuracy required for successful experimentation.
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